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Spinal Bone Texture Assessed by Trabecular Bone Score in Adolescent Girls With Anorexia Nervosa.
J Clin Endocrinol Metab. 2015 Sep; 100(9):3436-42.JC

Abstract

CONTEXT

Trabecular bone score (TBS) is a bone assessment tool that offers information beyond that afforded by dual-energy x-ray absorptiometry (DXA) bone mineral density (BMD) measurements. Adolescents with anorexia nervosa (AN) are known to exhibit compromised bone density and skeletal strength.

OBJECTIVES

This study aimed to determine TBS among adolescents with AN and evaluate the correlation with anthropometric, clinical and densitometric variables.

DESIGN

Areal BMD spinal measures were analyzed for TBS. Findings were compared with clinical (height, weight, body mass index [BMI], age, pubertal development, 25-hydroxyvitamin D) and self-reported data (illness duration, amenorrhea, exercise, fracture, family history of osteoporosis, and antidepressant use), and BMD measures by DXA and peripheral quantitative computed tomography (pQCT).

SETTING AND PARTICIPANTS

This was an urban adolescent program consisting of 57 females with AN, age 11-18 y.

INTERVENTIONS

Interventions included DXA (absolute BMD and Z-score), pQCT (volumetric BMD [vBMD] and stress-strain index [SSI]), laboratory evaluation, and questionnaire administration.

MAIN OUTCOME MEASURES

Main outcome measures included TBS, areal and vBMD, SSI, fracture history, disease duration.

RESULTS

The TBS of six participants (11%) showed degraded and 19 (33%) partially degraded microarchitecture. Spinal TBS was correlated (P < .05) with age, height, weight, BMI, pubertal stage, BMD, and body composition by DXA, and BMD and SSI by pQCT. TBS was not correlated with disease duration, fracture, vitamin D status, race, or ethnicity, and self-reported health data.

CONCLUSIONS

TBS showed evidence of degraded microarchitecture in over 40% of this study sample, and strongly correlated with anthropometric data and measures of BMD and skeletal strength. TBS is a novel tool that captures another dimension of bone health in adolescents with AN.

Authors+Show Affiliations

Division of Adolescent Medicine (A.A.D., J.M.O., C.M.G.), Hasbro Children's Hospital and Alpert Medical School of Brown University, Providence, Rhode Island 02903; Clinical Research Center (H.A.F.), Boston Children's Hospital, Boston, Massachusetts 02115; and Division of Endocrinology (G.G.), Women and Infants Hospital and Alpert Medical School of Brown University, Providence, Rhode Island 02903.Division of Adolescent Medicine (A.A.D., J.M.O., C.M.G.), Hasbro Children's Hospital and Alpert Medical School of Brown University, Providence, Rhode Island 02903; Clinical Research Center (H.A.F.), Boston Children's Hospital, Boston, Massachusetts 02115; and Division of Endocrinology (G.G.), Women and Infants Hospital and Alpert Medical School of Brown University, Providence, Rhode Island 02903.Division of Adolescent Medicine (A.A.D., J.M.O., C.M.G.), Hasbro Children's Hospital and Alpert Medical School of Brown University, Providence, Rhode Island 02903; Clinical Research Center (H.A.F.), Boston Children's Hospital, Boston, Massachusetts 02115; and Division of Endocrinology (G.G.), Women and Infants Hospital and Alpert Medical School of Brown University, Providence, Rhode Island 02903.Division of Adolescent Medicine (A.A.D., J.M.O., C.M.G.), Hasbro Children's Hospital and Alpert Medical School of Brown University, Providence, Rhode Island 02903; Clinical Research Center (H.A.F.), Boston Children's Hospital, Boston, Massachusetts 02115; and Division of Endocrinology (G.G.), Women and Infants Hospital and Alpert Medical School of Brown University, Providence, Rhode Island 02903.Division of Adolescent Medicine (A.A.D., J.M.O., C.M.G.), Hasbro Children's Hospital and Alpert Medical School of Brown University, Providence, Rhode Island 02903; Clinical Research Center (H.A.F.), Boston Children's Hospital, Boston, Massachusetts 02115; and Division of Endocrinology (G.G.), Women and Infants Hospital and Alpert Medical School of Brown University, Providence, Rhode Island 02903.

