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MIND diet slows cognitive decline with aging.
Alzheimers Dement. 2015 Sep; 11(9):1015-22.AD

Abstract

INTRODUCTION

The Mediterranean and dash diets have been shown to slow cognitive decline; however, neither diet is specific to the nutrition literature on dementia prevention.

METHODS

We devised the Mediterranean-Dietary Approach to Systolic Hypertension (DASH) diet intervention for neurodegenerative delay (MIND) diet score that specifically captures dietary components shown to be neuroprotective and related it to change in cognition over an average 4.7 years among 960 participants of the Memory and Aging Project.

RESULTS

In adjusted mixed models, the MIND score was positively associated with slower decline in global cognitive score (β = 0.0092; P < .0001) and with each of five cognitive domains. The difference in decline rates for being in the top tertile of MIND diet scores versus the lowest was equivalent to being 7.5 years younger in age.

DISCUSSION

The study findings suggest that the MIND diet substantially slows cognitive decline with age. Replication of these findings in a dietary intervention trial would be required to verify its relevance to brain health.

Authors+Show Affiliations

Department of Internal Medicine at Rush University Medical Center, Chicago, IL, USA. Electronic address: martha_c_morris@rush.edu.Department of Clinical Nutrition at Rush University Medical Center, Chicago, IL, USA.Department of Internal Medicine at Rush University Medical Center, Chicago, IL, USA.Department of Nutrition, Harvard School of Public Health, Harvard University, Boston, MA, USA.Department of Behavioral Sciences at Rush University Medical Center, Chicago, IL, USA; Department of Neurological Sciences at Rush University Medical Center, Chicago, IL, USA; Rush Alzheimer's Disease Center at Rush University Medical Center, Chicago, IL, USA.Department of Neurological Sciences at Rush University Medical Center, Chicago, IL, USA; Rush Alzheimer's Disease Center at Rush University Medical Center, Chicago, IL, USA.Department of Neurological Sciences at Rush University Medical Center, Chicago, IL, USA; Rush Alzheimer's Disease Center at Rush University Medical Center, Chicago, IL, USA.

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural

Language

eng

PubMed ID

26086182

Citation

Morris, Martha Clare, et al. "MIND Diet Slows Cognitive Decline With Aging." Alzheimer's & Dementia : the Journal of the Alzheimer's Association, vol. 11, no. 9, 2015, pp. 1015-22.
Morris MC, Tangney CC, Wang Y, et al. MIND diet slows cognitive decline with aging. Alzheimers Dement. 2015;11(9):1015-22.
Morris, M. C., Tangney, C. C., Wang, Y., Sacks, F. M., Barnes, L. L., Bennett, D. A., & Aggarwal, N. T. (2015). MIND diet slows cognitive decline with aging. Alzheimer's & Dementia : the Journal of the Alzheimer's Association, 11(9), 1015-22. https://doi.org/10.1016/j.jalz.2015.04.011
Morris MC, et al. MIND Diet Slows Cognitive Decline With Aging. Alzheimers Dement. 2015;11(9):1015-22. PubMed PMID: 26086182.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - MIND diet slows cognitive decline with aging. AU - Morris,Martha Clare, AU - Tangney,Christy C, AU - Wang,Yamin, AU - Sacks,Frank M, AU - Barnes,Lisa L, AU - Bennett,David A, AU - Aggarwal,Neelum T, Y1 - 2015/06/15/ PY - 2014/10/29/received PY - 2015/03/02/revised PY - 2015/04/09/accepted PY - 2015/6/19/entrez PY - 2015/6/19/pubmed PY - 2016/6/22/medline KW - Aging KW - Cognition KW - Cognitive decline KW - Diet KW - Epidemiologic study KW - Nutrition SP - 1015 EP - 22 JF - Alzheimer's & dementia : the journal of the Alzheimer's Association JO - Alzheimers Dement VL - 11 IS - 9 N2 - INTRODUCTION: The Mediterranean and dash diets have been shown to slow cognitive decline; however, neither diet is specific to the nutrition literature on dementia prevention. METHODS: We devised the Mediterranean-Dietary Approach to Systolic Hypertension (DASH) diet intervention for neurodegenerative delay (MIND) diet score that specifically captures dietary components shown to be neuroprotective and related it to change in cognition over an average 4.7 years among 960 participants of the Memory and Aging Project. RESULTS: In adjusted mixed models, the MIND score was positively associated with slower decline in global cognitive score (β = 0.0092; P < .0001) and with each of five cognitive domains. The difference in decline rates for being in the top tertile of MIND diet scores versus the lowest was equivalent to being 7.5 years younger in age. DISCUSSION: The study findings suggest that the MIND diet substantially slows cognitive decline with age. Replication of these findings in a dietary intervention trial would be required to verify its relevance to brain health. SN - 1552-5279 UR - https://www.unboundmedicine.com/medline/citation/26086182/MIND_diet_slows_cognitive_decline_with_aging_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1552-5260(15)00194-6 DB - PRIME DP - Unbound Medicine ER -