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Dietary fat, fat subtypes and hepatocellular carcinoma in a large European cohort.
Int J Cancer 2015; 137(11):2715-28IJ

Abstract

The role of amount and type of dietary fat consumption in the etiology of hepatocellular carcinoma (HCC) is poorly understood, despite suggestive biological plausibility. The associations of total fat, fat subtypes and fat sources with HCC incidence were investigated in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort, which includes 191 incident HCC cases diagnosed between 1992 and 2010. Diet was assessed by country-specific, validated dietary questionnaires. A single 24-hr diet recall from a cohort subsample was used for measurement error calibration. Hazard ratios (HR) and 95% confidence intervals (95% CI) were estimated from Cox proportional hazard models. Hepatitis B and C viruses (HBV/HCV) status and biomarkers of liver function were assessed separately in a nested case-control subset with available blood samples (HCC = 122). In multivariable calibrated models, there was a statistically significant inverse association between total fat intake and risk of HCC (per 10 g/day, HR = 0.80, 95% CI: 0.65-0.99), which was mainly driven by monounsaturated fats (per 5 g/day, HR = 0.71, 95% CI: 0.55-0.92) rather than polyunsaturated fats (per 5 g/day, HR = 0.92, 95% CI: 0.68-1.25). There was no association between saturated fats (HR = 1.08, 95% CI: 0.88-1.34) and HCC risk. The ratio of polyunsaturated/monounsaturated fats to saturated fats was not significantly associated with HCC risk (per 0.2 point, HR = 0.86, 95% CI: 0.73-1.01). Restriction of analyses to HBV/HCV free participants or adjustment for liver function did not substantially alter the findings. In this large prospective European cohort, higher consumption of monounsaturated fats is associated with lower HCC risk.

