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Global cognitive performance and frailty in non-demented community-dwelling older adults: Findings from the Sasaguri Genkimon Study.
Geriatr Gerontol Int. 2016 Jun; 16(6):729-36.GG

Abstract

AIM

To investigate the associations of global cognitive performance with frailty and pre-frailty in non-demented community-dwelling older adults.

METHOD

A cross-sectional study was carried out using data from the baseline survey of the Sasaguri Genkimon Study in 2011. The study sample consisted of 1565 older adults with complete data and no evidence of dementia. Global cognitive performance was evaluated using the Montreal Cognitive Assessment (MoCA) and the Mini-Mental State Examination (MMSE). Frailty state was defined using the Cardiovascular Health Study criteria, based on five components: unintentional weight loss, low grip strength, exhaustion, low gait speed and low physical activity.

RESULTS

Total MoCA and MMSE scores, and their domain-specific scores decreased across the non-frail, pre-frail and frail groups. Poorer total MoCA and MMSE scores, as well as their domain-specific scores, were associated with the greater likelihood of being frail, but not with pre-frailty after full adjustment. The strength of the association with frailty was greater for total MoCA score than for total MMSE score. Domain-specific scores for visuospatial abilities and attention domains in both of the MoCA and MMSE were consistently associated with the likelihood of pre-frailty and frailty, even after being mutually adjusted for all domains.

CONCLUSIONS

The MoCA performance is more strongly associated with the odds of frailty than the MMSE performance in the relatively functional and non-demented older adult population. The present findings could contribute to further exploration of possible common pathways that can be targeted in the prevention and management for both of these two conditions. Geriatr Gerontol Int 2015; ●●: ●●-●●.

Authors+Show Affiliations

Department of Behavior and Health Sciences, Graduate School of Human-Environment Studies, Kyushu University, Fukuoka, Japan.Department of Behavior and Health Sciences, Graduate School of Human-Environment Studies, Kyushu University, Fukuoka, Japan.Central Research Institute for Physical Activity, Fukuoka University, Fukuoka, Japan.Department of Behavior and Health Sciences, Graduate School of Human-Environment Studies, Kyushu University, Fukuoka, Japan.Tokyo Metropolitan Institute of Gerontology, Tokyo, Japan.Department of Behavior and Health Sciences, Graduate School of Human-Environment Studies, Kyushu University, Fukuoka, Japan. Faculty of Arts and Science, Kyushu University, Fukuoka, Japan.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

26082148

Citation

Chen, Sanmei, et al. "Global Cognitive Performance and Frailty in Non-demented Community-dwelling Older Adults: Findings From the Sasaguri Genkimon Study." Geriatrics & Gerontology International, vol. 16, no. 6, 2016, pp. 729-36.
Chen S, Honda T, Narazaki K, et al. Global cognitive performance and frailty in non-demented community-dwelling older adults: Findings from the Sasaguri Genkimon Study. Geriatr Gerontol Int. 2016;16(6):729-36.
Chen, S., Honda, T., Narazaki, K., Chen, T., Nofuji, Y., & Kumagai, S. (2016). Global cognitive performance and frailty in non-demented community-dwelling older adults: Findings from the Sasaguri Genkimon Study. Geriatrics & Gerontology International, 16(6), 729-36. https://doi.org/10.1111/ggi.12546
Chen S, et al. Global Cognitive Performance and Frailty in Non-demented Community-dwelling Older Adults: Findings From the Sasaguri Genkimon Study. Geriatr Gerontol Int. 2016;16(6):729-36. PubMed PMID: 26082148.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Global cognitive performance and frailty in non-demented community-dwelling older adults: Findings from the Sasaguri Genkimon Study. AU - Chen,Sanmei, AU - Honda,Takanori, AU - Narazaki,Kenji, AU - Chen,Tao, AU - Nofuji,Yu, AU - Kumagai,Shuzo, Y1 - 2015/06/16/ PY - 2015/05/07/accepted PY - 2015/6/18/entrez PY - 2015/6/18/pubmed PY - 2017/6/27/medline KW - aging KW - cognition KW - community health KW - frailty KW - pre-frailty SP - 729 EP - 36 JF - Geriatrics & gerontology international JO - Geriatr Gerontol Int VL - 16 IS - 6 N2 - AIM: To investigate the associations of global cognitive performance with frailty and pre-frailty in non-demented community-dwelling older adults. METHOD: A cross-sectional study was carried out using data from the baseline survey of the Sasaguri Genkimon Study in 2011. The study sample consisted of 1565 older adults with complete data and no evidence of dementia. Global cognitive performance was evaluated using the Montreal Cognitive Assessment (MoCA) and the Mini-Mental State Examination (MMSE). Frailty state was defined using the Cardiovascular Health Study criteria, based on five components: unintentional weight loss, low grip strength, exhaustion, low gait speed and low physical activity. RESULTS: Total MoCA and MMSE scores, and their domain-specific scores decreased across the non-frail, pre-frail and frail groups. Poorer total MoCA and MMSE scores, as well as their domain-specific scores, were associated with the greater likelihood of being frail, but not with pre-frailty after full adjustment. The strength of the association with frailty was greater for total MoCA score than for total MMSE score. Domain-specific scores for visuospatial abilities and attention domains in both of the MoCA and MMSE were consistently associated with the likelihood of pre-frailty and frailty, even after being mutually adjusted for all domains. CONCLUSIONS: The MoCA performance is more strongly associated with the odds of frailty than the MMSE performance in the relatively functional and non-demented older adult population. The present findings could contribute to further exploration of possible common pathways that can be targeted in the prevention and management for both of these two conditions. Geriatr Gerontol Int 2015; ●●: ●●-●●. SN - 1447-0594 UR - https://www.unboundmedicine.com/medline/citation/26082148/Global_cognitive_performance_and_frailty_in_non_demented_community_dwelling_older_adults:_Findings_from_the_Sasaguri_Genkimon_Study_ L2 - https://doi.org/10.1111/ggi.12546 DB - PRIME DP - Unbound Medicine ER -