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High frequencies of vitamin B12 and folic acid deficiencies and gastric parietal cell antibody positivity in oral submucous fibrosis patients.
J Formos Med Assoc. 2015 Sep; 114(9):813-9.JF

Abstract

BACKGROUND/PURPOSE

Oral submucous fibrosis (OSF) is a chronic progressive scaring oral disease associated with areca quid chewing. This study evaluated whether OSF patients had anemia, hematinic deficiencies, and serum gastric parietal cell antibody (GPCA) positivity.

METHODS

The blood hemoglobin (Hb), iron, vitamin B12, and folic acid concentrations, mean corpuscular volume, and serum GPCA in 68 male OSF patients were measured and compared with the corresponding data in 136 age-matched male healthy control individuals.

RESULTS

We found that five (7.4%), 14 (20.6%), 34 (50.0%), 28 (41.2%), and nine (13.2%) of the 68 male OSF patients had Hb (< 13 g/dL), iron (≤ 70 μg/dL), vitamin B12 (≤ 450 pg/mL), and folic acid (≤ 6 ng/mL) deficiencies, and serum GPCA positivity, respectively. Furthermore, OSF patients had a significantly higher frequency of Hb (p = 0.006), vitamin B12 (p < 0.001), or folic acid (p < 0.001) deficiency and of serum GPCA positivity (p = 0.011) than healthy control participants. Of the five OSF patients with anemia, two had thalassemia trait, one had iron deficiency anemia, and two had macrocytic anemia (mean corpuscular volume ≥ 100 fL). In addition, of the nine OSF patients with serum GPCA positivity, six had vitamin B12 deficiency, five had folic acid deficiency, and two had iron deficiency. However, none of the nine GPCA-positive OSF patients had pernicious anemia based on the strict World Health Organization definition.

CONCLUSION

We conclude that there are high frequencies of vitamin B12 and folic acid deficiencies and of serum GPCA positivity in our male OSF patients.

Authors+Show Affiliations

Graduate Institute of Clinical Dentistry, School of Dentistry, National Taiwan University, Taipei, Taiwan; Department of Dentistry, National Taiwan University Hospital, College of Medicine, National Taiwan University, Taipei, Taiwan.Graduate Institute of Clinical Dentistry, School of Dentistry, National Taiwan University, Taipei, Taiwan; Department of Dentistry, National Taiwan University Hospital, College of Medicine, National Taiwan University, Taipei, Taiwan.Graduate Institute of Clinical Dentistry, School of Dentistry, National Taiwan University, Taipei, Taiwan; Department of Dentistry, National Taiwan University Hospital, College of Medicine, National Taiwan University, Taipei, Taiwan.Graduate Institute of Clinical Dentistry, School of Dentistry, National Taiwan University, Taipei, Taiwan; Department of Dentistry, National Taiwan University Hospital, College of Medicine, National Taiwan University, Taipei, Taiwan; Graduate Institute of Oral Biology, School of Dentistry, National Taiwan University, Taipei, Taiwan.Graduate Institute of Clinical Dentistry, School of Dentistry, National Taiwan University, Taipei, Taiwan; Department of Dentistry, National Taiwan University Hospital, College of Medicine, National Taiwan University, Taipei, Taiwan.Graduate Institute of Clinical Dentistry, School of Dentistry, National Taiwan University, Taipei, Taiwan; Department of Dentistry, National Taiwan University Hospital, College of Medicine, National Taiwan University, Taipei, Taiwan. Electronic address: jyfchang@ntu.edu.tw.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

