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Randomized Trial of the Effect of Four Second-Generation Antipsychotics and One First-Generation Antipsychotic on Cigarette Smoking, Alcohol, and Drug Use in Chronic Schizophrenia.
J Nerv Ment Dis. 2015 Jul; 203(7):486-92.JN

Abstract

No large-scale randomized trial has compared the effect of different second-generation antipsychotic drugs and any first-generation drug on alcohol, drug and nicotine use in patients with schizophrenia. The Clinical Antipsychotic Trial of Intervention Effectiveness study randomly assigned 1432 patients formally diagnosed with schizophrenia to four second-generation antipsychotic drugs (olanzapine, risperidone quetiapine, and ziprasidone) and one first-generation antipsychotic (perphenazine) and followed them for up to 18 months. Secondary outcome data documented cigarettes smoked in the past week and alcohol and drug use severity ratings. At baseline, 61% of patients smoked, 35% used alcohol, and 23% used illicit drugs. Although there were significant effects of time showing reduction in substance use over the 18 months (all p < 0.0001), this study found no evidence that any antipsychotic was robustly superior to any other in a secondary analysis of data on substance use outcomes from a large 18-month randomized schizophrenia trial.

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Authors+Show Affiliations

Mohamed S
*New England Mental Illness, Research, Education and Clinical Center, West Haven; †Yale Medical School, New Haven, CT; ‡Duke University, Durham, NC; §Georgia Regents University, Augusta; and ∥Columbia College of Physicians and Surgeons, New York, NY.
Rosenheck RA
No affiliation info available
Lin H
No affiliation info available
Swartz M
No affiliation info available
McEvoy J
No affiliation info available
Stroup S
No affiliation info available

MeSH

AdolescentAdultAgedAlcoholismAntipsychotic AgentsBenzodiazepinesChronic DiseaseComorbidityCross-Sectional StudiesDibenzothiazepinesDouble-Blind MethodFemaleHumansIllicit DrugsMaleMiddle AgedOlanzapinePerphenazinePiperazinesPsychiatric Status Rating ScalesQuetiapine FumarateRisperidoneSchizophreniaSchizophrenic PsychologySmokingSmoking PreventionSubstance-Related DisordersThiazolesYoung Adult

Pub Type(s)

Comparative Study
Journal Article
Randomized Controlled Trial

Language

eng

PubMed ID

26075840

Citation

Mohamed, Somaia, et al. "Randomized Trial of the Effect of Four Second-Generation Antipsychotics and One First-Generation Antipsychotic On Cigarette Smoking, Alcohol, and Drug Use in Chronic Schizophrenia." The Journal of Nervous and Mental Disease, vol. 203, no. 7, 2015, pp. 486-92.
Mohamed S, Rosenheck RA, Lin H, et al. Randomized Trial of the Effect of Four Second-Generation Antipsychotics and One First-Generation Antipsychotic on Cigarette Smoking, Alcohol, and Drug Use in Chronic Schizophrenia. J Nerv Ment Dis. 2015;203(7):486-92.
Mohamed, S., Rosenheck, R. A., Lin, H., Swartz, M., McEvoy, J., & Stroup, S. (2015). Randomized Trial of the Effect of Four Second-Generation Antipsychotics and One First-Generation Antipsychotic on Cigarette Smoking, Alcohol, and Drug Use in Chronic Schizophrenia. The Journal of Nervous and Mental Disease, 203(7), 486-92. https://doi.org/10.1097/NMD.0000000000000317
Mohamed S, et al. Randomized Trial of the Effect of Four Second-Generation Antipsychotics and One First-Generation Antipsychotic On Cigarette Smoking, Alcohol, and Drug Use in Chronic Schizophrenia. J Nerv Ment Dis. 2015;203(7):486-92. PubMed PMID: 26075840.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Randomized Trial of the Effect of Four Second-Generation Antipsychotics and One First-Generation Antipsychotic on Cigarette Smoking, Alcohol, and Drug Use in Chronic Schizophrenia. AU - Mohamed,Somaia, AU - Rosenheck,Robert A, AU - Lin,Haiqun, AU - Swartz,Marvin, AU - McEvoy,Joseph, AU - Stroup,Scott, PY - 2015/6/16/entrez PY - 2015/6/16/pubmed PY - 2015/9/12/medline SP - 486 EP - 92 JF - The Journal of nervous and mental disease JO - J Nerv Ment Dis VL - 203 IS - 7 N2 - No large-scale randomized trial has compared the effect of different second-generation antipsychotic drugs and any first-generation drug on alcohol, drug and nicotine use in patients with schizophrenia. The Clinical Antipsychotic Trial of Intervention Effectiveness study randomly assigned 1432 patients formally diagnosed with schizophrenia to four second-generation antipsychotic drugs (olanzapine, risperidone quetiapine, and ziprasidone) and one first-generation antipsychotic (perphenazine) and followed them for up to 18 months. Secondary outcome data documented cigarettes smoked in the past week and alcohol and drug use severity ratings. At baseline, 61% of patients smoked, 35% used alcohol, and 23% used illicit drugs. Although there were significant effects of time showing reduction in substance use over the 18 months (all p < 0.0001), this study found no evidence that any antipsychotic was robustly superior to any other in a secondary analysis of data on substance use outcomes from a large 18-month randomized schizophrenia trial. SN - 1539-736X UR - https://www.unboundmedicine.com/medline/citation/26075840/Randomized_Trial_of_the_Effect_of_Four_Second_Generation_Antipsychotics_and_One_First_Generation_Antipsychotic_on_Cigarette_Smoking_Alcohol_and_Drug_Use_in_Chronic_Schizophrenia_ L2 - https://doi.org/10.1097/NMD.0000000000000317 DB - PRIME DP - Unbound Medicine ER -