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Clinicopathological Analysis of Ocular Adnexal Extranodal Marginal Zone B-Cell Lymphoma with IgG4-Positive Cells.
PLoS One. 2015; 10(6):e0131458.Plos

Abstract

This study aims to analyze clinical and pathological characteristics of ocular adnexal extranodal marginal zone B-cell lymphoma (EMZL) accompanying IgG4-positive cells. Fifty patients with a diagnosis of primary non-conjunctival ocular adnexal EMZL were enrolled in this study. The number of IgG4-positive cells and the ratio of IgG/IgG4 were evaluated by immunohistochemistry in the biopsy specimens. The patients were divided into two groups based on the absolute number and the ratio of IgG4-positive cells (IgG4-posivite vs IgG4-negative groups). The demographic data, clinical staging at diagnosis, histopathological characteristics, and response to initial treatment were comparatively analyzed between the 2 groups. Five (10%) of 50 patients were defined as IgG4-positive group, and all the cases showed characteristic histological features such as extensive plasma cell infiltration and dense fibrosis. Most of these patients (4 of 5 patients) had lymphoma of the lacrimal gland. The patients from the IgG4-positive group showed a lower response rate to initial treatment (87.5 vs 33%, p = 0.03) than IgG4-negative group with a median follow-up period of 38 months. A part of the ocular adnexal EMZLs were accompanied with IgG4-positive cells. Significantly, most IgG4-positive ocular adnexal EMZLs occurred in the lacrimal gland, and can be related with a more frequent treatment failure.

Authors+Show Affiliations

Department of Ophthalmology, Hallym University Sacred Heart Hospital, Anyang, Korea.Department of Ophthalmology, Seoul National University Bundang Hospital, Seungnam, Korea.Department of Pathology, Seoul National University Bundang Hospital, Seungnam, Korea.Department of Ophthalmology, Seoul National University Hospital, Seoul, Korea.Department of Pathology, Seoul National University Hospital, Seoul, Korea.Department of Ophthalmology, Seoul National University Boramae Hospital, Seoul, Korea.Department of Pathology, Seoul National University Boramae Hospital, Seoul, Korea.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

26111022

Citation

Lee, Min Joung, et al. "Clinicopathological Analysis of Ocular Adnexal Extranodal Marginal Zone B-Cell Lymphoma With IgG4-Positive Cells." PloS One, vol. 10, no. 6, 2015, pp. e0131458.
Lee MJ, Kim N, Choe JY, et al. Clinicopathological Analysis of Ocular Adnexal Extranodal Marginal Zone B-Cell Lymphoma with IgG4-Positive Cells. PLoS ONE. 2015;10(6):e0131458.
Lee, M. J., Kim, N., Choe, J. Y., Khwarg, S. I., Jeon, Y. K., Choung, H. K., & Kim, J. E. (2015). Clinicopathological Analysis of Ocular Adnexal Extranodal Marginal Zone B-Cell Lymphoma with IgG4-Positive Cells. PloS One, 10(6), e0131458. https://doi.org/10.1371/journal.pone.0131458
Lee MJ, et al. Clinicopathological Analysis of Ocular Adnexal Extranodal Marginal Zone B-Cell Lymphoma With IgG4-Positive Cells. PLoS ONE. 2015;10(6):e0131458. PubMed PMID: 26111022.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Clinicopathological Analysis of Ocular Adnexal Extranodal Marginal Zone B-Cell Lymphoma with IgG4-Positive Cells. AU - Lee,Min Joung, AU - Kim,Namju, AU - Choe,Ji-Young, AU - Khwarg,Sang In, AU - Jeon,Yoon Kyung, AU - Choung,Ho-Kyung, AU - Kim,Ji Eun, Y1 - 2015/06/25/ PY - 2014/11/16/received PY - 2015/06/02/accepted PY - 2015/6/26/entrez PY - 2015/6/26/pubmed PY - 2016/5/11/medline SP - e0131458 EP - e0131458 JF - PloS one JO - PLoS ONE VL - 10 IS - 6 N2 - This study aims to analyze clinical and pathological characteristics of ocular adnexal extranodal marginal zone B-cell lymphoma (EMZL) accompanying IgG4-positive cells. Fifty patients with a diagnosis of primary non-conjunctival ocular adnexal EMZL were enrolled in this study. The number of IgG4-positive cells and the ratio of IgG/IgG4 were evaluated by immunohistochemistry in the biopsy specimens. The patients were divided into two groups based on the absolute number and the ratio of IgG4-positive cells (IgG4-posivite vs IgG4-negative groups). The demographic data, clinical staging at diagnosis, histopathological characteristics, and response to initial treatment were comparatively analyzed between the 2 groups. Five (10%) of 50 patients were defined as IgG4-positive group, and all the cases showed characteristic histological features such as extensive plasma cell infiltration and dense fibrosis. Most of these patients (4 of 5 patients) had lymphoma of the lacrimal gland. The patients from the IgG4-positive group showed a lower response rate to initial treatment (87.5 vs 33%, p = 0.03) than IgG4-negative group with a median follow-up period of 38 months. A part of the ocular adnexal EMZLs were accompanied with IgG4-positive cells. Significantly, most IgG4-positive ocular adnexal EMZLs occurred in the lacrimal gland, and can be related with a more frequent treatment failure. SN - 1932-6203 UR - https://www.unboundmedicine.com/medline/citation/26111022/Clinicopathological_Analysis_of_Ocular_Adnexal_Extranodal_Marginal_Zone_B_Cell_Lymphoma_with_IgG4_Positive_Cells_ L2 - http://dx.plos.org/10.1371/journal.pone.0131458 DB - PRIME DP - Unbound Medicine ER -