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Long-term exposure to fine particulate matter and incidence of type 2 diabetes mellitus in a cohort study: effects of total and traffic-specific air pollution.
Environ Health. 2015 Jun 19; 14:53.EH

Abstract

BACKGROUND

Studies investigating the link between long-term exposure to air pollution and incidence of diabetes are still scarce and results are inconsistent, possibly due to different compositions of the particle mixture. We investigate the long-term effect of traffic-specific and total particulate matter (PM) and road proximity on cumulative incidence of diabetes mellitus (mainly type 2) in a large German cohort.

METHODS

We followed prospectively 3607 individuals without diabetes at baseline (2000-2003) from the Heinz Nixdorf Recall Study in Germany (mean follow-up time 5.1 years). Mean annual exposures to total as well as traffic-specific PM10 and PM2.5 at residence were estimated using a chemistry transport model (EURAD, 1 km(2) resolution). Effect estimates for an increase of 1 μg/m(3) in PM were obtained with Poisson regression adjusting for sex, age, body mass index, lifestyle factors, area-level and individual-level socio-economic status, and city.

RESULTS

331 incident cases developed. Adjusted RRs for total PM10 and PM2.5 were 1.05 (95%-CI: 1.00;1.10) and 1.03 (95%-CI: 0.95;1.12), respectively. Markedly higher point estimates were found for local traffic-specific PM with RRs of 1.36 (95%-CI: 0.98;1.89) for PM10 and 1.36 (95%-CI: 0.97;1.89) for PM2.5. Individuals living closer than 100 m to a busy road had a more than 30% higher risk (1.37;95%-CI: 1.04;1.81) than those living further than 200 m away.

CONCLUSIONS

Long-term exposure to total PM increases type two diabetes risk in the general population, as does living close to a major road. Local traffic-specific PM was related to higher risks for type two diabetes than total PM.

Authors+Show Affiliations

IUF - Leibniz Research Institute for Environmental Medicine, Düsseldorf, Germany. gudrun.weinmayr@uni-duesseldorf.de. Medical School, Heinrich Heine University of Düsseldorf, Düsseldorf, Germany. gudrun.weinmayr@uni-duesseldorf.de.IUF - Leibniz Research Institute for Environmental Medicine, Düsseldorf, Germany. frauke.hennig@iuf-duesseldorf.de.IUF - Leibniz Research Institute for Environmental Medicine, Düsseldorf, Germany. kateryna.fuks@iuf-duesseldorf.de.Institute for Medical Informatics, Biometry and Epidemiology, University Hospital of Essen, University of Duisburg-Essen, Essen, Germany. Michael.Nonnemacher@uk-essen.de.Rhenish Institute for Environmental Research at the University of Cologne, Cologne, Germany. Hermann.Jakobs@eurad.uni-koeln.de.Department of Cardiology, West German Heart Centre of Essen, University of Duisburg-Essen, Essen, Germany. Stefan.Moehlenkamp@uk-essen.de.Department of Cardiology, West German Heart Centre of Essen, University of Duisburg-Essen, Essen, Germany. Raimund.Erbel@uk-essen.de.Institute for Medical Informatics, Biometry and Epidemiology, University Hospital of Essen, University of Duisburg-Essen, Essen, Germany. k-h.Joeckel@uk-essen.de.IUF - Leibniz Research Institute for Environmental Medicine, Düsseldorf, Germany. b.hoffmann@uni-duesseldorf.de. Medical School, Heinrich Heine University of Düsseldorf, Düsseldorf, Germany. b.hoffmann@uni-duesseldorf.de.Institute for Medical Informatics, Biometry and Epidemiology, University Hospital of Essen, University of Duisburg-Essen, Essen, Germany. Susanne.Moebus@uk-essen.de.No affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

