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Food and food additives in severe atopic dermatitis.
Allergy. 1989 Nov; 44(8):588-94.A

Abstract

In this study the role of food additives, tyramine and acetylsalicylic acid, was investigated by double-blind placebo-controlled challenges (DBPCC) in 25 children with severe atopic dermatitis (AD). All children challenged with foods (n = 24), except one, showed one or more positive reactions to the DBPCC with foods. Positive reactions presented as different combinations of flares of skin symptoms, intestinal symptoms and respiratory symptoms. Seventeen children (70.8%) showed a positive challenge to egg, 12 to wheat (50%), eight to milk (33.3%) and eight to soya (33.3%). Six children underwent DBPCC with food additives, tyramine and acetylsalicylic acid. All were found to demonstrate positive skin and/or intestinal reactions to at least one of the food additives. Two children reacted to tartrazine, three to sodium benzoate, two to sodium glutamate, two to sodium metabisulfite, four to acetylsalicylic acid and one to tyramine. It is concluded that some foods, food additives, tyramine and acetylsalicylic acid, can cause positive DBPCC in children with severe AD.

Authors+Show Affiliations

Department of Paediatrics, University of Antwerp, Belgium.No affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Controlled Clinical Trial
Journal Article
Randomized Controlled Trial

Language

eng

PubMed ID

2610332

Citation

Van Bever, H P., et al. "Food and Food Additives in Severe Atopic Dermatitis." Allergy, vol. 44, no. 8, 1989, pp. 588-94.
Van Bever HP, Docx M, Stevens WJ. Food and food additives in severe atopic dermatitis. Allergy. 1989;44(8):588-94.
Van Bever, H. P., Docx, M., & Stevens, W. J. (1989). Food and food additives in severe atopic dermatitis. Allergy, 44(8), 588-94.
Van Bever HP, Docx M, Stevens WJ. Food and Food Additives in Severe Atopic Dermatitis. Allergy. 1989;44(8):588-94. PubMed PMID: 2610332.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Food and food additives in severe atopic dermatitis. AU - Van Bever,H P, AU - Docx,M, AU - Stevens,W J, PY - 1989/11/1/pubmed PY - 1989/11/1/medline PY - 1989/11/1/entrez SP - 588 EP - 94 JF - Allergy JO - Allergy VL - 44 IS - 8 N2 - In this study the role of food additives, tyramine and acetylsalicylic acid, was investigated by double-blind placebo-controlled challenges (DBPCC) in 25 children with severe atopic dermatitis (AD). All children challenged with foods (n = 24), except one, showed one or more positive reactions to the DBPCC with foods. Positive reactions presented as different combinations of flares of skin symptoms, intestinal symptoms and respiratory symptoms. Seventeen children (70.8%) showed a positive challenge to egg, 12 to wheat (50%), eight to milk (33.3%) and eight to soya (33.3%). Six children underwent DBPCC with food additives, tyramine and acetylsalicylic acid. All were found to demonstrate positive skin and/or intestinal reactions to at least one of the food additives. Two children reacted to tartrazine, three to sodium benzoate, two to sodium glutamate, two to sodium metabisulfite, four to acetylsalicylic acid and one to tyramine. It is concluded that some foods, food additives, tyramine and acetylsalicylic acid, can cause positive DBPCC in children with severe AD. SN - 0105-4538 UR - https://www.unboundmedicine.com/medline/citation/2610332/Food_and_food_additives_in_severe_atopic_dermatitis_ L2 - https://onlinelibrary.wiley.com/resolve/openurl?genre=article&sid=nlm:pubmed&issn=0105-4538&date=1989&volume=44&issue=8&spage=588 DB - PRIME DP - Unbound Medicine ER -