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Downregulation of microRNA-382 is associated with poor outcome of esophageal squamous cell carcinoma.
World J Gastroenterol. 2015 Jun 14; 21(22):6884-91.WJ

Abstract

AIM

To study the potential prognostic role of microRNA-382 (miR-382) in esophageal squamous cell carcinoma (ESCC).

METHODS

Forty six patients were divided into 2 groups according to postoperative survival time: the poor outcome group (28 patients), who showed early metastasis but no recurrence, and died within 1 year after surgery, 12 patients of the group received postoperative chemotherapy treatment that was given after early metastasis happening; the good outcome group (18 patients), who had no clinical metastasis and recurrence, and survived 5 years or more after surgery, all patients did not receive any postoperative treatment. Total RNA was extracted from the patients' formalin-fixed and paraffin-embedded esophageal cancer tissues. miR-382 level was evaluated using high-throughput real-time quantitative polymerase chain reaction analysis. The correlation between miR-382 level and clinicopathologic features was analyzed through COX regression model, and Kaplan-Meier analysis was used to analyze the relationship between miR-382 level and patient survival time.

RESULTS

miR-382 was differentially expressed in the two groups. Overall the average miR-382 level in the ESCC patients with good outcome was 9.8 ± 3.8, while miR-382 level in the ESCC patients with poor outcome was 3.0 ± 0.8. The differences of miR-382 levels between two groups were significant (P < 0.05). Kaplan-Meier analysis results showed that miR-382 expression level generally had a significant reverse-correlation with ESCC patient survival time (P < 0.001), in which the patients with higher expressions of miR-382 had a longer survival time either among individuals with the same tumor stage or among the overall patients.

CONCLUSION

miR-382 levels are reverse-correlated with ESCC poor outcomes, suggesting that miR-382 could be a potential predictive biomarker for both prognosis and treatment of ESCC.

Authors+Show Affiliations

Bo Qi, Jian-Guo Lu, Wen-Jian Yao, Xiu-Guang Qin, Shang-Guo Liu, Han-Chen Li, Yu-Zhen Liu, Bao-Sheng Zhao, Department of Thoracic Surgery, The First Affiliated Hospital of Xinxiang Medical University, Weihui 453100, Henan Province, China.Bo Qi, Jian-Guo Lu, Wen-Jian Yao, Xiu-Guang Qin, Shang-Guo Liu, Han-Chen Li, Yu-Zhen Liu, Bao-Sheng Zhao, Department of Thoracic Surgery, The First Affiliated Hospital of Xinxiang Medical University, Weihui 453100, Henan Province, China.Bo Qi, Jian-Guo Lu, Wen-Jian Yao, Xiu-Guang Qin, Shang-Guo Liu, Han-Chen Li, Yu-Zhen Liu, Bao-Sheng Zhao, Department of Thoracic Surgery, The First Affiliated Hospital of Xinxiang Medical University, Weihui 453100, Henan Province, China.Bo Qi, Jian-Guo Lu, Wen-Jian Yao, Xiu-Guang Qin, Shang-Guo Liu, Han-Chen Li, Yu-Zhen Liu, Bao-Sheng Zhao, Department of Thoracic Surgery, The First Affiliated Hospital of Xinxiang Medical University, Weihui 453100, Henan Province, China.Bo Qi, Jian-Guo Lu, Wen-Jian Yao, Xiu-Guang Qin, Shang-Guo Liu, Han-Chen Li, Yu-Zhen Liu, Bao-Sheng Zhao, Department of Thoracic Surgery, The First Affiliated Hospital of Xinxiang Medical University, Weihui 453100, Henan Province, China.Bo Qi, Jian-Guo Lu, Wen-Jian Yao, Xiu-Guang Qin, Shang-Guo Liu, Han-Chen Li, Yu-Zhen Liu, Bao-Sheng Zhao, Department of Thoracic Surgery, The First Affiliated Hospital of Xinxiang Medical University, Weihui 453100, Henan Province, China.Bo Qi, Jian-Guo Lu, Wen-Jian Yao, Xiu-Guang Qin, Shang-Guo Liu, Han-Chen Li, Yu-Zhen Liu, Bao-Sheng Zhao, Department of Thoracic Surgery, The First Affiliated Hospital of Xinxiang Medical University, Weihui 453100, Henan Province, China.Bo Qi, Jian-Guo Lu, Wen-Jian Yao, Xiu-Guang Qin, Shang-Guo Liu, Han-Chen Li, Yu-Zhen Liu, Bao-Sheng Zhao, Department of Thoracic Surgery, The First Affiliated Hospital of Xinxiang Medical University, Weihui 453100, Henan Province, China.Bo Qi, Jian-Guo Lu, Wen-Jian Yao, Xiu-Guang Qin, Shang-Guo Liu, Han-Chen Li, Yu-Zhen Liu, Bao-Sheng Zhao, Department of Thoracic Surgery, The First Affiliated Hospital of Xinxiang Medical University, Weihui 453100, Henan Province, China.Bo Qi, Jian-Guo Lu, Wen-Jian Yao, Xiu-Guang Qin, Shang-Guo Liu, Han-Chen Li, Yu-Zhen Liu, Bao-Sheng Zhao, Department of Thoracic Surgery, The First Affiliated Hospital of Xinxiang Medical University, Weihui 453100, Henan Province, China.Bo Qi, Jian-Guo Lu, Wen-Jian Yao, Xiu-Guang Qin, Shang-Guo Liu, Han-Chen Li, Yu-Zhen Liu, Bao-Sheng Zhao, Department of Thoracic Surgery, The First Affiliated Hospital of Xinxiang Medical University, Weihui 453100, Henan Province, China.

