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Interaction of Hydrogen Sulfide with Oxygen Sensing under Hypoxia.
Oxid Med Cell Longev. 2015; 2015:758678.OM

Abstract

Based on the discovery of endogenous H2S production, many in depth studies show this gasotransmitter with a variety of physiological and pathological functions. Three enzymes, cystathionine β-synthase (CBS), cystathionine γ-lyase (CSE), and 3-mercaptopyruvate sulfurtransferase (MST), are involved in enzymatic production of H2S. Emerging evidence has elucidated an important protective role of H2S in hypoxic conditions in many mammalian systems. However, the mechanisms by which H2S senses and responses to hypoxia are largely elusive. Hypoxia-inducible factors (HIFs) function as key regulators of oxygen sensing, activating target genes expression under hypoxia. Recent studies have shown that exogenous H2S regulates HIF action in different patterns. The activation of carotid bodies is a sensitive and prompt response to hypoxia, rapidly enhancing general O2 supply. H2S has been identified as an excitatory mediator of hypoxic sensing in the carotid bodies. This paper presents a brief review of the roles of these two pathways which contribute to hypoxic sensing of H2S.

Authors+Show Affiliations

Department of Pathophysiology, Harbin Medical University, Harbin 150086, China.Joint Research Center for Bone and Joint Disease, Model Animal Research Center, Nanjing University, Nanjing 210093, China.Department of Pathophysiology, Harbin Medical University, Harbin 150086, China.Department of Pathophysiology, Harbin Medical University, Harbin 150086, China.Department of Geriatrics, The Second Affiliated Hospital of Harbin Medical University, Harbin 150086, China.Department of Pathophysiology, Harbin Medical University, Harbin 150086, China.Department of Pathophysiology, Harbin Medical University, Harbin 150086, China.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

26078818

Citation

Wu, Bo, et al. "Interaction of Hydrogen Sulfide With Oxygen Sensing Under Hypoxia." Oxidative Medicine and Cellular Longevity, vol. 2015, 2015, p. 758678.
Wu B, Teng H, Zhang L, et al. Interaction of Hydrogen Sulfide with Oxygen Sensing under Hypoxia. Oxid Med Cell Longev. 2015;2015:758678.
Wu, B., Teng, H., Zhang, L., Li, H., Li, J., Wang, L., & Li, H. (2015). Interaction of Hydrogen Sulfide with Oxygen Sensing under Hypoxia. Oxidative Medicine and Cellular Longevity, 2015, 758678. https://doi.org/10.1155/2015/758678
Wu B, et al. Interaction of Hydrogen Sulfide With Oxygen Sensing Under Hypoxia. Oxid Med Cell Longev. 2015;2015:758678. PubMed PMID: 26078818.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Interaction of Hydrogen Sulfide with Oxygen Sensing under Hypoxia. AU - Wu,Bo, AU - Teng,Huajian, AU - Zhang,Li, AU - Li,Hong, AU - Li,Jing, AU - Wang,Lina, AU - Li,Hongzhu, Y1 - 2015/05/11/ PY - 2014/11/30/received PY - 2015/01/22/accepted PY - 2015/6/17/entrez PY - 2015/6/17/pubmed PY - 2016/4/9/medline SP - 758678 EP - 758678 JF - Oxidative medicine and cellular longevity JO - Oxid Med Cell Longev VL - 2015 N2 - Based on the discovery of endogenous H2S production, many in depth studies show this gasotransmitter with a variety of physiological and pathological functions. Three enzymes, cystathionine β-synthase (CBS), cystathionine γ-lyase (CSE), and 3-mercaptopyruvate sulfurtransferase (MST), are involved in enzymatic production of H2S. Emerging evidence has elucidated an important protective role of H2S in hypoxic conditions in many mammalian systems. However, the mechanisms by which H2S senses and responses to hypoxia are largely elusive. Hypoxia-inducible factors (HIFs) function as key regulators of oxygen sensing, activating target genes expression under hypoxia. Recent studies have shown that exogenous H2S regulates HIF action in different patterns. The activation of carotid bodies is a sensitive and prompt response to hypoxia, rapidly enhancing general O2 supply. H2S has been identified as an excitatory mediator of hypoxic sensing in the carotid bodies. This paper presents a brief review of the roles of these two pathways which contribute to hypoxic sensing of H2S. SN - 1942-0994 UR - https://www.unboundmedicine.com/medline/citation/26078818/Interaction_of_Hydrogen_Sulfide_with_Oxygen_Sensing_under_Hypoxia_ L2 - https://doi.org/10.1155/2015/758678 DB - PRIME DP - Unbound Medicine ER -