26094182

Citation

Wang, Yi-Ping, et al. "High Frequencies of Vitamin B12 and Folic Acid Deficiencies and Gastric Parietal Cell Antibody Positivity in Oral Submucous Fibrosis Patients." Journal of the Formosan Medical Association = Taiwan Yi Zhi, vol. 114, no. 9, 2015, pp. 813-9.
Wang YP, Wu YC, Cheng SJ, et al. High frequencies of vitamin B12 and folic acid deficiencies and gastric parietal cell antibody positivity in oral submucous fibrosis patients. J Formos Med Assoc. 2015;114(9):813-9.
Wang, Y. P., Wu, Y. C., Cheng, S. J., Chen, H. M., Sun, A., & Chang, J. Y. (2015). High frequencies of vitamin B12 and folic acid deficiencies and gastric parietal cell antibody positivity in oral submucous fibrosis patients. Journal of the Formosan Medical Association = Taiwan Yi Zhi, 114(9), 813-9. https://doi.org/10.1016/j.jfma.2015.05.011
Wang YP, et al. High Frequencies of Vitamin B12 and Folic Acid Deficiencies and Gastric Parietal Cell Antibody Positivity in Oral Submucous Fibrosis Patients. J Formos Med Assoc. 2015;114(9):813-9. PubMed PMID: 26094182.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - High frequencies of vitamin B12 and folic acid deficiencies and gastric parietal cell antibody positivity in oral submucous fibrosis patients. AU - Wang,Yi-Ping, AU - Wu,Yang-Che, AU - Cheng,Shih-Jung, AU - Chen,Hsin-Ming, AU - Sun,Andy, AU - Chang,Julia Yu-Fong, Y1 - 2015/06/17/ PY - 2015/03/15/received PY - 2015/03/26/revised PY - 2015/05/08/accepted PY - 2015/6/22/entrez PY - 2015/6/22/pubmed PY - 2016/11/15/medline KW - anemia KW - folic acid deficiency KW - gastric parietal cell antibody KW - hemoglobin KW - oral submucous fibrosis KW - vitamin B(12) deficiency SP - 813 EP - 9 JF - Journal of the Formosan Medical Association = Taiwan yi zhi JO - J Formos Med Assoc VL - 114 IS - 9 N2 - BACKGROUND/PURPOSE: Oral submucous fibrosis (OSF) is a chronic progressive scaring oral disease associated with areca quid chewing. This study evaluated whether OSF patients had anemia, hematinic deficiencies, and serum gastric parietal cell antibody (GPCA) positivity. METHODS: The blood hemoglobin (Hb), iron, vitamin B12, and folic acid concentrations, mean corpuscular volume, and serum GPCA in 68 male OSF patients were measured and compared with the corresponding data in 136 age-matched male healthy control individuals. RESULTS: We found that five (7.4%), 14 (20.6%), 34 (50.0%), 28 (41.2%), and nine (13.2%) of the 68 male OSF patients had Hb (< 13 g/dL), iron (≤ 70 μg/dL), vitamin B12 (≤ 450 pg/mL), and folic acid (≤ 6 ng/mL) deficiencies, and serum GPCA positivity, respectively. Furthermore, OSF patients had a significantly higher frequency of Hb (p = 0.006), vitamin B12 (p < 0.001), or folic acid (p < 0.001) deficiency and of serum GPCA positivity (p = 0.011) than healthy control participants. Of the five OSF patients with anemia, two had thalassemia trait, one had iron deficiency anemia, and two had macrocytic anemia (mean corpuscular volume ≥ 100 fL). In addition, of the nine OSF patients with serum GPCA positivity, six had vitamin B12 deficiency, five had folic acid deficiency, and two had iron deficiency. However, none of the nine GPCA-positive OSF patients had pernicious anemia based on the strict World Health Organization definition. CONCLUSION: We conclude that there are high frequencies of vitamin B12 and folic acid deficiencies and of serum GPCA positivity in our male OSF patients. SN - 0929-6646 UR - https://www.unboundmedicine.com/medline/citation/26094182/High_frequencies_of_vitamin_B12_and_folic_acid_deficiencies_and_gastric_parietal_cell_antibody_positivity_in_oral_submucous_fibrosis_patients_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0929-6646(15)00181-3 DB - PRIME DP - Unbound Medicine ER -