26087770

Citation

Weinmayr, Gudrun, et al. "Long-term Exposure to Fine Particulate Matter and Incidence of Type 2 Diabetes Mellitus in a Cohort Study: Effects of Total and Traffic-specific Air Pollution." Environmental Health : a Global Access Science Source, vol. 14, 2015, p. 53.
Weinmayr G, Hennig F, Fuks K, et al. Long-term exposure to fine particulate matter and incidence of type 2 diabetes mellitus in a cohort study: effects of total and traffic-specific air pollution. Environ Health. 2015;14:53.
Weinmayr, G., Hennig, F., Fuks, K., Nonnemacher, M., Jakobs, H., Möhlenkamp, S., Erbel, R., Jöckel, K. H., Hoffmann, B., & Moebus, S. (2015). Long-term exposure to fine particulate matter and incidence of type 2 diabetes mellitus in a cohort study: effects of total and traffic-specific air pollution. Environmental Health : a Global Access Science Source, 14, 53. https://doi.org/10.1186/s12940-015-0031-x
Weinmayr G, et al. Long-term Exposure to Fine Particulate Matter and Incidence of Type 2 Diabetes Mellitus in a Cohort Study: Effects of Total and Traffic-specific Air Pollution. Environ Health. 2015 Jun 19;14:53. PubMed PMID: 26087770.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Long-term exposure to fine particulate matter and incidence of type 2 diabetes mellitus in a cohort study: effects of total and traffic-specific air pollution. AU - Weinmayr,Gudrun, AU - Hennig,Frauke, AU - Fuks,Kateryna, AU - Nonnemacher,Michael, AU - Jakobs,Hermann, AU - Möhlenkamp,Stefan, AU - Erbel,Raimund, AU - Jöckel,Karl-Heinz, AU - Hoffmann,Barbara, AU - Moebus,Susanne, AU - ,, Y1 - 2015/06/19/ PY - 2014/11/25/received PY - 2015/05/14/accepted PY - 2015/6/20/entrez PY - 2015/6/20/pubmed PY - 2016/4/5/medline SP - 53 EP - 53 JF - Environmental health : a global access science source JO - Environ Health VL - 14 N2 - BACKGROUND: Studies investigating the link between long-term exposure to air pollution and incidence of diabetes are still scarce and results are inconsistent, possibly due to different compositions of the particle mixture. We investigate the long-term effect of traffic-specific and total particulate matter (PM) and road proximity on cumulative incidence of diabetes mellitus (mainly type 2) in a large German cohort. METHODS: We followed prospectively 3607 individuals without diabetes at baseline (2000-2003) from the Heinz Nixdorf Recall Study in Germany (mean follow-up time 5.1 years). Mean annual exposures to total as well as traffic-specific PM10 and PM2.5 at residence were estimated using a chemistry transport model (EURAD, 1 km(2) resolution). Effect estimates for an increase of 1 μg/m(3) in PM were obtained with Poisson regression adjusting for sex, age, body mass index, lifestyle factors, area-level and individual-level socio-economic status, and city. RESULTS: 331 incident cases developed. Adjusted RRs for total PM10 and PM2.5 were 1.05 (95%-CI: 1.00;1.10) and 1.03 (95%-CI: 0.95;1.12), respectively. Markedly higher point estimates were found for local traffic-specific PM with RRs of 1.36 (95%-CI: 0.98;1.89) for PM10 and 1.36 (95%-CI: 0.97;1.89) for PM2.5. Individuals living closer than 100 m to a busy road had a more than 30% higher risk (1.37;95%-CI: 1.04;1.81) than those living further than 200 m away. CONCLUSIONS: Long-term exposure to total PM increases type two diabetes risk in the general population, as does living close to a major road. Local traffic-specific PM was related to higher risks for type two diabetes than total PM. SN - 1476-069X UR - https://www.unboundmedicine.com/medline/citation/26087770/Long_term_exposure_to_fine_particulate_matter_and_incidence_of_type_2_diabetes_mellitus_in_a_cohort_study:_effects_of_total_and_traffic_specific_air_pollution_ L2 - https://ehjournal.biomedcentral.com/articles/10.1186/s12940-015-0031-x DB - PRIME DP - Unbound Medicine ER -