Authors+Show Affiliations

International Agency for Research on Cancer (IARC-WHO), Lyon, France.Department of Epidemiology, Rollins School of Public Health, , Winship Cancer Institute, Emory University, Atlanta, GA.International Agency for Research on Cancer (IARC-WHO), Lyon, France.Department of Epidemiology, German Institute of Human Nutrition Potsdam-Rehbruecke, Nuthetal, Germany.Department of Hygiene, Epidemiology and Medical Statistics, University of Athens Medical School, Athens, Greece.Department of Hygiene, Epidemiology and Medical Statistics, University of Athens Medical School, Athens, Greece. Department of Epidemiology, Harvard School of Public Health, Boston, MA. Bureau of Epidemiologic Research, Academy of Athens, Athens, Greece.Department of Public Health, Aarhus University, Aarhus, Denmark.Danish Cancer Society Research Center, Copenhagen, Denmark.Department of Public Health, Aarhus University, Aarhus, Denmark.Danish Cancer Society Research Center, Copenhagen, Denmark.Inserm, Centre for Research in Epidemiology and Population Health, U1018, Gustave Roussy Institute, F-94805, Villejuif, France. Institut Gustave-Roussy (IGR), Paris South University, UMRS 1018, F-94805, Villejuif, France.Inserm, Centre for Research in Epidemiology and Population Health, U1018, Gustave Roussy Institute, F-94805, Villejuif, France. Institut Gustave-Roussy (IGR), Paris South University, UMRS 1018, F-94805, Villejuif, France.Inserm, Centre for Research in Epidemiology and Population Health, U1018, Gustave Roussy Institute, F-94805, Villejuif, France. Institut Gustave-Roussy (IGR), Paris South University, UMRS 1018, F-94805, Villejuif, France.Department of Epidemiology, German Institute of Human Nutrition Potsdam-Rehbruecke, Nuthetal, Germany.Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany.Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany.Bureau of Epidemiologic Research, Academy of Athens, Athens, Greece. Hellenic Health Foundation, Athens, Greece.Department of Hygiene, Epidemiology and Medical Statistics, University of Athens Medical School, Athens, Greece. Hellenic Health Foundation, Athens, Greece.Hellenic Health Foundation, Athens, Greece.Molecular and Nutritional Epidemiology Unit, Cancer Research and Prevention Institute-ISPO, Florence, Italy.Dipartimento Di Medicina Clinica E Chirurgia, Federico II University, Naples, Italy.Epidemiology and Prevention Unit, Department of Preventive & Predictive Medicine, Fondazione IRCCS Istituto Nazionale Dei Tumori, Milan, Italy.Unit of Cancer Epidemiology, Department of Medical Sciences, University of Turin and Città Della Salute E Della Scienza Hospital-CPO Piedmont, Turin, Italy. Department of Epidemiology, Local Health Unit To3, Turin, Italy.Cancer Registy and Histopathology Unit, "Civic - M.P. Arezzo" Hospital, ASP, Ragusa, Italy.Department for Determinants of Chronic Diseases (DCD), National Institute for Public Health and the Environment (RIVM), Bilthoven, The Netherlands. Department of Gastroenterology and Hepatology, University Medical Centre, Utrecht, The Netherlands. Department of Epidemiology and Biostatistics, the School of Public Health, Imperial College London, London, United Kingdom. Department of Social & Preventive Medicine, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia.Department of Epidemiology and Biostatistics, the School of Public Health, Imperial College London, London, United Kingdom. Department of Epidemiology, Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, The Netherlands.Department of Nutrition, Institute of Basic Medical Sciences, University of Oslo, Oslo, Norway.Department of Community Medicine, Faculty of Health Sciences, University of Tromsø, the Arctic University of Norway, Tromsø, Norway.Department of Community Medicine, Faculty of Health Sciences, University of Tromsø, the Arctic University of Norway, Tromsø, Norway. Cancer Registry of Norway, Oslo, Norway. Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden. Group of Genetic Epidemiology, Folkhälsan Research Center, Helsinki, Finland.Navarre Public Health Institute, Pamplona, Spain. CIBER Epidemiology and Public Health CIBERESP, Madrid, Spain.Unit of Nutrition and Cancer, Cancer Epidemiology Research Program, Institut Català D'oncologia, L'hospitalet De Llobregat, Spain.CIBER Epidemiology and Public Health CIBERESP, Madrid, Spain. Department of Epidemiology, Murcia Regional Health Authority, IMIB-Arrixaca, Murcia, Spain.Public Health Direction and Biodonostia Research Institute and CIBERESP, Basque Regional Health Department, San Sebastian, Spain.Public Health Directorate, Asturias, Spain.Department of Odontology, Umeå University, Umeå, Sweden.Department of Clinical Sciences, Division of Internal Medicine, Lund University, Sweden.Department of Clinical Sciences, Division of Internal Medicine, Lund University, Sweden. Department of Gastroenterology and Nutrition, Skåne University Hospital, Malmö, Sweden.Department of Public Health and Clinical Medicine, Nutritional Research, Umeå University, Umeå, Sweden.School of Clinical Medicine, Clinical Gerontology Unit, University of Cambridge, Cambridge, United Kingdom.Cancer Epidemiology Unit, Nuffield Department of Population Health, University of Oxford, Oxford, United Kingdom.MRC Epidemiology Unit, Cambridge, United Kingdom.International Agency for Research on Cancer (IARC-WHO), Lyon, France.International Agency for Research on Cancer (IARC-WHO), Lyon, France.International Agency for Research on Cancer (IARC-WHO), Lyon, France.Department of Epidemiology and Biostatistics, School of Public Health, Faculty of Medicine, Imperial College, London, United Kingdom.Department of Epidemiology and Biostatistics, School of Public Health, Faculty of Medicine, Imperial College, London, United Kingdom.Department of Epidemiology and Biostatistics, School of Public Health, Faculty of Medicine, Imperial College, London, United Kingdom.International Agency for Research on Cancer (IARC-WHO), Lyon, France.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

