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Attitude, knowledge and factors associated with influenza and pneumococcal vaccine uptake in a large cohort of patients with secondary immune deficiency.
Vaccine. 2015 Jul 17; 33(31):3703-8.V

Abstract

BACKGROUND

Immunocompromised patients are at increased risk for severe influenza and invasive pneumococcal diseases. Population-specific vaccine recommendations are thus warranted. This study aimed to estimate the prevalence and predictors of influenza and pneumococcal vaccine uptake in a large cohort of patients with secondary immune deficiency.

METHODS

An anonymous online survey was submitted to the members of 11 French associations of immunocompromised patients. The questionnaire included questions concerning underlying disease, care and treatment, flu and pneumococcal vaccine uptake, attitudes and knowledge about vaccination. Factors associated with vaccine uptake were assessed by multivariate logistic regression.

RESULTS

Among the 10,897 solicited patients, 3653 agreed to participate (33.5%): 75% were female, 20% aged 65+, 79% were followed for an autoimmune disease, 13% were solid organ recipients or waiting for transplantation and 8% were treated for hematological malignancies. 3109 (85%) participants were treated with immunosuppressive therapy. Self-reported vaccine uptake was 59% (95%CI [57-60]) against seasonal influenza and 49% (95%CI [47-50]) against pneumococcal diseases. Better knowledge of and favorable attitudes toward vaccination were positively associated with vaccine uptake while being treated with a biological therapy was negatively associated.

CONCLUSION

Despite specific recommendations regarding immunocompromised patients, influenza and pneumococcal vaccination rates do not reach recommended levels. Targeted information campaigns on vaccination toward these populations should be implemented to improve vaccine coverage and thus reduce the burden of infections.

Authors+Show Affiliations

Inserm, CIC 1417, Paris, France; Assistance Publique-Hôpitaux de Paris (AP-HP), Fédération d'infectiologie, Hôpital Cochin, Paris, France.Inserm, CIC 1417, Paris, France; Assistance Publique-Hôpitaux de Paris (AP-HP), Fédération d'infectiologie, Hôpital Cochin, Paris, France; Université Paris Descartes, Sorbonne Paris Cité, Paris, France; Inserm, F-CRIN, Innovative Clinical Research Network in Vaccinology (I-REIVAC), Paris, France.Assistance Publique-Hôpitaux de Paris (AP-HP), Fédération d'infectiologie, Hôpital Cochin, Paris, France; Université Paris Descartes, Sorbonne Paris Cité, Paris, France.Inserm, CIC 1417, Paris, France; Université Paris Descartes, Sorbonne Paris Cité, Paris, France; Inserm, F-CRIN, Innovative Clinical Research Network in Vaccinology (I-REIVAC), Paris, France.Assistance Publique-Hôpitaux de Paris (AP-HP), Fédération d'infectiologie, Hôpital Cochin, Paris, France.Inserm, F-CRIN, Innovative Clinical Research Network in Vaccinology (I-REIVAC), Paris, France; UMR Inserm 912, SESSTIM-AMU-IRD, Marseille, France; South-eastern Health Regional Observatory (ORS Paca), Marseille, France.Inserm, CIC 1417, Paris, France; Assistance Publique-Hôpitaux de Paris (AP-HP), Fédération d'infectiologie, Hôpital Cochin, Paris, France; Université Paris Descartes, Sorbonne Paris Cité, Paris, France; Inserm, F-CRIN, Innovative Clinical Research Network in Vaccinology (I-REIVAC), Paris, France. Electronic address: odile.launay@cch.aphp.fr.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

26073016

Citation

Loubet, Paul, et al. "Attitude, Knowledge and Factors Associated With Influenza and Pneumococcal Vaccine Uptake in a Large Cohort of Patients With Secondary Immune Deficiency." Vaccine, vol. 33, no. 31, 2015, pp. 3703-8.
Loubet P, Kernéis S, Groh M, et al. Attitude, knowledge and factors associated with influenza and pneumococcal vaccine uptake in a large cohort of patients with secondary immune deficiency. Vaccine. 2015;33(31):3703-8.
Loubet, P., Kernéis, S., Groh, M., Loulergue, P., Blanche, P., Verger, P., & Launay, O. (2015). Attitude, knowledge and factors associated with influenza and pneumococcal vaccine uptake in a large cohort of patients with secondary immune deficiency. Vaccine, 33(31), 3703-8. https://doi.org/10.1016/j.vaccine.2015.06.012
Loubet P, et al. Attitude, Knowledge and Factors Associated With Influenza and Pneumococcal Vaccine Uptake in a Large Cohort of Patients With Secondary Immune Deficiency. Vaccine. 2015 Jul 17;33(31):3703-8. PubMed PMID: 26073016.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Attitude, knowledge and factors associated with influenza and pneumococcal vaccine uptake in a large cohort of patients with secondary immune deficiency. AU - Loubet,Paul, AU - Kernéis,Solen, AU - Groh,Matthieu, AU - Loulergue,Pierre, AU - Blanche,Philippe, AU - Verger,Pierre, AU - Launay,Odile, Y1 - 2015/06/11/ PY - 2015/02/09/received PY - 2015/06/01/revised PY - 2015/06/02/accepted PY - 2015/6/16/entrez PY - 2015/6/16/pubmed PY - 2016/3/25/medline KW - Immunocompromised KW - Influenza KW - Knowledge, Attitudes KW - Pneumococcal KW - Vaccination SP - 3703 EP - 8 JF - Vaccine JO - Vaccine VL - 33 IS - 31 N2 - BACKGROUND: Immunocompromised patients are at increased risk for severe influenza and invasive pneumococcal diseases. Population-specific vaccine recommendations are thus warranted. This study aimed to estimate the prevalence and predictors of influenza and pneumococcal vaccine uptake in a large cohort of patients with secondary immune deficiency. METHODS: An anonymous online survey was submitted to the members of 11 French associations of immunocompromised patients. The questionnaire included questions concerning underlying disease, care and treatment, flu and pneumococcal vaccine uptake, attitudes and knowledge about vaccination. Factors associated with vaccine uptake were assessed by multivariate logistic regression. RESULTS: Among the 10,897 solicited patients, 3653 agreed to participate (33.5%): 75% were female, 20% aged 65+, 79% were followed for an autoimmune disease, 13% were solid organ recipients or waiting for transplantation and 8% were treated for hematological malignancies. 3109 (85%) participants were treated with immunosuppressive therapy. Self-reported vaccine uptake was 59% (95%CI [57-60]) against seasonal influenza and 49% (95%CI [47-50]) against pneumococcal diseases. Better knowledge of and favorable attitudes toward vaccination were positively associated with vaccine uptake while being treated with a biological therapy was negatively associated. CONCLUSION: Despite specific recommendations regarding immunocompromised patients, influenza and pneumococcal vaccination rates do not reach recommended levels. Targeted information campaigns on vaccination toward these populations should be implemented to improve vaccine coverage and thus reduce the burden of infections. SN - 1873-2518 UR - https://www.unboundmedicine.com/medline/citation/26073016/Attitude_knowledge_and_factors_associated_with_influenza_and_pneumococcal_vaccine_uptake_in_a_large_cohort_of_patients_with_secondary_immune_deficiency_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0264-410X(15)00785-9 DB - PRIME DP - Unbound Medicine ER -