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Position paper of the EAACI: food allergy due to immunological cross-reactions with common inhalant allergens.
Allergy 2015; 70(9):1079-90A

Abstract

In older children, adolescents, and adults, a substantial part of all IgE-mediated food allergies is caused by cross-reacting allergenic structures shared by inhalants and foods. IgE stimulated by a cross-reactive inhalant allergen can result in diverse patterns of allergic reactions to various foods. Local, mild, or severe systemic reactions may occur already after the first consumption of a food containing a cross-reactive allergen. In clinical practice, clinically relevant sensitizations are elucidated by skin prick testing or by the determination of specific IgE in vitro. Component-resolved diagnosis may help to reach a diagnosis and may predict the risk of a systemic reaction. Allergy needs to be confirmed in cases of unclear history by oral challenge tests. The therapeutic potential of allergen immunotherapy with inhalant allergens in pollen-related food allergy is not clear, and more placebo-controlled studies are needed. As we are facing an increasing incidence of pollen allergies, a shift in sensitization patterns and changes in nutritional habits, and the occurrence of new, so far unknown allergies due to cross-reactions are expected.

Authors+Show Affiliations

Department of Dermatology and Allergy, Hannover Medical University, Hannover, Germany.Ambulatorio di Allergologia, Clinica San Carlo, Paderno Dugnano, Milan, Italy.Allergy Unit, Department of Dermatology, University Hospital Zürich, Zürich, Switzerland.Division of Paediatric Pneumology and Immunology, Charité University Hospital, Berlin, Germany.Allergy Division, Hospital General de Castellón, Castellón, Spain.Department of Dermatology/Allergology, University Medical Center Utrecht, Utrecht, The Netherlands.Associated Center for Molecular Allergology (CAAM), Latina, Italy.The Referral Centre for Food Allergy Diagnosis and Treatment Veneto Region, Department of Mother and Child Health, University of Padua, Padua, Italy.Department of Infection and Immunity, Luxembourg Institute of Health, Esch-sur-Alzette, Luxembourg and Department of Dermatology and Allergy, Biederstein, Technische Universität München (TUM), Munich, Germany.Allergy Clinic Copenhagen University Hospital at Gentofte, Copenhagen, Denmark.Division of Allergology, Paul-Ehrlich Institute, Langen, Germany.Department of Dermatology and Allergy, of Charité - Universitätsmedizin Berlin, Berlin, Germany.Department of Pathophysiology and Allergy Research, Medical University of Vienna, Vienna, Austria.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

26095197

Citation

Werfel, T, et al. "Position Paper of the EAACI: Food Allergy Due to Immunological Cross-reactions With Common Inhalant Allergens." Allergy, vol. 70, no. 9, 2015, pp. 1079-90.
Werfel T, Asero R, Ballmer-Weber BK, et al. Position paper of the EAACI: food allergy due to immunological cross-reactions with common inhalant allergens. Allergy. 2015;70(9):1079-90.
Werfel, T., Asero, R., Ballmer-Weber, B. K., Beyer, K., Enrique, E., Knulst, A. C., ... Hoffmann-Sommergruber, K. (2015). Position paper of the EAACI: food allergy due to immunological cross-reactions with common inhalant allergens. Allergy, 70(9), pp. 1079-90. doi:10.1111/all.12666.
Werfel T, et al. Position Paper of the EAACI: Food Allergy Due to Immunological Cross-reactions With Common Inhalant Allergens. Allergy. 2015;70(9):1079-90. PubMed PMID: 26095197.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Position paper of the EAACI: food allergy due to immunological cross-reactions with common inhalant allergens. AU - Werfel,T, AU - Asero,R, AU - Ballmer-Weber,B K, AU - Beyer,K, AU - Enrique,E, AU - Knulst,A C, AU - Mari,A, AU - Muraro,A, AU - Ollert,M, AU - Poulsen,L K, AU - Vieths,S, AU - Worm,M, AU - Hoffmann-Sommergruber,K, Y1 - 2015/07/07/ PY - 2015/06/04/accepted PY - 2015/6/23/entrez PY - 2015/6/23/pubmed PY - 2016/5/25/medline KW - IgE KW - allergens KW - cross-reactive KW - food allergy KW - inhalant KW - sensitization SP - 1079 EP - 90 JF - Allergy JO - Allergy VL - 70 IS - 9 N2 - In older children, adolescents, and adults, a substantial part of all IgE-mediated food allergies is caused by cross-reacting allergenic structures shared by inhalants and foods. IgE stimulated by a cross-reactive inhalant allergen can result in diverse patterns of allergic reactions to various foods. Local, mild, or severe systemic reactions may occur already after the first consumption of a food containing a cross-reactive allergen. In clinical practice, clinically relevant sensitizations are elucidated by skin prick testing or by the determination of specific IgE in vitro. Component-resolved diagnosis may help to reach a diagnosis and may predict the risk of a systemic reaction. Allergy needs to be confirmed in cases of unclear history by oral challenge tests. The therapeutic potential of allergen immunotherapy with inhalant allergens in pollen-related food allergy is not clear, and more placebo-controlled studies are needed. As we are facing an increasing incidence of pollen allergies, a shift in sensitization patterns and changes in nutritional habits, and the occurrence of new, so far unknown allergies due to cross-reactions are expected. SN - 1398-9995 UR - https://www.unboundmedicine.com/medline/citation/26095197/Position_paper_of_the_EAACI:_food_allergy_due_to_immunological_cross_reactions_with_common_inhalant_allergens_ L2 - https://doi.org/10.1111/all.12666 DB - PRIME DP - Unbound Medicine ER -