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

26108094

Citation

Donaldson, Abigail A., et al. "Spinal Bone Texture Assessed By Trabecular Bone Score in Adolescent Girls With Anorexia Nervosa." The Journal of Clinical Endocrinology and Metabolism, vol. 100, no. 9, 2015, pp. 3436-42.
Donaldson AA, Feldman HA, O'Donnell JM, et al. Spinal Bone Texture Assessed by Trabecular Bone Score in Adolescent Girls With Anorexia Nervosa. J Clin Endocrinol Metab. 2015;100(9):3436-42.
Donaldson, A. A., Feldman, H. A., O'Donnell, J. M., Gopalakrishnan, G., & Gordon, C. M. (2015). Spinal Bone Texture Assessed by Trabecular Bone Score in Adolescent Girls With Anorexia Nervosa. The Journal of Clinical Endocrinology and Metabolism, 100(9), 3436-42. https://doi.org/10.1210/jc.2015-2002
Donaldson AA, et al. Spinal Bone Texture Assessed By Trabecular Bone Score in Adolescent Girls With Anorexia Nervosa. J Clin Endocrinol Metab. 2015;100(9):3436-42. PubMed PMID: 26108094.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Spinal Bone Texture Assessed by Trabecular Bone Score in Adolescent Girls With Anorexia Nervosa. AU - Donaldson,Abigail A, AU - Feldman,Henry A, AU - O'Donnell,Jennifer M, AU - Gopalakrishnan,Geetha, AU - Gordon,Catherine M, Y1 - 2015/06/24/ PY - 2015/6/25/entrez PY - 2015/6/25/pubmed PY - 2015/12/15/medline SP - 3436 EP - 42 JF - The Journal of clinical endocrinology and metabolism JO - J Clin Endocrinol Metab VL - 100 IS - 9 N2 - CONTEXT: Trabecular bone score (TBS) is a bone assessment tool that offers information beyond that afforded by dual-energy x-ray absorptiometry (DXA) bone mineral density (BMD) measurements. Adolescents with anorexia nervosa (AN) are known to exhibit compromised bone density and skeletal strength. OBJECTIVES: This study aimed to determine TBS among adolescents with AN and evaluate the correlation with anthropometric, clinical and densitometric variables. DESIGN: Areal BMD spinal measures were analyzed for TBS. Findings were compared with clinical (height, weight, body mass index [BMI], age, pubertal development, 25-hydroxyvitamin D) and self-reported data (illness duration, amenorrhea, exercise, fracture, family history of osteoporosis, and antidepressant use), and BMD measures by DXA and peripheral quantitative computed tomography (pQCT). SETTING AND PARTICIPANTS: This was an urban adolescent program consisting of 57 females with AN, age 11-18 y. INTERVENTIONS: Interventions included DXA (absolute BMD and Z-score), pQCT (volumetric BMD [vBMD] and stress-strain index [SSI]), laboratory evaluation, and questionnaire administration. MAIN OUTCOME MEASURES: Main outcome measures included TBS, areal and vBMD, SSI, fracture history, disease duration. RESULTS: The TBS of six participants (11%) showed degraded and 19 (33%) partially degraded microarchitecture. Spinal TBS was correlated (P < .05) with age, height, weight, BMI, pubertal stage, BMD, and body composition by DXA, and BMD and SSI by pQCT. TBS was not correlated with disease duration, fracture, vitamin D status, race, or ethnicity, and self-reported health data. CONCLUSIONS: TBS showed evidence of degraded microarchitecture in over 40% of this study sample, and strongly correlated with anthropometric data and measures of BMD and skeletal strength. TBS is a novel tool that captures another dimension of bone health in adolescents with AN. SN - 1945-7197 UR - https://www.unboundmedicine.com/medline/citation/26108094/Spinal_Bone_Texture_Assessed_by_Trabecular_Bone_Score_in_Adolescent_Girls_With_Anorexia_Nervosa_ L2 - https://academic.oup.com/jcem/article-lookup/doi/10.1210/jc.2015-2002 DB - PRIME DP - Unbound Medicine ER -