26081477

Citation

Duarte-Salles, Talita, et al. "Dietary Fat, Fat Subtypes and Hepatocellular Carcinoma in a Large European Cohort." International Journal of Cancer, vol. 137, no. 11, 2015, pp. 2715-28.
Duarte-Salles T, Fedirko V, Stepien M, et al. Dietary fat, fat subtypes and hepatocellular carcinoma in a large European cohort. Int J Cancer. 2015;137(11):2715-28.
Duarte-Salles, T., Fedirko, V., Stepien, M., Aleksandrova, K., Bamia, C., Lagiou, P., ... Jenab, M. (2015). Dietary fat, fat subtypes and hepatocellular carcinoma in a large European cohort. International Journal of Cancer, 137(11), pp. 2715-28. doi:10.1002/ijc.29643.
Duarte-Salles T, et al. Dietary Fat, Fat Subtypes and Hepatocellular Carcinoma in a Large European Cohort. Int J Cancer. 2015 Dec 1;137(11):2715-28. PubMed PMID: 26081477.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Dietary fat, fat subtypes and hepatocellular carcinoma in a large European cohort. AU - Duarte-Salles,Talita, AU - Fedirko,Veronika, AU - Stepien,Magdalena, AU - Aleksandrova,Krasimira, AU - Bamia,Christina, AU - Lagiou,Pagona, AU - Laursen,Anne Sofie Dam, AU - Hansen,Louise, AU - Overvad,Kim, AU - Tjønneland,Anne, AU - Boutron-Ruault,Marie-Christine, AU - Fagherazzi,Guy, AU - His,Mathilde, AU - Boeing,Heiner, AU - Katzke,Verena, AU - Kühn,Tilman, AU - Trichopoulou,Antonia, AU - Valanou,Elissavet, AU - Kritikou,Maria, AU - Masala,Giovanna, AU - Panico,Salvatore, AU - Sieri,Sabina, AU - Ricceri,Fulvio, AU - Tumino,Rosario, AU - Bueno-de-Mesquita,H B As, AU - Peeters,Petra H, AU - Hjartåker,Anette, AU - Skeie,Guri, AU - Weiderpass,Elisabete, AU - Ardanaz,Eva, AU - Bonet,Catalina, AU - Chirlaque,Maria-Dolores, AU - Dorronsoro,Miren, AU - Quirós,J Ramón, AU - Johansson,Ingegerd, AU - Ohlsson,Bodil, AU - Sjöberg,Klas, AU - Wennberg,Maria, AU - Khaw,Kay-Tee, AU - Travis,Ruth C, AU - Wareham,Nick, AU - Ferrari,Pietro, AU - Freisling,Heinz, AU - Romieu,Isabelle, AU - Cross,Amanda J, AU - Gunter,Marc, AU - Lu,Yunxia, AU - Jenab,Mazda, Y1 - 2015/07/06/ PY - 2015/03/05/received PY - 2015/05/21/accepted PY - 2015/6/18/entrez PY - 2015/6/18/pubmed PY - 2015/12/15/medline KW - European populations KW - cohort study KW - dietary fats KW - hepatocellular carcinoma SP - 2715 EP - 28 JF - International journal of cancer JO - Int. J. Cancer VL - 137 IS - 11 N2 - The role of amount and type of dietary fat consumption in the etiology of hepatocellular carcinoma (HCC) is poorly understood, despite suggestive biological plausibility. The associations of total fat, fat subtypes and fat sources with HCC incidence were investigated in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort, which includes 191 incident HCC cases diagnosed between 1992 and 2010. Diet was assessed by country-specific, validated dietary questionnaires. A single 24-hr diet recall from a cohort subsample was used for measurement error calibration. Hazard ratios (HR) and 95% confidence intervals (95% CI) were estimated from Cox proportional hazard models. Hepatitis B and C viruses (HBV/HCV) status and biomarkers of liver function were assessed separately in a nested case-control subset with available blood samples (HCC = 122). In multivariable calibrated models, there was a statistically significant inverse association between total fat intake and risk of HCC (per 10 g/day, HR = 0.80, 95% CI: 0.65-0.99), which was mainly driven by monounsaturated fats (per 5 g/day, HR = 0.71, 95% CI: 0.55-0.92) rather than polyunsaturated fats (per 5 g/day, HR = 0.92, 95% CI: 0.68-1.25). There was no association between saturated fats (HR = 1.08, 95% CI: 0.88-1.34) and HCC risk. The ratio of polyunsaturated/monounsaturated fats to saturated fats was not significantly associated with HCC risk (per 0.2 point, HR = 0.86, 95% CI: 0.73-1.01). Restriction of analyses to HBV/HCV free participants or adjustment for liver function did not substantially alter the findings. In this large prospective European cohort, higher consumption of monounsaturated fats is associated with lower HCC risk. SN - 1097-0215 UR - https://www.unboundmedicine.com/medline/citation/26081477/Dietary_fat_fat_subtypes_and_hepatocellular_carcinoma_in_a_large_European_cohort_ L2 - https://doi.org/10.1002/ijc.29643 DB - PRIME DP - Unbound Medicine ER -