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Effects of Omega-3 Polyunsaturated Fatty Acid Supplementation on Bone Turnover in Older Women.
Int J Vitam Nutr Res. 2014; 84(3-4):124-32.IJ

Abstract

Animal and human studies indicate that omega (n)-3 polyunsaturated fatty acids (PUFA) can influence bone health. We conducted a randomized, double-blind, placebo-controlled trial of the effects of n-3 long chain (LC) PUFA supplementation (N-3 LCPUFA) on red blood cell (RBC) fatty acid levels and bone turnover markers in older postmenopausal women. One hundred and twenty-six postmenopausal women (mean age 75±7 years) were treated with n-3 LCPUFA (1.2 g eicosapentaenoic acid [EPA]/docosahexaenoic acid [DHA]/day, n=85) or placebo (olive oil, n=41) for 6 months. All women received 315 mg calcium citrate and 1000 IU cholecalciferol. RBC DHA (weight %) increased in the n-3 LCPUFA group, compared to no change in the placebo group (P<0.001). The ratio of DHA+EPA:arachidonic acid (AA) increased by 42 % in the n-3 LCPUFA group and by 5% in the placebo group (P<0.001). Bone-specific alkaline phosphatase and osteocalcin decreased in the n-3 LCPUFA group (P<0.05) with no between-group difference. Short-term n-3 LCPUFA supplementation increased RBC concentrations of DHA and n-3:n-6 ratios. Bone turnover decreased with n-3 LCPUF, but not statistically compared to placebo. The results point to the need for investigations with greater dosages of n-3 LCPUFA for a longer duration to understand the contribution to bone metabolism in postmenopausal women.

Authors+Show Affiliations

1 Department of Cell Biology, University of Connecticut Health Center, Farmington, CT, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Randomized Controlled Trial
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

26098476

Citation

Dong, Hongli, et al. "Effects of Omega-3 Polyunsaturated Fatty Acid Supplementation On Bone Turnover in Older Women." International Journal for Vitamin and Nutrition Research. Internationale Zeitschrift Fur Vitamin- Und Ernahrungsforschung. Journal International De Vitaminologie Et De Nutrition, vol. 84, no. 3-4, 2014, pp. 124-32.
Dong H, Hutchins-Wiese H, Kleppinger A, et al. Effects of Omega-3 Polyunsaturated Fatty Acid Supplementation on Bone Turnover in Older Women. Int J Vitam Nutr Res. 2014;84(3-4):124-32.
Dong, H., Hutchins-Wiese, H., Kleppinger, A., Annis, K., Liva, E., Lammi-Keefe, C., Durham, H., Feinn, R., & Kenny, A. M. (2014). Effects of Omega-3 Polyunsaturated Fatty Acid Supplementation on Bone Turnover in Older Women. International Journal for Vitamin and Nutrition Research. Internationale Zeitschrift Fur Vitamin- Und Ernahrungsforschung. Journal International De Vitaminologie Et De Nutrition, 84(3-4), 124-32. https://doi.org/10.1024/0300-9831/a000199
Dong H, et al. Effects of Omega-3 Polyunsaturated Fatty Acid Supplementation On Bone Turnover in Older Women. Int J Vitam Nutr Res. 2014;84(3-4):124-32. PubMed PMID: 26098476.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effects of Omega-3 Polyunsaturated Fatty Acid Supplementation on Bone Turnover in Older Women. AU - Dong,Hongli, AU - Hutchins-Wiese,Heather, AU - Kleppinger,Alison, AU - Annis,Kristen, AU - Liva,Enrico, AU - Lammi-Keefe,Carol, AU - Durham,Holiday, AU - Feinn,Richard, AU - Kenny,Anne M, PY - 2015/6/23/entrez PY - 2015/6/23/pubmed PY - 2015/8/8/medline KW - bone turnover KW - fish oil KW - low bone mass KW - omega-3 fatty acids KW - osteoporosis KW - postmenopausal women SP - 124 EP - 32 JF - International journal for vitamin and nutrition research. Internationale Zeitschrift fur Vitamin- und Ernahrungsforschung. Journal international de vitaminologie et de nutrition JO - Int J Vitam Nutr Res VL - 84 IS - 3-4 N2 - Animal and human studies indicate that omega (n)-3 polyunsaturated fatty acids (PUFA) can influence bone health. We conducted a randomized, double-blind, placebo-controlled trial of the effects of n-3 long chain (LC) PUFA supplementation (N-3 LCPUFA) on red blood cell (RBC) fatty acid levels and bone turnover markers in older postmenopausal women. One hundred and twenty-six postmenopausal women (mean age 75±7 years) were treated with n-3 LCPUFA (1.2 g eicosapentaenoic acid [EPA]/docosahexaenoic acid [DHA]/day, n=85) or placebo (olive oil, n=41) for 6 months. All women received 315 mg calcium citrate and 1000 IU cholecalciferol. RBC DHA (weight %) increased in the n-3 LCPUFA group, compared to no change in the placebo group (P<0.001). The ratio of DHA+EPA:arachidonic acid (AA) increased by 42 % in the n-3 LCPUFA group and by 5% in the placebo group (P<0.001). Bone-specific alkaline phosphatase and osteocalcin decreased in the n-3 LCPUFA group (P<0.05) with no between-group difference. Short-term n-3 LCPUFA supplementation increased RBC concentrations of DHA and n-3:n-6 ratios. Bone turnover decreased with n-3 LCPUF, but not statistically compared to placebo. The results point to the need for investigations with greater dosages of n-3 LCPUFA for a longer duration to understand the contribution to bone metabolism in postmenopausal women. SN - 0300-9831 UR - https://www.unboundmedicine.com/medline/citation/26098476/Effects_of_Omega_3_Polyunsaturated_Fatty_Acid_Supplementation_on_Bone_Turnover_in_Older_Women_ L2 - https://econtent.hogrefe.com/doi/10.1024/0300-9831/a000199?url_ver=Z39.88-2003&amp;rfr_id=ori:rid:crossref.org&amp;rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -