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Type 2 diabetes mellitus and risk of gallbladder cancer: a systematic review and meta-analysis of observational studies.
Diabetes Metab Res Rev 2016; 32(1):63-72DM

Abstract

AIMS

Increasing evidence suggests that a history of type 2 diabetes mellitus (type 2 DM) may be involved in the development of various sites of cancer. However, the association with risk of gallbladder cancer remains unclear.

METHODS

We identified studies by a literature search of MEDLINE and EMBASE through 31 August 2014 and by searching the reference lists of pertinent articles. All data were independently extracted by two investigators using a standardized data abstraction tool. Summary relative risks (SRRs) with 95% confidence intervals (CIs) were calculated with a random effects model.

RESULTS

A total of 20 studies (eight case-control studies and 12 cohort studies) were included in this meta-analysis. Analysis of these 20 studies found that compared with non-diabetic individuals, diabetic individuals had an increased risk of gallbladder cancer (SRR = 1.56, 95% CI: 1.36-1.79). There was evidence of moderate heterogeneity among these studies (p = 0.010 and I(2) = 43.5%). This increased risk relationship is independent of smoking, body mass index and a history of gallstones. However, whether or not controlled for, alcohol use may be one of the potential confounders that significantly affect the association between type 2 DM and the risk of gallbladder cancer. Diabetic women and men had a similarly increased risk of gallbladder cancer associated with type 2 DM.

CONCLUSIONS

These findings of this systematic review indicate that compared with non-diabetic individuals, both men and women with type 2 DM had an increased risk of gallbladder cancer. Copyright © 2015 John Wiley & Sons, Ltd.

Authors+Show Affiliations

Department of General Surgery, Xinhua Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China.Department of Gastroenterology, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.Department of Gastroenterology, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.Department of Gastroenterology, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.Department of Gastroenterology, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.Department of Gastroenterology, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.Department of Gastroenterology, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.

Pub Type(s)

Journal Article
Meta-Analysis
Review
Systematic Review

Language

eng

PubMed ID

26111736

Citation

Gu, Jun, et al. "Type 2 Diabetes Mellitus and Risk of Gallbladder Cancer: a Systematic Review and Meta-analysis of Observational Studies." Diabetes/metabolism Research and Reviews, vol. 32, no. 1, 2016, pp. 63-72.
Gu J, Yan S, Wang B, et al. Type 2 diabetes mellitus and risk of gallbladder cancer: a systematic review and meta-analysis of observational studies. Diabetes Metab Res Rev. 2016;32(1):63-72.
Gu, J., Yan, S., Wang, B., Shen, F., Cao, H., Fan, J., & Wang, Y. (2016). Type 2 diabetes mellitus and risk of gallbladder cancer: a systematic review and meta-analysis of observational studies. Diabetes/metabolism Research and Reviews, 32(1), pp. 63-72. doi:10.1002/dmrr.2671.
Gu J, et al. Type 2 Diabetes Mellitus and Risk of Gallbladder Cancer: a Systematic Review and Meta-analysis of Observational Studies. Diabetes Metab Res Rev. 2016;32(1):63-72. PubMed PMID: 26111736.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Type 2 diabetes mellitus and risk of gallbladder cancer: a systematic review and meta-analysis of observational studies. AU - Gu,Jun, AU - Yan,Shiyan, AU - Wang,Baochan, AU - Shen,Feng, AU - Cao,Haixia, AU - Fan,Jiangao, AU - Wang,Yuqin, Y1 - 2015/08/18/ PY - 2014/11/30/received PY - 2015/05/05/revised PY - 2015/06/12/accepted PY - 2015/6/27/entrez PY - 2015/6/27/pubmed PY - 2016/10/14/medline KW - diabetes mellitus KW - gallbladder cancer KW - meta-analysis KW - observational study KW - relative risk SP - 63 EP - 72 JF - Diabetes/metabolism research and reviews JO - Diabetes Metab. Res. Rev. VL - 32 IS - 1 N2 - AIMS: Increasing evidence suggests that a history of type 2 diabetes mellitus (type 2 DM) may be involved in the development of various sites of cancer. However, the association with risk of gallbladder cancer remains unclear. METHODS: We identified studies by a literature search of MEDLINE and EMBASE through 31 August 2014 and by searching the reference lists of pertinent articles. All data were independently extracted by two investigators using a standardized data abstraction tool. Summary relative risks (SRRs) with 95% confidence intervals (CIs) were calculated with a random effects model. RESULTS: A total of 20 studies (eight case-control studies and 12 cohort studies) were included in this meta-analysis. Analysis of these 20 studies found that compared with non-diabetic individuals, diabetic individuals had an increased risk of gallbladder cancer (SRR = 1.56, 95% CI: 1.36-1.79). There was evidence of moderate heterogeneity among these studies (p = 0.010 and I(2) = 43.5%). This increased risk relationship is independent of smoking, body mass index and a history of gallstones. However, whether or not controlled for, alcohol use may be one of the potential confounders that significantly affect the association between type 2 DM and the risk of gallbladder cancer. Diabetic women and men had a similarly increased risk of gallbladder cancer associated with type 2 DM. CONCLUSIONS: These findings of this systematic review indicate that compared with non-diabetic individuals, both men and women with type 2 DM had an increased risk of gallbladder cancer. Copyright © 2015 John Wiley & Sons, Ltd. SN - 1520-7560 UR - https://www.unboundmedicine.com/medline/citation/26111736/Type_2_diabetes_mellitus_and_risk_of_gallbladder_cancer:_a_systematic_review_and_meta_analysis_of_observational_studies_ L2 - https://doi.org/10.1002/dmrr.2671 DB - PRIME DP - Unbound Medicine ER -