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Hippocampal structure, metabolism, and inflammatory response after a 6-week intense aerobic exercise in healthy young adults: a controlled trial.
J Cereb Blood Flow Metab. 2015 Oct; 35(10):1570-8.JC

Abstract

Interventional studies suggest that changes in physical fitness affect brain function and structure. We studied the influence of high intensity physical exercise on hippocampal volume and metabolism in 17 young healthy male adults during a 6-week exercise program compared with matched controls. We further aimed to relate these changes to hypothesized changes in exercised-induced brain-derived neurotrophic factor (BDNF), interleukin-6 (IL-6), and tumor necrosis factor alpha (TNF-α). We show profound improvement of physical fitness in most subjects and a positive correlation between the degree of fitness improvement and increased BDNF levels. We unexpectedly observed an average volume decrease of about 2%, which was restricted to right hippocampal subfields CA2/3, subiculum, and dentate gyrus and which correlated with fitness improvement and increased BDNF levels negatively. This result indicates that mainly those subjects who did not benefit from the exercise program show decreased hippocampal volume, reduced BDNF levels, and increased TNF-α concentrations. While spectroscopy results do not indicate any neuronal loss (unchanged N-acetylaspartate levels) decreased glutamate-glutamine levels were observed in the right anterior hippocampus in the exercise group only. Responder characteristics need to be studied in more detail. Our results point to an important role of the inflammatory response after exercise on changes in hippocampal structure.

Authors+Show Affiliations

Psychiatric Brain and Body Research Group Jena, Department of Psychiatry and Psychotherapy, Jena University Hospital, Jena, Germany.Department of Sports Medicine and Health Promotion, Friedrich-Schiller-University, Jena, Germany.Psychiatric Brain and Body Research Group Jena, Department of Psychiatry and Psychotherapy, Jena University Hospital, Jena, Germany.Psychiatric Brain and Body Research Group Jena, Department of Psychiatry and Psychotherapy, Jena University Hospital, Jena, Germany.Psychiatric Brain and Body Research Group Jena, Department of Psychiatry and Psychotherapy, Jena University Hospital, Jena, Germany.Psychiatric Brain and Body Research Group Jena, Department of Psychiatry and Psychotherapy, Jena University Hospital, Jena, Germany.Medical Physics Group, Department of Diagnostic and Interventional Radiology, Jena University Hospital-Friedrich Schiller University, Jena, Germany.Department of Sports Medicine and Health Promotion, Friedrich-Schiller-University, Jena, Germany.Department of Psychiatry and Psychotherapy, University Hospital, Jena, Germany.Department of Sports Medicine and Health Promotion, Friedrich-Schiller-University, Jena, Germany.Medical Physics Group, Department of Diagnostic and Interventional Radiology, Jena University Hospital-Friedrich Schiller University, Jena, Germany.Psychiatric Brain and Body Research Group Jena, Department of Psychiatry and Psychotherapy, Jena University Hospital, Jena, Germany.

Pub Type(s)

Clinical Trial
Journal Article

Language

eng

PubMed ID

26082010

Citation

Wagner, Gerd, et al. "Hippocampal Structure, Metabolism, and Inflammatory Response After a 6-week Intense Aerobic Exercise in Healthy Young Adults: a Controlled Trial." Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism, vol. 35, no. 10, 2015, pp. 1570-8.
Wagner G, Herbsleb M, de la Cruz F, et al. Hippocampal structure, metabolism, and inflammatory response after a 6-week intense aerobic exercise in healthy young adults: a controlled trial. J Cereb Blood Flow Metab. 2015;35(10):1570-8.
Wagner, G., Herbsleb, M., de la Cruz, F., Schumann, A., Brünner, F., Schachtzabel, C., Gussew, A., Puta, C., Smesny, S., Gabriel, H. W., Reichenbach, J. R., & Bär, K. J. (2015). Hippocampal structure, metabolism, and inflammatory response after a 6-week intense aerobic exercise in healthy young adults: a controlled trial. Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism, 35(10), 1570-8. https://doi.org/10.1038/jcbfm.2015.125
Wagner G, et al. Hippocampal Structure, Metabolism, and Inflammatory Response After a 6-week Intense Aerobic Exercise in Healthy Young Adults: a Controlled Trial. J Cereb Blood Flow Metab. 2015;35(10):1570-8. PubMed PMID: 26082010.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Hippocampal structure, metabolism, and inflammatory response after a 6-week intense aerobic exercise in healthy young adults: a controlled trial. AU - Wagner,Gerd, AU - Herbsleb,Marco, AU - de la Cruz,Feliberto, AU - Schumann,Andy, AU - Brünner,Franziska, AU - Schachtzabel,Claudia, AU - Gussew,Alexander, AU - Puta,Christian, AU - Smesny,Stefan, AU - Gabriel,Holger W, AU - Reichenbach,Jürgen R, AU - Bär,Karl-Jürgen, Y1 - 2015/06/17/ PY - 2015/02/05/received PY - 2015/05/02/revised PY - 2015/05/12/accepted PY - 2015/6/18/entrez PY - 2015/6/18/pubmed PY - 2015/12/31/medline SP - 1570 EP - 8 JF - Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism JO - J. Cereb. Blood Flow Metab. VL - 35 IS - 10 N2 - Interventional studies suggest that changes in physical fitness affect brain function and structure. We studied the influence of high intensity physical exercise on hippocampal volume and metabolism in 17 young healthy male adults during a 6-week exercise program compared with matched controls. We further aimed to relate these changes to hypothesized changes in exercised-induced brain-derived neurotrophic factor (BDNF), interleukin-6 (IL-6), and tumor necrosis factor alpha (TNF-α). We show profound improvement of physical fitness in most subjects and a positive correlation between the degree of fitness improvement and increased BDNF levels. We unexpectedly observed an average volume decrease of about 2%, which was restricted to right hippocampal subfields CA2/3, subiculum, and dentate gyrus and which correlated with fitness improvement and increased BDNF levels negatively. This result indicates that mainly those subjects who did not benefit from the exercise program show decreased hippocampal volume, reduced BDNF levels, and increased TNF-α concentrations. While spectroscopy results do not indicate any neuronal loss (unchanged N-acetylaspartate levels) decreased glutamate-glutamine levels were observed in the right anterior hippocampus in the exercise group only. Responder characteristics need to be studied in more detail. Our results point to an important role of the inflammatory response after exercise on changes in hippocampal structure. SN - 1559-7016 UR - https://www.unboundmedicine.com/medline/citation/26082010/Hippocampal_structure_metabolism_and_inflammatory_response_after_a_6_week_intense_aerobic_exercise_in_healthy_young_adults:_a_controlled_trial_ L2 - http://journals.sagepub.com/doi/full/10.1038/jcbfm.2015.125?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -