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Trend of Japanese encephalitis in Uttar Pradesh, India from 2011 to 2013.
Epidemiol Infect. 2016 Jan; 144(2):363-70.EI

Abstract

As indicated by the sporadic Japanese encephalitis (JE) cases reported from the districts of Uttar Pradesh (UP), India, the disease is endemic in the state despite the fact that a JE vaccination programme has been ongoing in the state since 2006. Hence, the present study was undertaken to study the annual trend of JE in UP during January 2011 to December 2013. CSF and/or serum samples collected from acute encephalitis syndrome (AES) cases were referred to the virology laboratory at King George's Medical University, Lucknow and were tested for anti-JEV IgM antibodies by JEV MAC-ELISA kit. The study reveals that 26·9%, 9·9% and 14·8% of AES cases were positive for anti-JEV IgM in the years 2011, 2012 and 2013, respectively. Of the total JE confirmed cases, 30% were adults. Males were more commonly affected than females. A distinct peak of JE was seen in the monsoon and post-monsoon season, although sporadic cases were also reported in other months. JE vaccination by district in UP is discussed. This study reports that the proportion of JE positives in AES cases is decreasing in UP although the number of AES cases has not decreased. The study also discusses the probable causes of this decrease, including JE vaccination and natural periodicity due to herd immunity.

Authors+Show Affiliations

Department of Microbiology,King George's Medical University,Lucknow,India.Department of Microbiology,King George's Medical University,Lucknow,India.Department of Microbiology,King George's Medical University,Lucknow,India.Department of Microbiology,King George's Medical University,Lucknow,India.Department of Paediatrics,King George's Medical University,Lucknow,India.Department of Neurology,King George's Medical University,Lucknow,India.Department of Microbiology,King George's Medical University,Lucknow,India.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

26112391

Citation

Jain, P, et al. "Trend of Japanese Encephalitis in Uttar Pradesh, India From 2011 to 2013." Epidemiology and Infection, vol. 144, no. 2, 2016, pp. 363-70.
Jain P, Singh AK, Khan DN, et al. Trend of Japanese encephalitis in Uttar Pradesh, India from 2011 to 2013. Epidemiol Infect. 2016;144(2):363-70.
Jain, P., Singh, A. K., Khan, D. N., Pandey, M., Kumar, R., Garg, R., & Jain, A. (2016). Trend of Japanese encephalitis in Uttar Pradesh, India from 2011 to 2013. Epidemiology and Infection, 144(2), 363-70. https://doi.org/10.1017/S0950268815000928
Jain P, et al. Trend of Japanese Encephalitis in Uttar Pradesh, India From 2011 to 2013. Epidemiol Infect. 2016;144(2):363-70. PubMed PMID: 26112391.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Trend of Japanese encephalitis in Uttar Pradesh, India from 2011 to 2013. AU - Jain,P, AU - Singh,A K, AU - Khan,D N, AU - Pandey,M, AU - Kumar,R, AU - Garg,R, AU - Jain,A, Y1 - 2015/06/26/ PY - 2015/6/27/entrez PY - 2015/6/27/pubmed PY - 2016/3/26/medline KW - Epidemiology KW - general virology SP - 363 EP - 70 JF - Epidemiology and infection JO - Epidemiol Infect VL - 144 IS - 2 N2 - As indicated by the sporadic Japanese encephalitis (JE) cases reported from the districts of Uttar Pradesh (UP), India, the disease is endemic in the state despite the fact that a JE vaccination programme has been ongoing in the state since 2006. Hence, the present study was undertaken to study the annual trend of JE in UP during January 2011 to December 2013. CSF and/or serum samples collected from acute encephalitis syndrome (AES) cases were referred to the virology laboratory at King George's Medical University, Lucknow and were tested for anti-JEV IgM antibodies by JEV MAC-ELISA kit. The study reveals that 26·9%, 9·9% and 14·8% of AES cases were positive for anti-JEV IgM in the years 2011, 2012 and 2013, respectively. Of the total JE confirmed cases, 30% were adults. Males were more commonly affected than females. A distinct peak of JE was seen in the monsoon and post-monsoon season, although sporadic cases were also reported in other months. JE vaccination by district in UP is discussed. This study reports that the proportion of JE positives in AES cases is decreasing in UP although the number of AES cases has not decreased. The study also discusses the probable causes of this decrease, including JE vaccination and natural periodicity due to herd immunity. SN - 1469-4409 UR - https://www.unboundmedicine.com/medline/citation/26112391/Trend_of_Japanese_encephalitis_in_Uttar_Pradesh_India_from_2011_to_2013_ L2 - https://www.cambridge.org/core/product/identifier/S0950268815000928/type/journal_article DB - PRIME DP - Unbound Medicine ER -