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Antinociceptive and anti-inflammatory effects of the aerial parts of Artemisia dracunculus in mice.
Pharm Biol. 2016; 54(3):549-54.PB

Abstract

CONTEXT

Tarragon (Artemisia dracunculus L., Asteraceae) is an ancient herb, which is widely used as a medicine, flavoring, or fragrance.

OBJECTIVE

To determine the antinociceptive and anti-inflammatory effects of aerial parts of tarragon, we investigated the effects of ethanolic extract of the plant in adult male Balb/c mice.

MATERIALS AND METHODS

Antinociceptive activity was determined using formalin, hot-plate, and writhing tests. The effect of the ethanolic extract on acute inflammation was evaluated by xylene-induced ear edema in mice. The ethanolic extract was administered at doses of 5, 10, 50, and 100 mg/kg, i.p. The control group received saline as vehicle of ethanolic extract.

RESULTS

Our results showed that the ethanolic extract (50 and 100 mg/kg) decreased both phases of pain in the formalin test (ED50 = 109.66 and 87.13 mg/kg, respectively). In the hot-plate test, the extract (50 and 100 mg/kg) increased pain threshold during 60 min (ED50 = 81.03 mg/kg). The extract (50 and 100 mg/kg) exhibited antinociceptive activity against acetic acid-induced writhing (ED50 = 66.99 mg/kg). The extract (50 and 100 mg/kg) showed significant activity in the xylene ear edema test (ED50 = 78.20 mg/kg). Pretreatment of the animals with naloxone decreased the analgesia induced by the extract in hot-plate and formalin tests; therefore, opioid receptors may be involved, at least partly, in the analgesic effect of tarragon extract.

DISCUSSION AND CONCLUSION

The results suggested that tarragon have significant analgesic and anti-inflammatory effects in mice, and, therefore, further studies are required to evaluate these effects and additional potential of the plant.

Authors+Show Affiliations

a Department of Biology, Science and Research Branch , Islamic Azad University , Tehran , Iran .b Biological Science Faculty, Kharazmi University , Tehran , Iran , and.c Neurophysiology Research Center, Shahid Beheshti University of Medical Sciences , Tehran , Iran.a Department of Biology, Science and Research Branch , Islamic Azad University , Tehran , Iran .

Pub Type(s)

Journal Article

Language

eng

PubMed ID

26079854

Citation

Eidi, Akram, et al. "Antinociceptive and Anti-inflammatory Effects of the Aerial Parts of Artemisia Dracunculus in Mice." Pharmaceutical Biology, vol. 54, no. 3, 2016, pp. 549-54.
Eidi A, Oryan S, Zaringhalam J, et al. Antinociceptive and anti-inflammatory effects of the aerial parts of Artemisia dracunculus in mice. Pharm Biol. 2016;54(3):549-54.
Eidi, A., Oryan, S., Zaringhalam, J., & Rad, M. (2016). Antinociceptive and anti-inflammatory effects of the aerial parts of Artemisia dracunculus in mice. Pharmaceutical Biology, 54(3), 549-54. https://doi.org/10.3109/13880209.2015.1056312
Eidi A, et al. Antinociceptive and Anti-inflammatory Effects of the Aerial Parts of Artemisia Dracunculus in Mice. Pharm Biol. 2016;54(3):549-54. PubMed PMID: 26079854.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Antinociceptive and anti-inflammatory effects of the aerial parts of Artemisia dracunculus in mice. AU - Eidi,Akram, AU - Oryan,Shahrbanoo, AU - Zaringhalam,Jalal, AU - Rad,Mitra, Y1 - 2015/06/16/ PY - 2015/6/17/entrez PY - 2015/6/17/pubmed PY - 2016/10/25/medline KW - Analgesia KW - inflammation KW - tarragon SP - 549 EP - 54 JF - Pharmaceutical biology JO - Pharm Biol VL - 54 IS - 3 N2 - CONTEXT: Tarragon (Artemisia dracunculus L., Asteraceae) is an ancient herb, which is widely used as a medicine, flavoring, or fragrance. OBJECTIVE: To determine the antinociceptive and anti-inflammatory effects of aerial parts of tarragon, we investigated the effects of ethanolic extract of the plant in adult male Balb/c mice. MATERIALS AND METHODS: Antinociceptive activity was determined using formalin, hot-plate, and writhing tests. The effect of the ethanolic extract on acute inflammation was evaluated by xylene-induced ear edema in mice. The ethanolic extract was administered at doses of 5, 10, 50, and 100 mg/kg, i.p. The control group received saline as vehicle of ethanolic extract. RESULTS: Our results showed that the ethanolic extract (50 and 100 mg/kg) decreased both phases of pain in the formalin test (ED50 = 109.66 and 87.13 mg/kg, respectively). In the hot-plate test, the extract (50 and 100 mg/kg) increased pain threshold during 60 min (ED50 = 81.03 mg/kg). The extract (50 and 100 mg/kg) exhibited antinociceptive activity against acetic acid-induced writhing (ED50 = 66.99 mg/kg). The extract (50 and 100 mg/kg) showed significant activity in the xylene ear edema test (ED50 = 78.20 mg/kg). Pretreatment of the animals with naloxone decreased the analgesia induced by the extract in hot-plate and formalin tests; therefore, opioid receptors may be involved, at least partly, in the analgesic effect of tarragon extract. DISCUSSION AND CONCLUSION: The results suggested that tarragon have significant analgesic and anti-inflammatory effects in mice, and, therefore, further studies are required to evaluate these effects and additional potential of the plant. SN - 1744-5116 UR - https://www.unboundmedicine.com/medline/citation/26079854/Antinociceptive_and_anti_inflammatory_effects_of_the_aerial_parts_of_Artemisia_dracunculus_in_mice_ L2 - http://www.tandfonline.com/doi/full/10.3109/13880209.2015.1056312 DB - PRIME DP - Unbound Medicine ER -