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Coxsackievirus A6: a new emerging pathogen causing hand, foot and mouth disease outbreaks worldwide.
Expert Rev Anti Infect Ther. 2015; 13(9):1061-71.ER

Abstract

Enterovirus 71 (EV71) and coxsackievirus A16 (CA16) are the predominant pathogens causing outbreaks of hand, foot and mouth disease (HFMD) worldwide. Other human enterovirus A (HEV-A) serotypes tend to cause only sporadic HFMD cases. However, since a HFMD caused by coxsackievirus A6 broke out in Finland in 2008, CA6 has been identified as the responsible pathogen for a series of HFMD outbreaks in Europe, North America and Asia. Because of the severity of the clinical manifestations and the underestimated public health burden, the epidemic of CA6-associated HFMD presents a new challenge to the control of HFMD. This article reviewed the epidemic characteristics, molecular epidemiology, clinical features and laboratory diagnosis of CA6 infection. The genetic evolution of CA6 strains associated with HFMD was also analyzed. It indicated that the development of a multivalent vaccine combining EV71, CA16 and CA6 is an urgent necessity to control HFMD.

Authors+Show Affiliations

National Institutes for Food and Drug Control, Beijing 100050, China.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

26112307

Citation

Bian, Lianlian, et al. "Coxsackievirus A6: a New Emerging Pathogen Causing Hand, Foot and Mouth Disease Outbreaks Worldwide." Expert Review of Anti-infective Therapy, vol. 13, no. 9, 2015, pp. 1061-71.
Bian L, Wang Y, Yao X, et al. Coxsackievirus A6: a new emerging pathogen causing hand, foot and mouth disease outbreaks worldwide. Expert Rev Anti Infect Ther. 2015;13(9):1061-71.
Bian, L., Wang, Y., Yao, X., Mao, Q., Xu, M., & Liang, Z. (2015). Coxsackievirus A6: a new emerging pathogen causing hand, foot and mouth disease outbreaks worldwide. Expert Review of Anti-infective Therapy, 13(9), 1061-71. https://doi.org/10.1586/14787210.2015.1058156
Bian L, et al. Coxsackievirus A6: a New Emerging Pathogen Causing Hand, Foot and Mouth Disease Outbreaks Worldwide. Expert Rev Anti Infect Ther. 2015;13(9):1061-71. PubMed PMID: 26112307.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Coxsackievirus A6: a new emerging pathogen causing hand, foot and mouth disease outbreaks worldwide. AU - Bian,Lianlian, AU - Wang,Yiping, AU - Yao,Xin, AU - Mao,Qunying, AU - Xu,Miao, AU - Liang,Zhenglun, Y1 - 2015/06/25/ PY - 2015/6/27/entrez PY - 2015/6/27/pubmed PY - 2016/5/14/medline KW - coxsackievirus A16 KW - coxsackievirus A6 KW - enterovirus 71 KW - hand, foot and mouth disease KW - vaccine SP - 1061 EP - 71 JF - Expert review of anti-infective therapy JO - Expert Rev Anti Infect Ther VL - 13 IS - 9 N2 - Enterovirus 71 (EV71) and coxsackievirus A16 (CA16) are the predominant pathogens causing outbreaks of hand, foot and mouth disease (HFMD) worldwide. Other human enterovirus A (HEV-A) serotypes tend to cause only sporadic HFMD cases. However, since a HFMD caused by coxsackievirus A6 broke out in Finland in 2008, CA6 has been identified as the responsible pathogen for a series of HFMD outbreaks in Europe, North America and Asia. Because of the severity of the clinical manifestations and the underestimated public health burden, the epidemic of CA6-associated HFMD presents a new challenge to the control of HFMD. This article reviewed the epidemic characteristics, molecular epidemiology, clinical features and laboratory diagnosis of CA6 infection. The genetic evolution of CA6 strains associated with HFMD was also analyzed. It indicated that the development of a multivalent vaccine combining EV71, CA16 and CA6 is an urgent necessity to control HFMD. SN - 1744-8336 UR - https://www.unboundmedicine.com/medline/citation/26112307/Coxsackievirus_A6:_a_new_emerging_pathogen_causing_hand_foot_and_mouth_disease_outbreaks_worldwide_ L2 - http://www.tandfonline.com/doi/full/10.1586/14787210.2015.1058156 DB - PRIME DP - Unbound Medicine ER -