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Iron concentrations in atherosclerotic plaque and serum in patients with carotid atherosclerosis.
Acta Physiol Hung. 2015 Jun; 102(2):143-50.AP

Abstract

The aim of this study was to investigate the iron concentrations in serum and carotid plaque in patients with different morphology of carotid atherosclerotic plaque and compared with other metal ions. Carotid endarterectomy due to the significant atherosclerotic stenosis was performed in 91 patients. Control group consisted of 27 patients, without carotid atherosclerosis. Atherosclerotic plaques were divided into four morphological groups, according to ultrasonic and intraoperative characteristics. Iron, copper and zinc concentration in plaque, carotid artery and serum were measured by spectrophotometry. Serum iron concentrations were higher in patients with hemorrhagic plaques in comparison to the control group (4.7 μmol/l ± 1.2 vs. 2.1 μmol/l ± 0.8, p < 0.05). Iron concentrations were higher in patients with hemorrhagic plaques in comparison to fibrolipid plaques (72.1 ± 14.3 μg/g vs. 39.3 ± 22.9 μg/g; p < 0.05). Negative significant correlation was found for zinc in serum and plaque iron concentration in patients (p < 0.05). We also demonstrated positive significant correlation for copper and iron in serum (p < 0.05). The data obtained in the current study are consistent with the hypothesis that high iron levels may contribute to atherosclerosis and its complications as factors in a multifactorial disease.

Authors+Show Affiliations

Dedinje Cardiovascular Institute, Faculty of Medicine, University of Belgrade , Belgrade , Serbia.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

26100304

Citation

Tasic, Nebojsa M., et al. "Iron Concentrations in Atherosclerotic Plaque and Serum in Patients With Carotid Atherosclerosis." Acta Physiologica Hungarica, vol. 102, no. 2, 2015, pp. 143-50.
Tasic NM, Tasic D, Veselinovic M, et al. Iron concentrations in atherosclerotic plaque and serum in patients with carotid atherosclerosis. Acta Physiol Hung. 2015;102(2):143-50.
Tasic, N. M., Tasic, D., Veselinovic, M., Jakovljevic, V., Djuric, D., & Radak, D. (2015). Iron concentrations in atherosclerotic plaque and serum in patients with carotid atherosclerosis. Acta Physiologica Hungarica, 102(2), 143-50. https://doi.org/10.1556/036.102.2015.2.5
Tasic NM, et al. Iron Concentrations in Atherosclerotic Plaque and Serum in Patients With Carotid Atherosclerosis. Acta Physiol Hung. 2015;102(2):143-50. PubMed PMID: 26100304.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Iron concentrations in atherosclerotic plaque and serum in patients with carotid atherosclerosis. AU - Tasic,Nebojsa M, AU - Tasic,D, AU - Veselinovic,M, AU - Jakovljevic,V, AU - Djuric,D, AU - Radak,D, PY - 2015/6/24/entrez PY - 2015/6/24/pubmed PY - 2015/8/13/medline KW - atherosclerosis KW - carotid plaque KW - copper KW - iron KW - zinc SP - 143 EP - 50 JF - Acta physiologica Hungarica JO - Acta Physiol Hung VL - 102 IS - 2 N2 - The aim of this study was to investigate the iron concentrations in serum and carotid plaque in patients with different morphology of carotid atherosclerotic plaque and compared with other metal ions. Carotid endarterectomy due to the significant atherosclerotic stenosis was performed in 91 patients. Control group consisted of 27 patients, without carotid atherosclerosis. Atherosclerotic plaques were divided into four morphological groups, according to ultrasonic and intraoperative characteristics. Iron, copper and zinc concentration in plaque, carotid artery and serum were measured by spectrophotometry. Serum iron concentrations were higher in patients with hemorrhagic plaques in comparison to the control group (4.7 μmol/l ± 1.2 vs. 2.1 μmol/l ± 0.8, p < 0.05). Iron concentrations were higher in patients with hemorrhagic plaques in comparison to fibrolipid plaques (72.1 ± 14.3 μg/g vs. 39.3 ± 22.9 μg/g; p < 0.05). Negative significant correlation was found for zinc in serum and plaque iron concentration in patients (p < 0.05). We also demonstrated positive significant correlation for copper and iron in serum (p < 0.05). The data obtained in the current study are consistent with the hypothesis that high iron levels may contribute to atherosclerosis and its complications as factors in a multifactorial disease. SN - 0231-424X UR - https://www.unboundmedicine.com/medline/citation/26100304/Iron_concentrations_in_atherosclerotic_plaque_and_serum_in_patients_with_carotid_atherosclerosis_ L2 - http://www.akademiai.com/doi/full/10.1556/036.102.2015.2.5?url_ver=Z39.88-2003&amp;rfr_id=ori:rid:crossref.org&amp;rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -