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Carotenoid consumption is related to lower lipid oxidation and DNA damage in middle-aged men.
Br J Nutr. 2015 Jul; 114(2):257-64.BJ

Abstract

The present cross-sectional study assessed the potential relationships of carotenoid intake with lipid and oxidative stress markers in middle-aged men. A total of 296 apparently healthy middle-aged men (mean age 50.5 (SD 5.0) years, BMI 25.8 (SD 3.5) kg/m(2)) were recruited to participate in the study. Dietary intake, anthropometry, blood pressure, lifestyle features, blood and urine biomarkers were assessed using validated procedures. The lipid markers included NEFA, Castelli index, and TAG:HDL ratio; oxidative stress markers included urinary 8-hydroxy-2'-deoxyguanosine (8-OHdG), 8-iso-PGF2α and plasma oxidised-LDL (ox-LDL). We observed a significant inverse association (P < 0.05) between NEFA concentrations and consumption of lutein plus zeaxanthin, β-carotene, α-carotene and total carotenoid, while Castelli index was negatively associated with daily intake of lycopene, β-carotene and total carotenoids. Regarding oxidative stress biomarkers, urinary 8-OHdG and ox-LDL concentrations were also inversely associated (P < 0.05) with consumption of lycopene, lutein plus zeaxanthin, β-carotene, α-carotene and total carotenoids, regardless of confounding variables. Moreover, there was a negative association of urinary 8-iso-PGF2α concentration with dietary lutein plus zeaxanthin (β - 0.135, 95% CI - 0.268, - 0.001), β-carotene (β - 0.156, 95% CI - 0.277, - 0.034) and with the sum of all carotenoids (β - 0.189, 95% CI - 0.333, - 0.046). In conclusion, total daily carotenoid intake based on five investigated carotenoid types (β-cryptoxanthin, lycopene, lutein plus zeaxanthin, β-carotene and α-carotene) was inversely associated with relevant lipid and oxidative stress markers in middle-aged men, with emphasis on β-carotene that was negatively associated with five of the six lipid and oxidative stress markers evaluated in the present study.

Authors+Show Affiliations

Department of Nutrition and Health,Universidade Federal de Viçosa,Avenue PH Rolfs,Viçosa, Minas Gerais36571-900,Brazil.Department of Physical Education,Universidade Federal de Viçosa,Viçosa, Minas Gerais,Brazil.Department of Nutrition and Health,Universidade Federal de Viçosa,Avenue PH Rolfs,Viçosa, Minas Gerais36571-900,Brazil.Department of Physical Education Science and Health,Universidade Federal de São João del-Rei,São João del-Rei,Minas Gerais,Brazil.Department of General Biology,Universidade Federal de Viçosa,Viçosa, Minas Gerais,Brazil.Department of Nutrition and Health,Universidade Federal de Viçosa,Avenue PH Rolfs,Viçosa, Minas Gerais36571-900,Brazil.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

26079483

Citation

Cocate, P G., et al. "Carotenoid Consumption Is Related to Lower Lipid Oxidation and DNA Damage in Middle-aged Men." The British Journal of Nutrition, vol. 114, no. 2, 2015, pp. 257-64.
Cocate PG, Natali AJ, Alfenas RC, et al. Carotenoid consumption is related to lower lipid oxidation and DNA damage in middle-aged men. Br J Nutr. 2015;114(2):257-64.
Cocate, P. G., Natali, A. J., Alfenas, R. C., de Oliveira, A., dos Santos, E. C., & Hermsdorff, H. H. (2015). Carotenoid consumption is related to lower lipid oxidation and DNA damage in middle-aged men. The British Journal of Nutrition, 114(2), 257-64. https://doi.org/10.1017/S0007114515001622
Cocate PG, et al. Carotenoid Consumption Is Related to Lower Lipid Oxidation and DNA Damage in Middle-aged Men. Br J Nutr. 2015;114(2):257-64. PubMed PMID: 26079483.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Carotenoid consumption is related to lower lipid oxidation and DNA damage in middle-aged men. AU - Cocate,P G, AU - Natali,A J, AU - Alfenas,R C G, AU - de Oliveira,A, AU - dos Santos,E C, AU - Hermsdorff,H H M, Y1 - 2015/06/16/ PY - 2015/6/17/entrez PY - 2015/6/17/pubmed PY - 2015/10/23/medline KW - Carotenoids KW - Food habits KW - Lipids KW - Oxidative stress SP - 257 EP - 64 JF - The British journal of nutrition JO - Br J Nutr VL - 114 IS - 2 N2 - The present cross-sectional study assessed the potential relationships of carotenoid intake with lipid and oxidative stress markers in middle-aged men. A total of 296 apparently healthy middle-aged men (mean age 50.5 (SD 5.0) years, BMI 25.8 (SD 3.5) kg/m(2)) were recruited to participate in the study. Dietary intake, anthropometry, blood pressure, lifestyle features, blood and urine biomarkers were assessed using validated procedures. The lipid markers included NEFA, Castelli index, and TAG:HDL ratio; oxidative stress markers included urinary 8-hydroxy-2'-deoxyguanosine (8-OHdG), 8-iso-PGF2α and plasma oxidised-LDL (ox-LDL). We observed a significant inverse association (P < 0.05) between NEFA concentrations and consumption of lutein plus zeaxanthin, β-carotene, α-carotene and total carotenoid, while Castelli index was negatively associated with daily intake of lycopene, β-carotene and total carotenoids. Regarding oxidative stress biomarkers, urinary 8-OHdG and ox-LDL concentrations were also inversely associated (P < 0.05) with consumption of lycopene, lutein plus zeaxanthin, β-carotene, α-carotene and total carotenoids, regardless of confounding variables. Moreover, there was a negative association of urinary 8-iso-PGF2α concentration with dietary lutein plus zeaxanthin (β - 0.135, 95% CI - 0.268, - 0.001), β-carotene (β - 0.156, 95% CI - 0.277, - 0.034) and with the sum of all carotenoids (β - 0.189, 95% CI - 0.333, - 0.046). In conclusion, total daily carotenoid intake based on five investigated carotenoid types (β-cryptoxanthin, lycopene, lutein plus zeaxanthin, β-carotene and α-carotene) was inversely associated with relevant lipid and oxidative stress markers in middle-aged men, with emphasis on β-carotene that was negatively associated with five of the six lipid and oxidative stress markers evaluated in the present study. SN - 1475-2662 UR - https://www.unboundmedicine.com/medline/citation/26079483/Carotenoid_consumption_is_related_to_lower_lipid_oxidation_and_DNA_damage_in_middle_aged_men_ L2 - https://www.cambridge.org/core/product/identifier/S0007114515001622/type/journal_article DB - PRIME DP - Unbound Medicine ER -