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AMPK in Neurodegenerative Diseases: Implications and Therapeutic Perspectives.
Curr Drug Targets. 2016; 17(8):890-907.CD

Abstract

Maintaining proper energy levels in brain neurons is crucial for many cerebral functions such as synaptic transmission, vesicle recycling and axonal transport. AMP-activated protein kinase (AMPK) is the main energy sensor of all living cells. Beside its role as a crucial whole-body energy sensor in hypothalamic neurons, AMPK is also expressed in neurons throughout the brain where it might play additional fundamental roles. For instance, AMPK might be involved in brain development, neuronal polarization and neuronal activity. In addition, recent evidences suggest that AMPK deregulation might participate in neurodegenerative diseases such as Alzheimer's, Parkinson's, Huntington's, amyotrophic lateral sclerosis and ischemic stroke. Therefore, AMPK is emerging as a potential therapeutic target for these neurodegenerative diseases. Here, we will review the recent literature regarding the physiological and pathological role of AMPK in the brain and discuss the resulting potential therapeutic implications.

Authors+Show Affiliations

No affiliation info availableNo affiliation info availableInserm UMR-S 1172, Jean- Pierre Aubert research Centre, Bâtiment Biserte, Place de Verdun, 59045 Lille cedex, France. valerie.vingtdeux@inserm.fr.

Pub Type(s)

Journal Article
Review
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

26073858

Citation

Marinangeli, Claudia, et al. "AMPK in Neurodegenerative Diseases: Implications and Therapeutic Perspectives." Current Drug Targets, vol. 17, no. 8, 2016, pp. 890-907.
Marinangeli C, Didier S, Vingtdeux V. AMPK in Neurodegenerative Diseases: Implications and Therapeutic Perspectives. Curr Drug Targets. 2016;17(8):890-907.
Marinangeli, C., Didier, S., & Vingtdeux, V. (2016). AMPK in Neurodegenerative Diseases: Implications and Therapeutic Perspectives. Current Drug Targets, 17(8), 890-907.
Marinangeli C, Didier S, Vingtdeux V. AMPK in Neurodegenerative Diseases: Implications and Therapeutic Perspectives. Curr Drug Targets. 2016;17(8):890-907. PubMed PMID: 26073858.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - AMPK in Neurodegenerative Diseases: Implications and Therapeutic Perspectives. AU - Marinangeli,Claudia, AU - Didier,Sébastien, AU - Vingtdeux,Valérie, PY - 2014/12/23/received PY - 2015/01/06/revised PY - 2016/01/15/accepted PY - 2015/6/16/entrez PY - 2015/6/16/pubmed PY - 2017/9/7/medline SP - 890 EP - 907 JF - Current drug targets JO - Curr Drug Targets VL - 17 IS - 8 N2 - Maintaining proper energy levels in brain neurons is crucial for many cerebral functions such as synaptic transmission, vesicle recycling and axonal transport. AMP-activated protein kinase (AMPK) is the main energy sensor of all living cells. Beside its role as a crucial whole-body energy sensor in hypothalamic neurons, AMPK is also expressed in neurons throughout the brain where it might play additional fundamental roles. For instance, AMPK might be involved in brain development, neuronal polarization and neuronal activity. In addition, recent evidences suggest that AMPK deregulation might participate in neurodegenerative diseases such as Alzheimer's, Parkinson's, Huntington's, amyotrophic lateral sclerosis and ischemic stroke. Therefore, AMPK is emerging as a potential therapeutic target for these neurodegenerative diseases. Here, we will review the recent literature regarding the physiological and pathological role of AMPK in the brain and discuss the resulting potential therapeutic implications. SN - 1873-5592 UR - https://www.unboundmedicine.com/medline/citation/26073858/AMPK_in_Neurodegenerative_Diseases:_Implications_and_Therapeutic_Perspectives_ L2 - https://www.ingentaconnect.com/openurl?genre=article&issn=1389-4501&volume=17&issue=8&spage=890&aulast=Marinangeli DB - PRIME DP - Unbound Medicine ER -