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[T cell receptor delta chain gene rearrangement in acute unclassified leukemia].
Rinsho Ketsueki. 1989 Nov; 30(11):2024-8.RK

Abstract

A 31 year-old male who was treated with radiation under the diagnosis of malignant lymphoma was admitted to our hospital because of systemic erythema and tumor of bilateral upper arms in October, 1987. Leucocyte count of peripheral blood showed 4,400/microliters with 36% leukemic cells and bone marrow was hypercellular with 85.6% leukemic cells. Leukemic cells were negative for peroxidase reaction and lineage specific monoclonal antibodies such as CD3, CD4, CD8, CD10, CD19 and CD20. T cell receptor (TCR) delta gene was rearranged but TCR beta, TCR gamma and immunoglobulin (Ig) genes were in germline configuration. He was treated with combination regimen of doxorubicin, vindesine, prednisolone and L-asparaginase, and complete remission was obtained. These observations suggest that TCR delta gene rearrangement is useful for determination of clonality in cases without rearrangements of the other TCR and Ig genes.

Authors

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Pub Type(s)

Case Reports
English Abstract
Journal Article

Language

jpn

PubMed ID

2607618

Citation

Ito, K, et al. "[T Cell Receptor Delta Chain Gene Rearrangement in Acute Unclassified Leukemia]." [Rinsho Ketsueki] the Japanese Journal of Clinical Hematology, vol. 30, no. 11, 1989, pp. 2024-8.
Ito K, Murakami S, Oku N, et al. [T cell receptor delta chain gene rearrangement in acute unclassified leukemia]. Rinsho Ketsueki. 1989;30(11):2024-8.
Ito, K., Murakami, S., Oku, N., Takeda, N., Fujita, N., Shimazaki, C., Nakanishi, S., Nishio, A., Haruyama, H., & Nakagawa, M. (1989). [T cell receptor delta chain gene rearrangement in acute unclassified leukemia]. [Rinsho Ketsueki] the Japanese Journal of Clinical Hematology, 30(11), 2024-8.
Ito K, et al. [T Cell Receptor Delta Chain Gene Rearrangement in Acute Unclassified Leukemia]. Rinsho Ketsueki. 1989;30(11):2024-8. PubMed PMID: 2607618.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [T cell receptor delta chain gene rearrangement in acute unclassified leukemia]. A1 - Ito,K, AU - Murakami,S, AU - Oku,N, AU - Takeda,N, AU - Fujita,N, AU - Shimazaki,C, AU - Nakanishi,S, AU - Nishio,A, AU - Haruyama,H, AU - Nakagawa,M, PY - 1989/11/1/pubmed PY - 1989/11/1/medline PY - 1989/11/1/entrez SP - 2024 EP - 8 JF - [Rinsho ketsueki] The Japanese journal of clinical hematology JO - Rinsho Ketsueki VL - 30 IS - 11 N2 - A 31 year-old male who was treated with radiation under the diagnosis of malignant lymphoma was admitted to our hospital because of systemic erythema and tumor of bilateral upper arms in October, 1987. Leucocyte count of peripheral blood showed 4,400/microliters with 36% leukemic cells and bone marrow was hypercellular with 85.6% leukemic cells. Leukemic cells were negative for peroxidase reaction and lineage specific monoclonal antibodies such as CD3, CD4, CD8, CD10, CD19 and CD20. T cell receptor (TCR) delta gene was rearranged but TCR beta, TCR gamma and immunoglobulin (Ig) genes were in germline configuration. He was treated with combination regimen of doxorubicin, vindesine, prednisolone and L-asparaginase, and complete remission was obtained. These observations suggest that TCR delta gene rearrangement is useful for determination of clonality in cases without rearrangements of the other TCR and Ig genes. SN - 0485-1439 UR - https://www.unboundmedicine.com/medline/citation/2607618/[T_cell_receptor_delta_chain_gene_rearrangement_in_acute_unclassified_leukemia]_ L2 - https://medlineplus.gov/leukemia.html DB - PRIME DP - Unbound Medicine ER -