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Evaluation of oxidative events and copper accumulatıon in oral tissues of patients wıth Wilson's disease: three case report.
Int J Clin Exp Pathol. 2015; 8(4):3943-5.IJ

Abstract

Wilson's disease (WD), also known as hepatolenticular degeneration, was first described in 1912 by Kinnear Wilson. It is an autosomal recessive disorder caused by mutations in the ATP7B gene, a membrane-bound copper transporting ATPase. The disorder is caused by impairment of the copper transporting ATPase, ATP7B, in the liver, which disturbs copper transport, excretion into the bile, and incorporation into apoceruloplasmin. WD is an inherited copper metabolism disorder with pathological copper accumulation in many tissues, but especially in brain and liver. We conducted this study because copper accumulation in oral tissues in patients with WD have not been studied before. We think that copper accumulation and differences of oxidative events in oral tissues can cause tendency to periodontal diseases.

Authors+Show Affiliations

Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, Gazi University Ankara, Turkey.Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, Gazi University Ankara, Turkey.Department of Oral and Dentomaxillofacial Radiology, Faculty of Dentistry, Gazi University Ankara, Turkey.Department of Biology, Faculty of Science and Literature, Gazi University Ankara, Turkey.Department of Oral and Maxillofacial Surgery, Antera Dental Clinic Antalya, Turkey.

Pub Type(s)

Case Reports
Journal Article

Language

eng

PubMed ID

26097579

Citation

Ozturk, Mustafa, et al. "Evaluation of Oxidative Events and Copper Accumulatıon in Oral Tissues of Patients Wıth Wilson's Disease: Three Case Report." International Journal of Clinical and Experimental Pathology, vol. 8, no. 4, 2015, pp. 3943-5.
Ozturk M, Karacelebi E, Gungor K, et al. Evaluation of oxidative events and copper accumulatıon in oral tissues of patients wıth Wilson's disease: three case report. Int J Clin Exp Pathol. 2015;8(4):3943-5.
Ozturk, M., Karacelebi, E., Gungor, K., Coskun, S., & Boysan, E. (2015). Evaluation of oxidative events and copper accumulatıon in oral tissues of patients wıth Wilson's disease: three case report. International Journal of Clinical and Experimental Pathology, 8(4), 3943-5.
Ozturk M, et al. Evaluation of Oxidative Events and Copper Accumulatıon in Oral Tissues of Patients Wıth Wilson's Disease: Three Case Report. Int J Clin Exp Pathol. 2015;8(4):3943-5. PubMed PMID: 26097579.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Evaluation of oxidative events and copper accumulatıon in oral tissues of patients wıth Wilson's disease: three case report. AU - Ozturk,Mustafa, AU - Karacelebi,Ezgi, AU - Gungor,Kahraman, AU - Coskun,Sule, AU - Boysan,Esma, Y1 - 2015/04/01/ PY - 2015/01/21/received PY - 2015/03/20/accepted PY - 2015/6/23/entrez PY - 2015/6/23/pubmed PY - 2016/4/7/medline KW - Wilson’s disease KW - copper KW - hepatolenticular degeneration KW - penicillamine SP - 3943 EP - 5 JF - International journal of clinical and experimental pathology JO - Int J Clin Exp Pathol VL - 8 IS - 4 N2 - Wilson's disease (WD), also known as hepatolenticular degeneration, was first described in 1912 by Kinnear Wilson. It is an autosomal recessive disorder caused by mutations in the ATP7B gene, a membrane-bound copper transporting ATPase. The disorder is caused by impairment of the copper transporting ATPase, ATP7B, in the liver, which disturbs copper transport, excretion into the bile, and incorporation into apoceruloplasmin. WD is an inherited copper metabolism disorder with pathological copper accumulation in many tissues, but especially in brain and liver. We conducted this study because copper accumulation in oral tissues in patients with WD have not been studied before. We think that copper accumulation and differences of oxidative events in oral tissues can cause tendency to periodontal diseases. SN - 1936-2625 UR - https://www.unboundmedicine.com/medline/citation/26097579/Evaluation_of_oxidative_events_and_copper_accumulatıon_in_oral_tissues_of_patients_wıth_Wilson's_disease:_three_case_report_ L2 - https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/26097579/ DB - PRIME DP - Unbound Medicine ER -