Pub Type(s)

Clinical Study
Journal Article
Research Support, Non-U.S. Gov't
Validation Study

Language

eng

PubMed ID

26078564

Citation

Qi, Bo, et al. "Downregulation of microRNA-382 Is Associated With Poor Outcome of Esophageal Squamous Cell Carcinoma." World Journal of Gastroenterology, vol. 21, no. 22, 2015, pp. 6884-91.
Qi B, Lu JG, Yao WJ, et al. Downregulation of microRNA-382 is associated with poor outcome of esophageal squamous cell carcinoma. World J Gastroenterol. 2015;21(22):6884-91.
Qi, B., Lu, J. G., Yao, W. J., Chang, T. M., Qin, X. G., Ji, Y. H., Wang, T. Y., Liu, S. G., Li, H. C., Liu, Y. Z., & Zhao, B. S. (2015). Downregulation of microRNA-382 is associated with poor outcome of esophageal squamous cell carcinoma. World Journal of Gastroenterology, 21(22), 6884-91. https://doi.org/10.3748/wjg.v21.i22.6884
Qi B, et al. Downregulation of microRNA-382 Is Associated With Poor Outcome of Esophageal Squamous Cell Carcinoma. World J Gastroenterol. 2015 Jun 14;21(22):6884-91. PubMed PMID: 26078564.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Downregulation of microRNA-382 is associated with poor outcome of esophageal squamous cell carcinoma. AU - Qi,Bo, AU - Lu,Jian-Guo, AU - Yao,Wen-Jian, AU - Chang,Ting-Min, AU - Qin,Xiu-Guang, AU - Ji,Ying-Hua, AU - Wang,Tian-Yun, AU - Liu,Shang-Guo, AU - Li,Han-Chen, AU - Liu,Yu-Zhen, AU - Zhao,Bao-Sheng, PY - 2014/12/16/received PY - 2015/02/08/revised PY - 2015/03/30/accepted PY - 2015/6/17/entrez PY - 2015/6/17/pubmed PY - 2016/4/1/medline KW - Esophageal squamous cell carcinoma KW - Metastasis KW - Outcome KW - Prognosis KW - miR-382 SP - 6884 EP - 91 JF - World journal of gastroenterology JO - World J. Gastroenterol. VL - 21 IS - 22 N2 - AIM: To study the potential prognostic role of microRNA-382 (miR-382) in esophageal squamous cell carcinoma (ESCC). METHODS: Forty six patients were divided into 2 groups according to postoperative survival time: the poor outcome group (28 patients), who showed early metastasis but no recurrence, and died within 1 year after surgery, 12 patients of the group received postoperative chemotherapy treatment that was given after early metastasis happening; the good outcome group (18 patients), who had no clinical metastasis and recurrence, and survived 5 years or more after surgery, all patients did not receive any postoperative treatment. Total RNA was extracted from the patients' formalin-fixed and paraffin-embedded esophageal cancer tissues. miR-382 level was evaluated using high-throughput real-time quantitative polymerase chain reaction analysis. The correlation between miR-382 level and clinicopathologic features was analyzed through COX regression model, and Kaplan-Meier analysis was used to analyze the relationship between miR-382 level and patient survival time. RESULTS: miR-382 was differentially expressed in the two groups. Overall the average miR-382 level in the ESCC patients with good outcome was 9.8 ± 3.8, while miR-382 level in the ESCC patients with poor outcome was 3.0 ± 0.8. The differences of miR-382 levels between two groups were significant (P < 0.05). Kaplan-Meier analysis results showed that miR-382 expression level generally had a significant reverse-correlation with ESCC patient survival time (P < 0.001), in which the patients with higher expressions of miR-382 had a longer survival time either among individuals with the same tumor stage or among the overall patients. CONCLUSION: miR-382 levels are reverse-correlated with ESCC poor outcomes, suggesting that miR-382 could be a potential predictive biomarker for both prognosis and treatment of ESCC. SN - 2219-2840 UR - https://www.unboundmedicine.com/medline/citation/26078564/Downregulation_of_microRNA_382_is_associated_with_poor_outcome_of_esophageal_squamous_cell_carcinoma_ L2 - http://www.wjgnet.com/1007-9327/full/v21/i22/6884.htm DB - PRIME DP - Unbound Medicine ER -