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The effect of prenatal exposure to phthalates on food allergy and early eczema in inner-city children.
Allergy Asthma Proc. 2015 Jul-Aug; 36(4):72-8.AA

Abstract

BACKGROUND AND OBJECTIVE

We hypothesized that maternal prenatal and children urine metabolite concentration of phthalates would be associated with food allergy and early eczema among inner-city children. The study was based on data from the Polish Mother and Child Cohort.

METHODS

Prenatal and postnatal exposure to the following phthalates: diethyl phthalate, diisobutyl phthalate, di-n-butyl phthalate, butyl-benzyl phthalate, di(2-ethylhexyl) phthalate, diisononyl phthalate, and di-n-octyl phthalate were determined by measuring phthalate metabolites in the urine collected from the mothers during the third trimester of pregnancy and from their children at age 2 years. Pre- and postnatal observations limited the response rate and final sample size; data from 147 participants were included in the analysis. Children's health status was assessed at 24 months of age by using a questionnaire administered to the mothers. We studied associations between the urine level of phthalates and the presence of food allergy and atopic dermatitis in logistic regression analysis. All associations were adjusted for independent risk factors of dependent variables. Associations with atopic dermatitis were adjusted for the effect of atopy in the family, the father's education, frequency of house cleaning, and breastfeeding; associations with food allergy were adjusted for the presence of pets at home during pregnancy and breastfeeding.

RESULTS

The prevalence of the outcomes were as follows: atopic dermatitis, 12.2%, and food allergy, 48.9%. We showed that higher urine concentrations of monobenzyl phthalate in mothers during pregnancy increased the risk of food allergy in children during the first 2 years of life (odds ratio 4.17 [95% confidence interval, 1.17-17.89]). There were no associations with children's urine and allergic symptoms.

CONCLUSIONS

Results of our study indicated awareness of environmental factors that may affect children's health because the phthalates were shown to be risk factors for food allergy in children.

Authors+Show Affiliations

Department of Pediatrics and Allergy, Medical University of Lodz, Copernicus Memorial Hospital in Lodz, Poland.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

26108074

Citation

Stelmach, Iwona, et al. "The Effect of Prenatal Exposure to Phthalates On Food Allergy and Early Eczema in Inner-city Children." Allergy and Asthma Proceedings, vol. 36, no. 4, 2015, pp. 72-8.
Stelmach I, Majak P, Jerzynska J, et al. The effect of prenatal exposure to phthalates on food allergy and early eczema in inner-city children. Allergy Asthma Proc. 2015;36(4):72-8.
Stelmach, I., Majak, P., Jerzynska, J., Podlecka, D., Stelmach, W., Polańska, K., Ligocka, D., & Hanke, W. (2015). The effect of prenatal exposure to phthalates on food allergy and early eczema in inner-city children. Allergy and Asthma Proceedings, 36(4), 72-8. https://doi.org/10.2500/aap.2015.36.3867
Stelmach I, et al. The Effect of Prenatal Exposure to Phthalates On Food Allergy and Early Eczema in Inner-city Children. Allergy Asthma Proc. 2015 Jul-Aug;36(4):72-8. PubMed PMID: 26108074.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The effect of prenatal exposure to phthalates on food allergy and early eczema in inner-city children. AU - Stelmach,Iwona, AU - Majak,Pawel, AU - Jerzynska,Joanna, AU - Podlecka,Daniela, AU - Stelmach,Wlodzimierz, AU - Polańska,Kinga, AU - Ligocka,Danuta, AU - Hanke,Wojciech, PY - 2015/6/25/entrez PY - 2015/6/25/pubmed PY - 2016/3/29/medline SP - 72 EP - 8 JF - Allergy and asthma proceedings JO - Allergy Asthma Proc VL - 36 IS - 4 N2 - BACKGROUND AND OBJECTIVE: We hypothesized that maternal prenatal and children urine metabolite concentration of phthalates would be associated with food allergy and early eczema among inner-city children. The study was based on data from the Polish Mother and Child Cohort. METHODS: Prenatal and postnatal exposure to the following phthalates: diethyl phthalate, diisobutyl phthalate, di-n-butyl phthalate, butyl-benzyl phthalate, di(2-ethylhexyl) phthalate, diisononyl phthalate, and di-n-octyl phthalate were determined by measuring phthalate metabolites in the urine collected from the mothers during the third trimester of pregnancy and from their children at age 2 years. Pre- and postnatal observations limited the response rate and final sample size; data from 147 participants were included in the analysis. Children's health status was assessed at 24 months of age by using a questionnaire administered to the mothers. We studied associations between the urine level of phthalates and the presence of food allergy and atopic dermatitis in logistic regression analysis. All associations were adjusted for independent risk factors of dependent variables. Associations with atopic dermatitis were adjusted for the effect of atopy in the family, the father's education, frequency of house cleaning, and breastfeeding; associations with food allergy were adjusted for the presence of pets at home during pregnancy and breastfeeding. RESULTS: The prevalence of the outcomes were as follows: atopic dermatitis, 12.2%, and food allergy, 48.9%. We showed that higher urine concentrations of monobenzyl phthalate in mothers during pregnancy increased the risk of food allergy in children during the first 2 years of life (odds ratio 4.17 [95% confidence interval, 1.17-17.89]). There were no associations with children's urine and allergic symptoms. CONCLUSIONS: Results of our study indicated awareness of environmental factors that may affect children's health because the phthalates were shown to be risk factors for food allergy in children. SN - 1539-6304 UR - https://www.unboundmedicine.com/medline/citation/26108074/The_effect_of_prenatal_exposure_to_phthalates_on_food_allergy_and_early_eczema_in_inner_city_children_ L2 - https://www.ingentaconnect.com/openurl?genre=article&issn=1539-6304&volume=36&issue=4&spage=72&aulast=Stelmach DB - PRIME DP - Unbound Medicine ER -