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Higher Dietary Acidity is Associated with Lower Bone Mineral Density in Postmenopausal Iranian Women, Independent of Dietary Calcium Intake.
Int J Vitam Nutr Res 2014; 84(3-4):206-17IJ

Abstract

Findings of studies on the link between dietary acid-base balance and bone mass are relatively mixed. We examined the association between dietary acid-base balance and bone mineral density (BMD) in a sample of Iranian women, hypothesizing that a higher dietary acidity would be inversely associated with BMD, even when dietary calcium intake is adequate. In this cross-sectional study, lumbar spine and femoral neck BMDs of 151 postmenopausal women aged 50-85 years were measured using dual-energy x-ray absorptiometry. Dietary intakes were assessed using a validated food frequency questionnaire. Renal net acid excretion (RNAE), an estimate of acid-base balance, was then calculated indirectly from the diet using the formulae of Remer (based on dietary intakes of protein, phosphorus, potassium, and magnesium; RNAERemer) and Frassetto (based on dietary intakes of protein and potassium; RNAEFrassetto), and was energy adjusted by the residual method. After adjusting for potential confounders, multivariable adjusted means of the lumbar spine BMD of women in the highest tertiles of RNAERemer and RNAEFrassetto were significantly lower than those in the lowest tertiles (for RNAERemer: mean difference -0.084 g/cm2; P=0.007 and for RNAEFrassetto: mean difference -0.088 g/cm2; P=0.004). Similar results were observed in a subgroup analysis of subjects with dietary calcium intake of >800 mg/day. In conclusion, a higher RNAE (i. e. more dietary acidity), which is associated with greater intake of acid-generating foods and lower intake of alkali-generating foods, may be involved in deteriorating the bone health of postmenopausal Iranian women, even in the context of adequate dietary calcium intake.

Authors+Show Affiliations

1 Department of Nutrition Sciences, Varastegan Institute for Medical Sciences, Mashhad, Iran.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

26098484

Citation

Shariati-Bafghi, Seyedeh-Elaheh, et al. "Higher Dietary Acidity Is Associated With Lower Bone Mineral Density in Postmenopausal Iranian Women, Independent of Dietary Calcium Intake." International Journal for Vitamin and Nutrition Research. Internationale Zeitschrift Fur Vitamin- Und Ernahrungsforschung. Journal International De Vitaminologie Et De Nutrition, vol. 84, no. 3-4, 2014, pp. 206-17.
Shariati-Bafghi SE, Nosrat-Mirshekarlou E, Karamati M, et al. Higher Dietary Acidity is Associated with Lower Bone Mineral Density in Postmenopausal Iranian Women, Independent of Dietary Calcium Intake. Int J Vitam Nutr Res. 2014;84(3-4):206-17.
Shariati-Bafghi, S. E., Nosrat-Mirshekarlou, E., Karamati, M., & Rashidkhani, B. (2014). Higher Dietary Acidity is Associated with Lower Bone Mineral Density in Postmenopausal Iranian Women, Independent of Dietary Calcium Intake. International Journal for Vitamin and Nutrition Research. Internationale Zeitschrift Fur Vitamin- Und Ernahrungsforschung. Journal International De Vitaminologie Et De Nutrition, 84(3-4), pp. 206-17. doi:10.1024/0300-9831/a000207.
Shariati-Bafghi SE, et al. Higher Dietary Acidity Is Associated With Lower Bone Mineral Density in Postmenopausal Iranian Women, Independent of Dietary Calcium Intake. Int J Vitam Nutr Res. 2014;84(3-4):206-17. PubMed PMID: 26098484.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Higher Dietary Acidity is Associated with Lower Bone Mineral Density in Postmenopausal Iranian Women, Independent of Dietary Calcium Intake. AU - Shariati-Bafghi,Seyedeh-Elaheh, AU - Nosrat-Mirshekarlou,Elaheh, AU - Karamati,Mohsen, AU - Rashidkhani,Bahram, PY - 2015/6/23/entrez PY - 2015/6/23/pubmed PY - 2015/8/8/medline KW - Iran KW - acid-base balance KW - bone mineral density KW - calcium KW - diet KW - post-menopause SP - 206 EP - 17 JF - International journal for vitamin and nutrition research. Internationale Zeitschrift fur Vitamin- und Ernahrungsforschung. Journal international de vitaminologie et de nutrition JO - Int J Vitam Nutr Res VL - 84 IS - 3-4 N2 - Findings of studies on the link between dietary acid-base balance and bone mass are relatively mixed. We examined the association between dietary acid-base balance and bone mineral density (BMD) in a sample of Iranian women, hypothesizing that a higher dietary acidity would be inversely associated with BMD, even when dietary calcium intake is adequate. In this cross-sectional study, lumbar spine and femoral neck BMDs of 151 postmenopausal women aged 50-85 years were measured using dual-energy x-ray absorptiometry. Dietary intakes were assessed using a validated food frequency questionnaire. Renal net acid excretion (RNAE), an estimate of acid-base balance, was then calculated indirectly from the diet using the formulae of Remer (based on dietary intakes of protein, phosphorus, potassium, and magnesium; RNAERemer) and Frassetto (based on dietary intakes of protein and potassium; RNAEFrassetto), and was energy adjusted by the residual method. After adjusting for potential confounders, multivariable adjusted means of the lumbar spine BMD of women in the highest tertiles of RNAERemer and RNAEFrassetto were significantly lower than those in the lowest tertiles (for RNAERemer: mean difference -0.084 g/cm2; P=0.007 and for RNAEFrassetto: mean difference -0.088 g/cm2; P=0.004). Similar results were observed in a subgroup analysis of subjects with dietary calcium intake of >800 mg/day. In conclusion, a higher RNAE (i. e. more dietary acidity), which is associated with greater intake of acid-generating foods and lower intake of alkali-generating foods, may be involved in deteriorating the bone health of postmenopausal Iranian women, even in the context of adequate dietary calcium intake. SN - 0300-9831 UR - https://www.unboundmedicine.com/medline/citation/26098484/Higher_Dietary_Acidity_is_Associated_with_Lower_Bone_Mineral_Density_in_Postmenopausal_Iranian_Women_Independent_of_Dietary_Calcium_Intake_ L2 - http://econtent.hogrefe.com/doi/full/10.1024/0300-9831/a000207?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -