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The mean platelet volume and neutrophil to lymphocyte ratio in obese and lean patients with polycystic ovary syndrome.
J Endocrinol Invest. 2016 Jan; 39(1):45-53.JE

Abstract

PURPOSE

Mean platelet volume (MPV) and neutrophil to lymphocyte ratio (NLR) are the new markers of the detection of inflammation. Our aim is to investigate MPV and NLR in lean and obese patients with polycystic ovary syndrome (PCOS).

METHODS

This study was designed to investigate MPV, NLR, and high-sensitive C-reactive protein (hsCRP) levels in 25 obese patients with PCOS and 16 lean patients with PCOS, and our study group was matched with 16 obese and 14 non-obese controls, respectively.

RESULTS

PCOS group had higher MPV, NLR, neutrophil count, neutrophil to total leucocyte ratio, basophil count, waist circumference (WC), insulin, glucose, and HOMA-IR rates than those of controls. hsCRP levels were similar in both groups. Subgroup analyses revealed that obese PCOS group had higher insulin and HOMA-IR levels, compared to those of controls. In this subgroup, total leucocyte counts, MPV, and hsCRP levels were similar. On the other hand, lean PCOS group had higher WC, NLR, MPV, and basophil count than controls. In correlation analysis, hsCRP was positively correlated with body mass index (BMI), WC, total leucocyte count, neutrophil count, while negatively correlated with lymphocyte ratio. Although leucocyte count was positively correlated with BMI, MPV was negatively correlated with BMI, total leucocyte, platelet, and neutrophil counts. NLR was positively correlated with HOMA-IR, hsCRP, BMI, WC, and insulin.

CONCLUSION

Our study demonstrated that MPV and NLR levels are increased despite similar hsCRP levels in patients with PCOS. However, we failed to demonstrate these differences in obese PCOS patients. Further studies with larger sample size are required to determine the significance of BMI in the inflammation of PCOS patients.

Links

Publisher Full Text (DOI)

Authors+Show Affiliations

Yilmaz MA
Department of Internal Medicine, Konya Training and Research Hospital, Konya, Turkey.
Duran C
Division of Endocrinology and Metabolism, Department of Internal Medicine, Clinic of Endocrinology and Metabolism, Konya Training and Research Hospital, 42100, Konya, Turkey. drcduran@gmail.com.
Basaran M
Department of Obstetrics and Gynecology, Konya Training and Research Hospital, Konya, Turkey.

MeSH

AdultBody Mass IndexC-Reactive ProteinCase-Control StudiesFemaleHumansLeukocyte CountLymphocyte CountLymphocytesMean Platelet VolumeNeutrophilsObesityPolycystic Ovary SyndromeThinnessWaist CircumferenceYoung Adult

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

26100531

Citation

Yilmaz, M A., et al. "The Mean Platelet Volume and Neutrophil to Lymphocyte Ratio in Obese and Lean Patients With Polycystic Ovary Syndrome." Journal of Endocrinological Investigation, vol. 39, no. 1, 2016, pp. 45-53.
Yilmaz MA, Duran C, Basaran M. The mean platelet volume and neutrophil to lymphocyte ratio in obese and lean patients with polycystic ovary syndrome. J Endocrinol Invest. 2016;39(1):45-53.
Yilmaz, M. A., Duran, C., & Basaran, M. (2016). The mean platelet volume and neutrophil to lymphocyte ratio in obese and lean patients with polycystic ovary syndrome. Journal of Endocrinological Investigation, 39(1), 45-53. https://doi.org/10.1007/s40618-015-0335-2
Yilmaz MA, Duran C, Basaran M. The Mean Platelet Volume and Neutrophil to Lymphocyte Ratio in Obese and Lean Patients With Polycystic Ovary Syndrome. J Endocrinol Invest. 2016;39(1):45-53. PubMed PMID: 26100531.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The mean platelet volume and neutrophil to lymphocyte ratio in obese and lean patients with polycystic ovary syndrome. AU - Yilmaz,M A, AU - Duran,C, AU - Basaran,M, Y1 - 2015/06/23/ PY - 2015/4/2/received PY - 2015/6/9/accepted PY - 2015/6/24/entrez PY - 2015/6/24/pubmed PY - 2016/11/12/medline KW - High-sensitive CRP KW - Mean platelet volume KW - Neutrophil to lymphocyte ratio KW - Polycystic ovary syndrome SP - 45 EP - 53 JF - Journal of endocrinological investigation JO - J Endocrinol Invest VL - 39 IS - 1 N2 - PURPOSE: Mean platelet volume (MPV) and neutrophil to lymphocyte ratio (NLR) are the new markers of the detection of inflammation. Our aim is to investigate MPV and NLR in lean and obese patients with polycystic ovary syndrome (PCOS). METHODS: This study was designed to investigate MPV, NLR, and high-sensitive C-reactive protein (hsCRP) levels in 25 obese patients with PCOS and 16 lean patients with PCOS, and our study group was matched with 16 obese and 14 non-obese controls, respectively. RESULTS: PCOS group had higher MPV, NLR, neutrophil count, neutrophil to total leucocyte ratio, basophil count, waist circumference (WC), insulin, glucose, and HOMA-IR rates than those of controls. hsCRP levels were similar in both groups. Subgroup analyses revealed that obese PCOS group had higher insulin and HOMA-IR levels, compared to those of controls. In this subgroup, total leucocyte counts, MPV, and hsCRP levels were similar. On the other hand, lean PCOS group had higher WC, NLR, MPV, and basophil count than controls. In correlation analysis, hsCRP was positively correlated with body mass index (BMI), WC, total leucocyte count, neutrophil count, while negatively correlated with lymphocyte ratio. Although leucocyte count was positively correlated with BMI, MPV was negatively correlated with BMI, total leucocyte, platelet, and neutrophil counts. NLR was positively correlated with HOMA-IR, hsCRP, BMI, WC, and insulin. CONCLUSION: Our study demonstrated that MPV and NLR levels are increased despite similar hsCRP levels in patients with PCOS. However, we failed to demonstrate these differences in obese PCOS patients. Further studies with larger sample size are required to determine the significance of BMI in the inflammation of PCOS patients. SN - 1720-8386 UR - https://www.unboundmedicine.com/medline/citation/26100531/The_mean_platelet_volume_and_neutrophil_to_lymphocyte_ratio_in_obese_and_lean_patients_with_polycystic_ovary_syndrome_ DB - PRIME DP - Unbound Medicine ER -