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Tetrahydrocurcumin exerts protective effect on vincristine induced neuropathy: Behavioral, biochemical, neurophysiological and histological evidence.
Chem Biol Interact. 2015 Aug 05; 238:118-28.CB

Abstract

Hyperalgesia, allodynia, delayed motor nerve conduction velocity, oxidative stress and axonal damage are signs and symptoms of chemotherapy induced peripheral neuropathy (CIPN). Present treatment/preventive strategies of CIPN are futile and the neuropathy may even lead to discontinuation of chemotherapy. In this study, we evaluated the protective effect of tetrahydrocurcumin (THC) 40 and 80mg/kg in experimental vincristine induced neuropathy in rats. Hyperalgesia was assessed by hot plate (thermal), Randall-Selitto (mechanical) test, allodynia was assessed by cold plate (thermal) test, functional loss was measured by sciatic function index, nociception was evaluated by formalin test. Neurophysiological recordings were carried out to assess motor nerve conduction velocity. Total calcium levels, oxidative stress and TNF-α was measured in sciatic nerve tissue homogenate to assess neuropathy. Histopathological changes was observed on sciatic nerve to assess the protective effect of THC against the vincristine. Pregabalin was used as a standard in this study. Rats administered with THC at 80mg/kg significantly attenuated the vincristine induced neuropathic pain manifestations which may be due to its multiple actions including anti-nociceptive, anti-inflammatory, neuroprotective, calcium inhibitory and antioxidant effect. This study delineates that THC can be a promising candidate for the prevention of CIPN by chemotherapeutic agents.

Authors+Show Affiliations

Department of Pharmacology, PSG College of Pharmacy, Coimbatore 641004, Tamil Nadu, India.Department of Pharmacology, PSG College of Pharmacy, Coimbatore 641004, Tamil Nadu, India.Department of Pharmacology, PSG College of Pharmacy, Coimbatore 641004, Tamil Nadu, India. Electronic address: ubbalaji@gmail.com.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

26102012

Citation

Greeshma, N, et al. "Tetrahydrocurcumin Exerts Protective Effect On Vincristine Induced Neuropathy: Behavioral, Biochemical, Neurophysiological and Histological Evidence." Chemico-biological Interactions, vol. 238, 2015, pp. 118-28.
Greeshma N, Prasanth KG, Balaji B. Tetrahydrocurcumin exerts protective effect on vincristine induced neuropathy: Behavioral, biochemical, neurophysiological and histological evidence. Chem Biol Interact. 2015;238:118-28.
Greeshma, N., Prasanth, K. G., & Balaji, B. (2015). Tetrahydrocurcumin exerts protective effect on vincristine induced neuropathy: Behavioral, biochemical, neurophysiological and histological evidence. Chemico-biological Interactions, 238, 118-28. https://doi.org/10.1016/j.cbi.2015.06.025
Greeshma N, Prasanth KG, Balaji B. Tetrahydrocurcumin Exerts Protective Effect On Vincristine Induced Neuropathy: Behavioral, Biochemical, Neurophysiological and Histological Evidence. Chem Biol Interact. 2015 Aug 5;238:118-28. PubMed PMID: 26102012.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Tetrahydrocurcumin exerts protective effect on vincristine induced neuropathy: Behavioral, biochemical, neurophysiological and histological evidence. AU - Greeshma,N, AU - Prasanth,K G, AU - Balaji,Bhaskar, Y1 - 2015/06/20/ PY - 2015/01/31/received PY - 2015/05/21/revised PY - 2015/06/18/accepted PY - 2015/6/24/entrez PY - 2015/6/24/pubmed PY - 2015/10/21/medline KW - Allodynia KW - Anti-nociceptive KW - Hyperalgesia KW - Nerve conduction velocity KW - Pain KW - Sciatic nerve SP - 118 EP - 28 JF - Chemico-biological interactions JO - Chem Biol Interact VL - 238 N2 - Hyperalgesia, allodynia, delayed motor nerve conduction velocity, oxidative stress and axonal damage are signs and symptoms of chemotherapy induced peripheral neuropathy (CIPN). Present treatment/preventive strategies of CIPN are futile and the neuropathy may even lead to discontinuation of chemotherapy. In this study, we evaluated the protective effect of tetrahydrocurcumin (THC) 40 and 80mg/kg in experimental vincristine induced neuropathy in rats. Hyperalgesia was assessed by hot plate (thermal), Randall-Selitto (mechanical) test, allodynia was assessed by cold plate (thermal) test, functional loss was measured by sciatic function index, nociception was evaluated by formalin test. Neurophysiological recordings were carried out to assess motor nerve conduction velocity. Total calcium levels, oxidative stress and TNF-α was measured in sciatic nerve tissue homogenate to assess neuropathy. Histopathological changes was observed on sciatic nerve to assess the protective effect of THC against the vincristine. Pregabalin was used as a standard in this study. Rats administered with THC at 80mg/kg significantly attenuated the vincristine induced neuropathic pain manifestations which may be due to its multiple actions including anti-nociceptive, anti-inflammatory, neuroprotective, calcium inhibitory and antioxidant effect. This study delineates that THC can be a promising candidate for the prevention of CIPN by chemotherapeutic agents. SN - 1872-7786 UR - https://www.unboundmedicine.com/medline/citation/26102012/Tetrahydrocurcumin_exerts_protective_effect_on_vincristine_induced_neuropathy:_Behavioral_biochemical_neurophysiological_and_histological_evidence_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0009-2797(15)00256-2 DB - PRIME DP - Unbound Medicine ER -