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Enantioselective Hydroformylation of 1-Alkenes with Commercial Ph-BPE Ligand.
Org Lett. 2015 Jul 02; 17(13):3264-7.OL

Abstract

A rhodium complex, in conjunction with commercially available Ph-BPE ligand, catalyzes the branch-selective asymmetric hydroformylation of 1-alkenes and rapidly generates α-chiral aldehydes. A wide range of terminal olefins including 1-dodecene were examined, and all delivered high enantioselectivity (up to 98:2 er) as well as good branch:linear ratios (up to 15:1).

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Authors+Show Affiliations

Yu Z
Department of Chemistry, Merkert Chemistry Center, Boston College, Chestnut Hill, Massachusetts 02467, United States.
Eno MS
Department of Chemistry, Merkert Chemistry Center, Boston College, Chestnut Hill, Massachusetts 02467, United States.
Annis AH
Department of Chemistry, Merkert Chemistry Center, Boston College, Chestnut Hill, Massachusetts 02467, United States.
Morken JP
Department of Chemistry, Merkert Chemistry Center, Boston College, Chestnut Hill, Massachusetts 02467, United States.

MeSH

AldehydesAlkenesCatalysisCombinatorial Chemistry TechniquesLigandsMolecular StructureRhodiumStereoisomerism

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

26091063

Citation

Yu, Zhiyong, et al. "Enantioselective Hydroformylation of 1-Alkenes With Commercial Ph-BPE Ligand." Organic Letters, vol. 17, no. 13, 2015, pp. 3264-7.
Yu Z, Eno MS, Annis AH, et al. Enantioselective Hydroformylation of 1-Alkenes with Commercial Ph-BPE Ligand. Org Lett. 2015;17(13):3264-7.
Yu, Z., Eno, M. S., Annis, A. H., & Morken, J. P. (2015). Enantioselective Hydroformylation of 1-Alkenes with Commercial Ph-BPE Ligand. Organic Letters, 17(13), 3264-7. https://doi.org/10.1021/acs.orglett.5b01421
Yu Z, et al. Enantioselective Hydroformylation of 1-Alkenes With Commercial Ph-BPE Ligand. Org Lett. 2015 Jul 2;17(13):3264-7. PubMed PMID: 26091063.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Enantioselective Hydroformylation of 1-Alkenes with Commercial Ph-BPE Ligand. AU - Yu,Zhiyong, AU - Eno,Meredith S, AU - Annis,Alexandra H, AU - Morken,James P, Y1 - 2015/06/19/ PY - 2015/6/20/entrez PY - 2015/6/20/pubmed PY - 2015/11/11/medline SP - 3264 EP - 7 JF - Organic letters JO - Org Lett VL - 17 IS - 13 N2 - A rhodium complex, in conjunction with commercially available Ph-BPE ligand, catalyzes the branch-selective asymmetric hydroformylation of 1-alkenes and rapidly generates α-chiral aldehydes. A wide range of terminal olefins including 1-dodecene were examined, and all delivered high enantioselectivity (up to 98:2 er) as well as good branch:linear ratios (up to 15:1). SN - 1523-7052 UR - https://www.unboundmedicine.com/medline/citation/26091063/Enantioselective_Hydroformylation_of_1_Alkenes_with_Commercial_Ph_BPE_Ligand_ DB - PRIME DP - Unbound Medicine ER -