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Forensic electrochemistry: indirect electrochemical sensing of the components of the new psychoactive substance "Synthacaine".
Analyst. 2015 Aug 21; 140(16):5536-45.A

Abstract

"Synthacaine" is a New Psychoactive Substance which is, due to its inherent psychoactive properties, reported to imitate the effects of cocaine and is therefore consequently branded as "legal cocaine". The only analytical approach reported to date for the sensing of "Synthacaine" is mass spectrometry. In this paper, we explore and evaluate a range of potential analytical techniques for its quantification and potential use in the field screening "Synthacaine" using Raman spectroscopy, presumptive (colour) testing, High Performance Liquid Chromatography (HPLC) and electrochemistry. HPLC analysis of street samples reveals that "Synthacaine" comprises a mixture of methiopropamine (MPA) and 2-aminoindane (2-AI). Raman spectroscopy and presumptive (colour) tests, the Marquis, Mandelin, Simon's and Robadope test, are evaluated towards a potential in-the-field screening approach but are found to not be able to discriminate between the two when they are both present in the same sample, as is the case in the real street samples. We report for the first time a novel indirect electrochemical protocol for the sensing of MPA and 2-AI which is independently validated in street samples with HPLC. This novel electrochemical approach based upon one-shot disposable cost effective screen-printed graphite macroelectrodes holds potential for in-the-field screening for "Synthacaine".

Authors+Show Affiliations

Faculdade de Engenharia de Ilha Solteira UNESP - Universidade Estadual Paulista, Departamento de Física e Química, Av. Brasil Centro, 56 - CEP 15385-000, Ilha Solteira, SP, Brazil.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

26102088

Citation

Cumba, Loanda R., et al. "Forensic Electrochemistry: Indirect Electrochemical Sensing of the Components of the New Psychoactive Substance "Synthacaine"." The Analyst, vol. 140, no. 16, 2015, pp. 5536-45.
Cumba LR, Kolliopoulos AV, Smith JP, et al. Forensic electrochemistry: indirect electrochemical sensing of the components of the new psychoactive substance "Synthacaine". Analyst. 2015;140(16):5536-45.
Cumba, L. R., Kolliopoulos, A. V., Smith, J. P., Thompson, P. D., Evans, P. R., Sutcliffe, O. B., do Carmo, D. R., & Banks, C. E. (2015). Forensic electrochemistry: indirect electrochemical sensing of the components of the new psychoactive substance "Synthacaine". The Analyst, 140(16), 5536-45. https://doi.org/10.1039/c5an00858a
Cumba LR, et al. Forensic Electrochemistry: Indirect Electrochemical Sensing of the Components of the New Psychoactive Substance "Synthacaine". Analyst. 2015 Aug 21;140(16):5536-45. PubMed PMID: 26102088.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Forensic electrochemistry: indirect electrochemical sensing of the components of the new psychoactive substance "Synthacaine". AU - Cumba,Loanda R, AU - Kolliopoulos,Athanasios V, AU - Smith,Jamie P, AU - Thompson,Paul D, AU - Evans,Peter R, AU - Sutcliffe,Oliver B, AU - do Carmo,Devaney R, AU - Banks,Craig E, PY - 2015/6/24/entrez PY - 2015/6/24/pubmed PY - 2016/3/18/medline SP - 5536 EP - 45 JF - The Analyst JO - Analyst VL - 140 IS - 16 N2 - "Synthacaine" is a New Psychoactive Substance which is, due to its inherent psychoactive properties, reported to imitate the effects of cocaine and is therefore consequently branded as "legal cocaine". The only analytical approach reported to date for the sensing of "Synthacaine" is mass spectrometry. In this paper, we explore and evaluate a range of potential analytical techniques for its quantification and potential use in the field screening "Synthacaine" using Raman spectroscopy, presumptive (colour) testing, High Performance Liquid Chromatography (HPLC) and electrochemistry. HPLC analysis of street samples reveals that "Synthacaine" comprises a mixture of methiopropamine (MPA) and 2-aminoindane (2-AI). Raman spectroscopy and presumptive (colour) tests, the Marquis, Mandelin, Simon's and Robadope test, are evaluated towards a potential in-the-field screening approach but are found to not be able to discriminate between the two when they are both present in the same sample, as is the case in the real street samples. We report for the first time a novel indirect electrochemical protocol for the sensing of MPA and 2-AI which is independently validated in street samples with HPLC. This novel electrochemical approach based upon one-shot disposable cost effective screen-printed graphite macroelectrodes holds potential for in-the-field screening for "Synthacaine". SN - 1364-5528 UR - https://www.unboundmedicine.com/medline/citation/26102088/Forensic_electrochemistry:_indirect_electrochemical_sensing_of_the_components_of_the_new_psychoactive_substance_"Synthacaine"_ L2 - https://doi.org/10.1039/c5an00858a DB - PRIME DP - Unbound Medicine ER -