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Applicability of the New ESPGHAN Guidelines for Diagnosing Coeliac Disease in Children from Resource Limited Countries.
J Coll Physicians Surg Pak 2015; 25(6):455-7JC

Abstract

Coeliac Disease (CD) is an immune-mediated systemic disorder elicited by the ingestion of gluten. Small-bowel biopsies and histology has been the gold standard for diagnosing CD. The modified ESPGHAN guidelines recommend that in symptomatic children with anti-tissue-Transglutaminase (tTG) titre of > 10 times Upper-Limit-of-Normal (ULN), diagnosis of CD can be made without small-bowel biopsies. However, positive HLA-DQ2/DQ8 serotype and anti-Endomysial Antibodies (EMA) are necessary. Studies from resource-limited countries have demonstrated applicability of the ESPGHAN guidelines for serological diagnosis of CD. CD should not be diagnosed on the basis of a single high tTG-titre. Small-bowel biopsies are necessary for diagnosing CD in asymptomatic children and those with tTG-titre < 10 x ULN. Management of CD needs lifelong gluten free diet.

Authors+Show Affiliations

Department of Paediatric Gastroenterology, Bristol Royal Hospital for Children, Paul O'Gorman Building, Upper Maudlin Street, Bristol BS2 8BJ, UK.Department of Paediatric Gastroenterology, Bristol Royal Hospital for Children, Paul O'Gorman Building, Upper Maudlin Street, Bristol BS2 8BJ, UK.Department of Paediatric Gastroenterology, Bristol Royal Hospital for Children, Paul O'Gorman Building, Upper Maudlin Street, Bristol BS2 8BJ, UK.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

26101002

Citation

Paul, Siba Prosad, et al. "Applicability of the New ESPGHAN Guidelines for Diagnosing Coeliac Disease in Children From Resource Limited Countries." Journal of the College of Physicians and Surgeons--Pakistan : JCPSP, vol. 25, no. 6, 2015, pp. 455-7.
Paul SP, Mazhar H, Spray CH. Applicability of the New ESPGHAN Guidelines for Diagnosing Coeliac Disease in Children from Resource Limited Countries. J Coll Physicians Surg Pak. 2015;25(6):455-7.
Paul, S. P., Mazhar, H., & Spray, C. H. (2015). Applicability of the New ESPGHAN Guidelines for Diagnosing Coeliac Disease in Children from Resource Limited Countries. Journal of the College of Physicians and Surgeons--Pakistan : JCPSP, 25(6), pp. 455-7. doi:06.2015/JCPSP.455457.
Paul SP, Mazhar H, Spray CH. Applicability of the New ESPGHAN Guidelines for Diagnosing Coeliac Disease in Children From Resource Limited Countries. J Coll Physicians Surg Pak. 2015;25(6):455-7. PubMed PMID: 26101002.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Applicability of the New ESPGHAN Guidelines for Diagnosing Coeliac Disease in Children from Resource Limited Countries. AU - Paul,Siba Prosad, AU - Mazhar,Huma, AU - Spray,Christine Helen, PY - 2014/10/04/received PY - 2015/03/30/accepted PY - 2015/6/24/entrez PY - 2015/6/24/pubmed PY - 2016/8/10/medline SP - 455 EP - 7 JF - Journal of the College of Physicians and Surgeons--Pakistan : JCPSP JO - J Coll Physicians Surg Pak VL - 25 IS - 6 N2 - Coeliac Disease (CD) is an immune-mediated systemic disorder elicited by the ingestion of gluten. Small-bowel biopsies and histology has been the gold standard for diagnosing CD. The modified ESPGHAN guidelines recommend that in symptomatic children with anti-tissue-Transglutaminase (tTG) titre of > 10 times Upper-Limit-of-Normal (ULN), diagnosis of CD can be made without small-bowel biopsies. However, positive HLA-DQ2/DQ8 serotype and anti-Endomysial Antibodies (EMA) are necessary. Studies from resource-limited countries have demonstrated applicability of the ESPGHAN guidelines for serological diagnosis of CD. CD should not be diagnosed on the basis of a single high tTG-titre. Small-bowel biopsies are necessary for diagnosing CD in asymptomatic children and those with tTG-titre < 10 x ULN. Management of CD needs lifelong gluten free diet. SN - 1681-7168 UR - https://www.unboundmedicine.com/medline/citation/26101002/Applicability_of_the_New_ESPGHAN_Guidelines_for_Diagnosing_Coeliac_Disease_in_Children_from_Resource_Limited_Countries_ L2 - https://medlineplus.gov/celiacdisease.html DB - PRIME DP - Unbound Medicine ER -