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GDM Women's Pre-Pregnancy Overweight/Obesity and Gestational Weight Gain on Offspring Overweight Status.
PLoS One 2015; 10(6):e0129536Plos

Abstract

OBJECTIVES

To examine the association of maternal pre-pregnancy body mass index (BMI) and gestational weight gain (GWG) with anthropometry in the offspring of mothers with gestational diabetes mellitus (GDM).

METHODS

We performed a retrospective cohort study in 1263 GDM mother-child pairs. General linear models and Logistic regression models were used to assess the single and joint associations of maternal pre-pregnancy BMI (normal weight, overweight, and obesity) and GWG (inadequate, adequate and excessive GWG) with anthropometry and overweight status in the offspring from birth to 1-5 years old.

RESULTS

Maternal pre-pregnancy BMI and GWG were positively associated with birth weight for gestational age Z score and birth weight for length for gestational age Z score at birth, and weight for age Z score, length/height for age Z score, and weight for length/height Z score at of 1-5 years old offspring. Maternal pre-pregnancy overweight, obesity, and excessive GWG were associated with increased risks of large for gestational age [ORs 95% CIs = 1.87 (1.37-2.55), 2.98 (1.89-4.69), and 2.93 (2.07-4.13), respectively] and macrosomia [ORs 95% CIs = 2.06 (1.50-2.84), 2.89 (1.78-4.70), and 2.84 (1.98-4.06), respectively] at birth and childhood overweight at 1-5 years old [ORs 95% CIs = 1.26 (0.92-1.73), 1.96 (1.24-3.09), and 1.59 (1.15-2.21), respectively].

CONCLUSIONS

Offspring born to GDM mothers with pre-pregnancy overweight/obesity or excessive GWG were associated with increased risks of large for gestational age and macrosomia at birth, and childhood overweight at 1-5 years old, compared with those born to GDM mothers with pre-pregnancy normal weight and adequate GWG.

Authors+Show Affiliations

Project Office, Tianjin Women's and Children's Health Center, Tianjin, China.Project Office, Tianjin Women's and Children's Health Center, Tianjin, China; Chronic Disease Epidemiology Laboratory, Pennington Biomedical Research Center, Baton Rouge, Louisiana, United States of America.Project Office, Tianjin Women's and Children's Health Center, Tianjin, China.Project Office, Tianjin Women's and Children's Health Center, Tianjin, China.Project Office, Tianjin Women's and Children's Health Center, Tianjin, China.Project Office, Tianjin Women's and Children's Health Center, Tianjin, China.Project Office, Tianjin Women's and Children's Health Center, Tianjin, China.Chronic Disease Epidemiology Laboratory, Pennington Biomedical Research Center, Baton Rouge, Louisiana, United States of America.Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts, United States of America; Department of Environmental Health, Harvard School of Public Health, Boston, Massachusetts, United States of America.Department of Preventive Medicine, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, United States of America.Chronic Disease Epidemiology Laboratory, Pennington Biomedical Research Center, Baton Rouge, Louisiana, United States of America.

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

26098307

Citation

Leng, Junhong, et al. "GDM Women's Pre-Pregnancy Overweight/Obesity and Gestational Weight Gain On Offspring Overweight Status." PloS One, vol. 10, no. 6, 2015, pp. e0129536.
Leng J, Li W, Zhang S, et al. GDM Women's Pre-Pregnancy Overweight/Obesity and Gestational Weight Gain on Offspring Overweight Status. PLoS ONE. 2015;10(6):e0129536.
Leng, J., Li, W., Zhang, S., Liu, H., Wang, L., Liu, G., ... Hu, G. (2015). GDM Women's Pre-Pregnancy Overweight/Obesity and Gestational Weight Gain on Offspring Overweight Status. PloS One, 10(6), pp. e0129536. doi:10.1371/journal.pone.0129536.
Leng J, et al. GDM Women's Pre-Pregnancy Overweight/Obesity and Gestational Weight Gain On Offspring Overweight Status. PLoS ONE. 2015;10(6):e0129536. PubMed PMID: 26098307.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - GDM Women's Pre-Pregnancy Overweight/Obesity and Gestational Weight Gain on Offspring Overweight Status. AU - Leng,Junhong, AU - Li,Weiqin, AU - Zhang,Shuang, AU - Liu,Huikun, AU - Wang,Leishen, AU - Liu,Gongshu, AU - Li,Nan, AU - Redman,Leanne M, AU - Baccarelli,Andrea A, AU - Hou,Lifang, AU - Hu,Gang, Y1 - 2015/06/22/ PY - 2014/10/13/received PY - 2015/05/11/accepted PY - 2015/6/23/entrez PY - 2015/6/23/pubmed PY - 2016/3/24/medline SP - e0129536 EP - e0129536 JF - PloS one JO - PLoS ONE VL - 10 IS - 6 N2 - OBJECTIVES: To examine the association of maternal pre-pregnancy body mass index (BMI) and gestational weight gain (GWG) with anthropometry in the offspring of mothers with gestational diabetes mellitus (GDM). METHODS: We performed a retrospective cohort study in 1263 GDM mother-child pairs. General linear models and Logistic regression models were used to assess the single and joint associations of maternal pre-pregnancy BMI (normal weight, overweight, and obesity) and GWG (inadequate, adequate and excessive GWG) with anthropometry and overweight status in the offspring from birth to 1-5 years old. RESULTS: Maternal pre-pregnancy BMI and GWG were positively associated with birth weight for gestational age Z score and birth weight for length for gestational age Z score at birth, and weight for age Z score, length/height for age Z score, and weight for length/height Z score at of 1-5 years old offspring. Maternal pre-pregnancy overweight, obesity, and excessive GWG were associated with increased risks of large for gestational age [ORs 95% CIs = 1.87 (1.37-2.55), 2.98 (1.89-4.69), and 2.93 (2.07-4.13), respectively] and macrosomia [ORs 95% CIs = 2.06 (1.50-2.84), 2.89 (1.78-4.70), and 2.84 (1.98-4.06), respectively] at birth and childhood overweight at 1-5 years old [ORs 95% CIs = 1.26 (0.92-1.73), 1.96 (1.24-3.09), and 1.59 (1.15-2.21), respectively]. CONCLUSIONS: Offspring born to GDM mothers with pre-pregnancy overweight/obesity or excessive GWG were associated with increased risks of large for gestational age and macrosomia at birth, and childhood overweight at 1-5 years old, compared with those born to GDM mothers with pre-pregnancy normal weight and adequate GWG. SN - 1932-6203 UR - https://www.unboundmedicine.com/medline/citation/26098307/GDM_Women's_Pre_Pregnancy_Overweight/Obesity_and_Gestational_Weight_Gain_on_Offspring_Overweight_Status_ L2 - http://dx.plos.org/10.1371/journal.pone.0129536 DB - PRIME DP - Unbound Medicine ER -