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Parkinson's disease and insomnia.
Neurol Sci. 2015 Nov; 36(11):2003-10.NS

Abstract

There is a broad spectrum of sleep disturbances observed in Parkinson's disease (PD). The prevalence of symptoms of insomnia and chronic inability to sleep and their association with other sleep disorders were studied. Altogether 1447 randomly selected Parkinson patients, aged 43-89 years, participated in a questionnaire study. A structured questionnaire with 207 items was based on the Basic Nordic Sleep questionnaire. Questions on demographics, PD, REM Sleep Behavior Disorder, and other issues were included. The response rate was 59 % (N = 854), and of these 81 % returned fully answered questionnaire (N = 689). Prevalence of chronic inability to sleep was 36.9 % (95 % CI 33.3-40.5). Difficulty of initiating sleep was 18.0 % (95 % CI 15.1-20.9), disrupted sleep 81.54 % (78.5-84.4), awakenings during night 31.3 % (27.8-34.8), early morning awakenings 40.4 % (36.8-44.1) and non-restorative sleep 38.5 % (34.8-42.1). In the logistic regression models, poor quality of life and restless legs syndrome correlated significantly with chronic insomnia disorder. Disrupted sleep and early morning awakenings were the most common insomnia symptoms. PD patients do not seem to have difficulties in sleep initiation. Insomnia symptoms including disruptive sleep and non-restorative sleep are common in patients with Parkinson's disease. Inability to sleep is more common as comorbidity than a single sleep problem.

Authors+Show Affiliations

Vitalmed Research Center, Helsinki Sleep Clinic, Sitratori 3, 00420, Helsinki, Finland. ari.ylikoski@fimnet.fi. Department of Neurology, Hospital of Laakso, Helsinki, Finland. ari.ylikoski@fimnet.fi.The Finnish Parkinson Association, Turku, Finland.Department of Adult Neurology, Medical University of Gdansk, Gdansk, Poland.Vitalmed Research Center, Helsinki Sleep Clinic, Sitratori 3, 00420, Helsinki, Finland. Department of Clinical Neurosciences, Institute of Clinical Medicine, University of Helsinki, Helsinki, Finland.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

26099862

Citation

Ylikoski, Ari, et al. "Parkinson's Disease and Insomnia." Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology, vol. 36, no. 11, 2015, pp. 2003-10.
Ylikoski A, Martikainen K, Sieminski M, et al. Parkinson's disease and insomnia. Neurol Sci. 2015;36(11):2003-10.
Ylikoski, A., Martikainen, K., Sieminski, M., & Partinen, M. (2015). Parkinson's disease and insomnia. Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology, 36(11), 2003-10. https://doi.org/10.1007/s10072-015-2288-9
Ylikoski A, et al. Parkinson's Disease and Insomnia. Neurol Sci. 2015;36(11):2003-10. PubMed PMID: 26099862.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Parkinson's disease and insomnia. AU - Ylikoski,Ari, AU - Martikainen,Kirsti, AU - Sieminski,Mariusz, AU - Partinen,Markku, Y1 - 2015/06/23/ PY - 2015/05/03/received PY - 2015/06/11/accepted PY - 2015/6/24/entrez PY - 2015/6/24/pubmed PY - 2016/8/9/medline KW - Chronic insomnia KW - Parkinson’s disease KW - Quality of life KW - Restless legs syndrome KW - Sleep disorders SP - 2003 EP - 10 JF - Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology JO - Neurol Sci VL - 36 IS - 11 N2 - There is a broad spectrum of sleep disturbances observed in Parkinson's disease (PD). The prevalence of symptoms of insomnia and chronic inability to sleep and their association with other sleep disorders were studied. Altogether 1447 randomly selected Parkinson patients, aged 43-89 years, participated in a questionnaire study. A structured questionnaire with 207 items was based on the Basic Nordic Sleep questionnaire. Questions on demographics, PD, REM Sleep Behavior Disorder, and other issues were included. The response rate was 59 % (N = 854), and of these 81 % returned fully answered questionnaire (N = 689). Prevalence of chronic inability to sleep was 36.9 % (95 % CI 33.3-40.5). Difficulty of initiating sleep was 18.0 % (95 % CI 15.1-20.9), disrupted sleep 81.54 % (78.5-84.4), awakenings during night 31.3 % (27.8-34.8), early morning awakenings 40.4 % (36.8-44.1) and non-restorative sleep 38.5 % (34.8-42.1). In the logistic regression models, poor quality of life and restless legs syndrome correlated significantly with chronic insomnia disorder. Disrupted sleep and early morning awakenings were the most common insomnia symptoms. PD patients do not seem to have difficulties in sleep initiation. Insomnia symptoms including disruptive sleep and non-restorative sleep are common in patients with Parkinson's disease. Inability to sleep is more common as comorbidity than a single sleep problem. SN - 1590-3478 UR - https://www.unboundmedicine.com/medline/citation/26099862/Parkinson's_disease_and_insomnia_ DB - PRIME DP - Unbound Medicine ER -