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Significance of selenium in thyroid physiology and pathology.
Pol Merkur Lekarski 2015; 38(228):348-53PM

Abstract

Selenium is pivotal element in maintaining homeostasis of human body. It is capable of exerting an influence on immunological responses, cell growth and viral defence. Nevertheless, it is mostly required for the proper thyroid function. There were described 25 selenoproteins, which play various roles in human body. Selenium is an essential particle in the active site of enzymes such as GPXs (glutathione peroxidases), Ds (deiodinases) and TRs (thioredoxin reductases). Owing to this, it has a fundamental importance in the synthesis and function of thyroid hormones, and protects cells against free radicals and oxidative damage. Intake of selenium necessary to maintain suitable selenoenzyme activity ranges from 60 μg to 75 μg per day. Selenium deficiency contributes to decreased activity of GPXs, which can lead to oxidative damage, or Ds, which is connected with impaired thyroid activity. Moreover, a low selenium concentration causes autoimmune processes in the thyroid gland, thus selenium deficiency is essential in pathogenesis of autoimmune thyroiditis or Graves' disease. Because of regulation of the cell cycle, a decreased concentration of selenium impacts on the development of thyroid cancer.

Authors+Show Affiliations

Medical University of Poznan, Poland: Department of Endocrinology, Metabolism and Internal Medicine.Medical University of Poznan, Poland: Student's Scientific Society.

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

26098657

Citation

Lacka, Katarzyna, and Anna Szeliga. "Significance of Selenium in Thyroid Physiology and Pathology." Polski Merkuriusz Lekarski : Organ Polskiego Towarzystwa Lekarskiego, vol. 38, no. 228, 2015, pp. 348-53.
Lacka K, Szeliga A. Significance of selenium in thyroid physiology and pathology. Pol Merkur Lekarski. 2015;38(228):348-53.
Lacka, K., & Szeliga, A. (2015). Significance of selenium in thyroid physiology and pathology. Polski Merkuriusz Lekarski : Organ Polskiego Towarzystwa Lekarskiego, 38(228), pp. 348-53.
Lacka K, Szeliga A. Significance of Selenium in Thyroid Physiology and Pathology. Pol Merkur Lekarski. 2015;38(228):348-53. PubMed PMID: 26098657.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Significance of selenium in thyroid physiology and pathology. AU - Lacka,Katarzyna, AU - Szeliga,Anna, PY - 2015/6/23/entrez PY - 2015/6/23/pubmed PY - 2015/8/22/medline KW - autoimmunity KW - selenium KW - thyroid SP - 348 EP - 53 JF - Polski merkuriusz lekarski : organ Polskiego Towarzystwa Lekarskiego JO - Pol. Merkur. Lekarski VL - 38 IS - 228 N2 - Selenium is pivotal element in maintaining homeostasis of human body. It is capable of exerting an influence on immunological responses, cell growth and viral defence. Nevertheless, it is mostly required for the proper thyroid function. There were described 25 selenoproteins, which play various roles in human body. Selenium is an essential particle in the active site of enzymes such as GPXs (glutathione peroxidases), Ds (deiodinases) and TRs (thioredoxin reductases). Owing to this, it has a fundamental importance in the synthesis and function of thyroid hormones, and protects cells against free radicals and oxidative damage. Intake of selenium necessary to maintain suitable selenoenzyme activity ranges from 60 μg to 75 μg per day. Selenium deficiency contributes to decreased activity of GPXs, which can lead to oxidative damage, or Ds, which is connected with impaired thyroid activity. Moreover, a low selenium concentration causes autoimmune processes in the thyroid gland, thus selenium deficiency is essential in pathogenesis of autoimmune thyroiditis or Graves' disease. Because of regulation of the cell cycle, a decreased concentration of selenium impacts on the development of thyroid cancer. SN - 1426-9686 UR - https://www.unboundmedicine.com/medline/citation/26098657/Significance_of_selenium_in_thyroid_physiology_and_pathology_ L2 - http://medpress.com.pl/pubmed.php?article=228348 DB - PRIME DP - Unbound Medicine ER -