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Iron concentrations in atherosclerotic plaque and serum in patients with carotid atherosclerosis.

Abstract

The aim of this study was to investigate the iron concentrations in serum and carotid plaque in patients with different morphology of carotid atherosclerotic plaque and compared with other metal ions. Carotid endarterectomy due to the significant atherosclerotic stenosis was performed in 91 patients. Control group consisted of 27 patients, without carotid atherosclerosis. Atherosclerotic plaques were divided into four morphological groups, according to ultrasonic and intraoperative characteristics. Iron, copper and zinc concentration in plaque, carotid artery and serum were measured by spectrophotometry. Serum iron concentrations were higher in patients with hemorrhagic plaques in comparison to the control group (4.7 μmol/l ± 1.2 vs. 2.1 μmol/l ± 0.8, p < 0.05). Iron concentrations were higher in patients with hemorrhagic plaques in comparison to fibrolipid plaques (72.1 ± 14.3 μg/g vs. 39.3 ± 22.9 μg/g; p < 0.05). Negative significant correlation was found for zinc in serum and plaque iron concentration in patients (p < 0.05). We also demonstrated positive significant correlation for copper and iron in serum (p < 0.05). The data obtained in the current study are consistent with the hypothesis that high iron levels may contribute to atherosclerosis and its complications as factors in a multifactorial disease.

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  • Authors+Show Affiliations

    ,

    Dedinje Cardiovascular Institute, Faculty of Medicine, University of Belgrade , Belgrade , Serbia.

    , , , ,

    Source

    Acta physiologica Hungarica 102:2 2015 Jun pg 143-50

    MeSH

    Aged
    Biomarkers
    Carotid Arteries
    Carotid Artery Diseases
    Case-Control Studies
    Copper
    Endarterectomy, Carotid
    Female
    Fibrosis
    Hemorrhage
    Humans
    Iron
    Male
    Middle Aged
    Plaque, Atherosclerotic
    Ultrasonography
    Up-Regulation
    Zinc

    Pub Type(s)

    Journal Article

    Language

    eng

    PubMed ID

    26100304

    Citation

    Tasic, Nebojsa M., et al. "Iron Concentrations in Atherosclerotic Plaque and Serum in Patients With Carotid Atherosclerosis." Acta Physiologica Hungarica, vol. 102, no. 2, 2015, pp. 143-50.
    Tasic NM, Tasic D, Veselinovic M, et al. Iron concentrations in atherosclerotic plaque and serum in patients with carotid atherosclerosis. Acta Physiol Hung. 2015;102(2):143-50.
    Tasic, N. M., Tasic, D., Veselinovic, M., Jakovljevic, V., Djuric, D., & Radak, D. (2015). Iron concentrations in atherosclerotic plaque and serum in patients with carotid atherosclerosis. Acta Physiologica Hungarica, 102(2), pp. 143-50. doi:10.1556/036.102.2015.2.5.
    Tasic NM, et al. Iron Concentrations in Atherosclerotic Plaque and Serum in Patients With Carotid Atherosclerosis. Acta Physiol Hung. 2015;102(2):143-50. PubMed PMID: 26100304.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Iron concentrations in atherosclerotic plaque and serum in patients with carotid atherosclerosis. AU - Tasic,Nebojsa M, AU - Tasic,D, AU - Veselinovic,M, AU - Jakovljevic,V, AU - Djuric,D, AU - Radak,D, PY - 2015/6/24/entrez PY - 2015/6/24/pubmed PY - 2015/8/13/medline KW - atherosclerosis KW - carotid plaque KW - copper KW - iron KW - zinc SP - 143 EP - 50 JF - Acta physiologica Hungarica JO - Acta Physiol Hung VL - 102 IS - 2 N2 - The aim of this study was to investigate the iron concentrations in serum and carotid plaque in patients with different morphology of carotid atherosclerotic plaque and compared with other metal ions. Carotid endarterectomy due to the significant atherosclerotic stenosis was performed in 91 patients. Control group consisted of 27 patients, without carotid atherosclerosis. Atherosclerotic plaques were divided into four morphological groups, according to ultrasonic and intraoperative characteristics. Iron, copper and zinc concentration in plaque, carotid artery and serum were measured by spectrophotometry. Serum iron concentrations were higher in patients with hemorrhagic plaques in comparison to the control group (4.7 μmol/l ± 1.2 vs. 2.1 μmol/l ± 0.8, p < 0.05). Iron concentrations were higher in patients with hemorrhagic plaques in comparison to fibrolipid plaques (72.1 ± 14.3 μg/g vs. 39.3 ± 22.9 μg/g; p < 0.05). Negative significant correlation was found for zinc in serum and plaque iron concentration in patients (p < 0.05). We also demonstrated positive significant correlation for copper and iron in serum (p < 0.05). The data obtained in the current study are consistent with the hypothesis that high iron levels may contribute to atherosclerosis and its complications as factors in a multifactorial disease. SN - 0231-424X UR - https://www.unboundmedicine.com/medline/citation/26100304/Iron_concentrations_in_atherosclerotic_plaque_and_serum_in_patients_with_carotid_atherosclerosis_ L2 - http://www.akademiai.com/doi/full/10.1556/036.102.2015.2.5?url_ver=Z39.88-2003&amp;rfr_id=ori:rid:crossref.org&amp;rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -