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Associations between Vitamin D Status, Supplementation, Outdoor Work and Risk of Parkinson's Disease: A Meta-Analysis Assessment.
Nutrients 2015; 7(6):4817-27N

Abstract

The present study aimed to quantitatively assess the associations between vitamin D and Parkinson's Disease (PD) risks, which include: (i) risk of PD in subjects with deficient and insufficient vitamin D levels; (ii) association between vitamin D supplementation and risk of PD; and (iii) association between outdoor work and PD risk, through meta-analyzing available data. An electronic literature search supplemented by hand searching up to March 2015 identified seven eligible studies comprising 5690 PD patients and 21251 matched controls. Odds ratio (OR) and 95% confidence interval (CI) of PD risk were assessed through pooling the collected data from eligible studies using Stata software. Pooled data showed that subjects with deficient and insufficient vitamin D levels had increased PD risks compared with matched-controls according to the corresponding OR: 2.08, 95% CI: 1.63 to 2.65, and 1.29, 95% CI: 1.10 to 1.51. Vitamin D supplementation was associated with significantly reduced risk of PD (OR: 0.62, 95% CI: 0.35 to 0.90). Outdoor work was also related to reduced risk of PD (OR: 0.72, 95% CI: 0.63 to 0.81). The findings may stimulate larger, well-designed studies to further verify the associations between vitamin D and PD risk.

Authors+Show Affiliations

Shandong Provincial Research Center for Bioinformatic Engineering and Technique, School of Life Sciences, Shandong University of Technology, Zibo 255049, China. shen@sdut.edu.cn.Shandong Provincial Research Center for Bioinformatic Engineering and Technique, School of Life Sciences, Shandong University of Technology, Zibo 255049, China. jhf@sdut.edu.cn.

Pub Type(s)

Journal Article
Meta-Analysis
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

26083115

Citation

Shen, Liang, and Hong-Fang Ji. "Associations Between Vitamin D Status, Supplementation, Outdoor Work and Risk of Parkinson's Disease: a Meta-Analysis Assessment." Nutrients, vol. 7, no. 6, 2015, pp. 4817-27.
Shen L, Ji HF. Associations between Vitamin D Status, Supplementation, Outdoor Work and Risk of Parkinson's Disease: A Meta-Analysis Assessment. Nutrients. 2015;7(6):4817-27.
Shen, L., & Ji, H. F. (2015). Associations between Vitamin D Status, Supplementation, Outdoor Work and Risk of Parkinson's Disease: A Meta-Analysis Assessment. Nutrients, 7(6), pp. 4817-27. doi:10.3390/nu7064817.
Shen L, Ji HF. Associations Between Vitamin D Status, Supplementation, Outdoor Work and Risk of Parkinson's Disease: a Meta-Analysis Assessment. Nutrients. 2015 Jun 15;7(6):4817-27. PubMed PMID: 26083115.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Associations between Vitamin D Status, Supplementation, Outdoor Work and Risk of Parkinson's Disease: A Meta-Analysis Assessment. AU - Shen,Liang, AU - Ji,Hong-Fang, Y1 - 2015/06/15/ PY - 2015/04/24/received PY - 2015/05/25/revised PY - 2015/06/08/accepted PY - 2015/6/18/entrez PY - 2015/6/18/pubmed PY - 2016/5/4/medline KW - Parkinson’s disease KW - meta-analysis KW - outdoor work KW - vitamin D SP - 4817 EP - 27 JF - Nutrients JO - Nutrients VL - 7 IS - 6 N2 - The present study aimed to quantitatively assess the associations between vitamin D and Parkinson's Disease (PD) risks, which include: (i) risk of PD in subjects with deficient and insufficient vitamin D levels; (ii) association between vitamin D supplementation and risk of PD; and (iii) association between outdoor work and PD risk, through meta-analyzing available data. An electronic literature search supplemented by hand searching up to March 2015 identified seven eligible studies comprising 5690 PD patients and 21251 matched controls. Odds ratio (OR) and 95% confidence interval (CI) of PD risk were assessed through pooling the collected data from eligible studies using Stata software. Pooled data showed that subjects with deficient and insufficient vitamin D levels had increased PD risks compared with matched-controls according to the corresponding OR: 2.08, 95% CI: 1.63 to 2.65, and 1.29, 95% CI: 1.10 to 1.51. Vitamin D supplementation was associated with significantly reduced risk of PD (OR: 0.62, 95% CI: 0.35 to 0.90). Outdoor work was also related to reduced risk of PD (OR: 0.72, 95% CI: 0.63 to 0.81). The findings may stimulate larger, well-designed studies to further verify the associations between vitamin D and PD risk. SN - 2072-6643 UR - https://www.unboundmedicine.com/medline/citation/26083115/full_citation L2 - http://www.mdpi.com/resolver?pii=nu7064817 DB - PRIME DP - Unbound Medicine ER -