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Incorporation of eicosapentaenioic and docosahexaenoic acids into breast adipose tissue of women at high risk of breast cancer: a randomized clinical trial of dietary fish and n-3 fatty acid capsules.
Mol Nutr Food Res. 2015 Sep; 59(9):1780-90.MN

Abstract

SCOPE

The fatty acid profile of dietary lipids is reflected in mammary adipose tissue and may influence mammary gland biology and cancer risk. To determine the effects of fish consumption on breast adipose tissue fatty acids, we conducted a study of fish versus n-3 PUFA supplements in women at increased risk of breast cancer.

METHODS AND RESULTS

High risk women were randomized to comparable doses of marine n-3 PUFAs as canned salmon + albacore or capsules for 3 months. Pre- and posttreatment fatty acid profiles were obtained by GC. Dietary fish (n = 12) and n-3 PUFA capsules (n = 13) yielded increased eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) in plasma (p < 0.0001), erythrocyte membranes (p < 0.0001), and breast fat (p < 0.01) at 3 months. Women taking capsules had higher plasma and erythrocyte membrane EPA changes (∼four versus twofold, p = 0.002), without significant differences in DHA. Increases in breast adipose EPA, DHA were similar for both groups. Higher BMI correlated with smaller changes in plasma, erythrocyte membrane EPA, and breast adipose EPA, DHA. Adherence was excellent at 93.9% overall and higher in the fish arm (p = 0.01).

CONCLUSION

Fish provides an excellent source of n-3 PUFAs that increases breast adipose EPA, DHA similar to supplements and represents a well-tolerated intervention for future studies of the impact of n-3 PUFAs and dietary patterns on breast cancer.

Authors+Show Affiliations

Division of Surgical Oncology, Department of Surgery, The Ohio State University, Columbus, Ohio, USA.College of Nursing, The Ohio State University, Columbus, Ohio, USA.Human Sciences, The Ohio State University, Columbus, Ohio, USA.Division of Biostatistics, College of Public Health, The Ohio State University, Columbus, Ohio, USA.Human Sciences, The Ohio State University, Columbus, Ohio, USA.Human Sciences, The Ohio State University, Columbus, Ohio, USA.Division of Medical Oncology, Department of Internal Medicine, The Ohio State University, Columbus, Ohio, USA. Comprehensive Cancer Center, The Ohio State University, Columbus, Ohio, USA.Human Sciences, The Ohio State University, Columbus, Ohio, USA. Comprehensive Cancer Center, The Ohio State University, Columbus, Ohio, USA.Division of Surgical Oncology, Department of Surgery, The Ohio State University, Columbus, Ohio, USA. Comprehensive Cancer Center, The Ohio State University, Columbus, Ohio, USA.

Pub Type(s)

Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

26081224

Citation

Straka, Shana, et al. "Incorporation of Eicosapentaenioic and Docosahexaenoic Acids Into Breast Adipose Tissue of Women at High Risk of Breast Cancer: a Randomized Clinical Trial of Dietary Fish and N-3 Fatty Acid Capsules." Molecular Nutrition & Food Research, vol. 59, no. 9, 2015, pp. 1780-90.
Straka S, Lester JL, Cole RM, et al. Incorporation of eicosapentaenioic and docosahexaenoic acids into breast adipose tissue of women at high risk of breast cancer: a randomized clinical trial of dietary fish and n-3 fatty acid capsules. Mol Nutr Food Res. 2015;59(9):1780-90.
Straka, S., Lester, J. L., Cole, R. M., Andridge, R. R., Puchala, S., Rose, A. M., Clinton, S. K., Belury, M. A., & Yee, L. D. (2015). Incorporation of eicosapentaenioic and docosahexaenoic acids into breast adipose tissue of women at high risk of breast cancer: a randomized clinical trial of dietary fish and n-3 fatty acid capsules. Molecular Nutrition & Food Research, 59(9), 1780-90. https://doi.org/10.1002/mnfr.201500161
Straka S, et al. Incorporation of Eicosapentaenioic and Docosahexaenoic Acids Into Breast Adipose Tissue of Women at High Risk of Breast Cancer: a Randomized Clinical Trial of Dietary Fish and N-3 Fatty Acid Capsules. Mol Nutr Food Res. 2015;59(9):1780-90. PubMed PMID: 26081224.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Incorporation of eicosapentaenioic and docosahexaenoic acids into breast adipose tissue of women at high risk of breast cancer: a randomized clinical trial of dietary fish and n-3 fatty acid capsules. AU - Straka,Shana, AU - Lester,Joanne L, AU - Cole,Rachel M, AU - Andridge,Rebecca R, AU - Puchala,Sarah, AU - Rose,Angela M, AU - Clinton,Steven K, AU - Belury,Martha A, AU - Yee,Lisa D, Y1 - 2015/07/07/ PY - 2015/02/28/received PY - 2015/06/01/revised PY - 2015/06/07/accepted PY - 2015/6/18/entrez PY - 2015/6/18/pubmed PY - 2016/7/29/medline KW - Breast adipose tissue KW - DHA KW - Dietary fish KW - EPA KW - n-3 PUFAs SP - 1780 EP - 90 JF - Molecular nutrition & food research JO - Mol Nutr Food Res VL - 59 IS - 9 N2 - SCOPE: The fatty acid profile of dietary lipids is reflected in mammary adipose tissue and may influence mammary gland biology and cancer risk. To determine the effects of fish consumption on breast adipose tissue fatty acids, we conducted a study of fish versus n-3 PUFA supplements in women at increased risk of breast cancer. METHODS AND RESULTS: High risk women were randomized to comparable doses of marine n-3 PUFAs as canned salmon + albacore or capsules for 3 months. Pre- and posttreatment fatty acid profiles were obtained by GC. Dietary fish (n = 12) and n-3 PUFA capsules (n = 13) yielded increased eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) in plasma (p < 0.0001), erythrocyte membranes (p < 0.0001), and breast fat (p < 0.01) at 3 months. Women taking capsules had higher plasma and erythrocyte membrane EPA changes (∼four versus twofold, p = 0.002), without significant differences in DHA. Increases in breast adipose EPA, DHA were similar for both groups. Higher BMI correlated with smaller changes in plasma, erythrocyte membrane EPA, and breast adipose EPA, DHA. Adherence was excellent at 93.9% overall and higher in the fish arm (p = 0.01). CONCLUSION: Fish provides an excellent source of n-3 PUFAs that increases breast adipose EPA, DHA similar to supplements and represents a well-tolerated intervention for future studies of the impact of n-3 PUFAs and dietary patterns on breast cancer. SN - 1613-4133 UR - https://www.unboundmedicine.com/medline/citation/26081224/Incorporation_of_eicosapentaenioic_and_docosahexaenoic_acids_into_breast_adipose_tissue_of_women_at_high_risk_of_breast_cancer:_a_randomized_clinical_trial_of_dietary_fish_and_n_3_fatty_acid_capsules_ L2 - https://doi.org/10.1002/mnfr.201500161 DB - PRIME DP - Unbound Medicine ER -