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Gaseous mediators in resolution of inflammation.
Semin Immunol. 2015 May; 27(3):227-33.SI

Abstract

There are numerous gaseous substances that can act as signaling molecules, but the best characterized of these are nitric oxide, hydrogen sulfide and carbon monoxide. Each has been shown to play important roles in many physiological and pathophysiological processes. This article is focused on the effects of these gasotransmitters in the context of inflammation. There is considerable overlap in the actions of nitric oxide, hydrogen sulfide and carbon monoxide with respect to inflammation, and these mediators appear to act primarily as anti-inflammatory substances, promoting resolution of inflammatory processes. They also have protective and pro-healing effects in some tissues, such as the gastrointestinal tract and lung. Over the past two decades, significant progress has been made in the development of novel anti-inflammatory and cytoprotective drugs that release of one or more of these gaseous mediators.

Authors+Show Affiliations

Department of Physiology & Pharmacology, University of Calgary, Calgary, Alberta, Canada. Electronic address: altapharm@hotmail.com.Department of Experimental Pharmacology, University of Naples, Naples, Italy.Institute for Biomedical Sciences, Georgia State University, Atlanta, GA, USA.Department of Experimental Pharmacology, University of Naples, Naples, Italy.

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

26095908

Citation

Wallace, John L., et al. "Gaseous Mediators in Resolution of Inflammation." Seminars in Immunology, vol. 27, no. 3, 2015, pp. 227-33.
Wallace JL, Ianaro A, Flannigan KL, et al. Gaseous mediators in resolution of inflammation. Semin Immunol. 2015;27(3):227-33.
Wallace, J. L., Ianaro, A., Flannigan, K. L., & Cirino, G. (2015). Gaseous mediators in resolution of inflammation. Seminars in Immunology, 27(3), 227-33. https://doi.org/10.1016/j.smim.2015.05.004
Wallace JL, et al. Gaseous Mediators in Resolution of Inflammation. Semin Immunol. 2015;27(3):227-33. PubMed PMID: 26095908.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Gaseous mediators in resolution of inflammation. AU - Wallace,John L, AU - Ianaro,Angela, AU - Flannigan,Kyle L, AU - Cirino,Giuseppe, Y1 - 2015/06/18/ PY - 2015/03/31/received PY - 2015/05/01/accepted PY - 2015/6/23/entrez PY - 2015/6/23/pubmed PY - 2016/4/26/medline KW - Anti-inflammatory KW - Carbon monoxide KW - Cytoprotection KW - Hydrogen sulfide KW - Nitric oxide SP - 227 EP - 33 JF - Seminars in immunology JO - Semin Immunol VL - 27 IS - 3 N2 - There are numerous gaseous substances that can act as signaling molecules, but the best characterized of these are nitric oxide, hydrogen sulfide and carbon monoxide. Each has been shown to play important roles in many physiological and pathophysiological processes. This article is focused on the effects of these gasotransmitters in the context of inflammation. There is considerable overlap in the actions of nitric oxide, hydrogen sulfide and carbon monoxide with respect to inflammation, and these mediators appear to act primarily as anti-inflammatory substances, promoting resolution of inflammatory processes. They also have protective and pro-healing effects in some tissues, such as the gastrointestinal tract and lung. Over the past two decades, significant progress has been made in the development of novel anti-inflammatory and cytoprotective drugs that release of one or more of these gaseous mediators. SN - 1096-3618 UR - https://www.unboundmedicine.com/medline/citation/26095908/Gaseous_mediators_in_resolution_of_inflammation_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1044-5323(15)00048-2 DB - PRIME DP - Unbound Medicine ER -