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Validation of the Spanish version of the Clinical Assessment for Negative Symptoms (CAINS).
Schizophr Res 2015; 166(1-3):104-9SR

Abstract

Negative symptoms are a core feature of schizophrenia and their reliable and valid assessment is a prerequisite for developing effective therapeutic interventions. This study examined the psychometric properties and validity of the Spanish version of a new rating instrument, the Clinical Assessment Interview for Negative Symptoms (CAINS). Outpatients and inpatients (N=100) with DSM-IV schizophrenia were administered the translated CAINS, the Positive and Negative Syndrome Scale (PANSS), the Scale for the Assessment of Negative Symptoms (SANS), and the Calgary Depression Scale for Schizophrenia (CDSS). A subsample (N=46) was rated for Parkinsonism using the Extrapyramidal Symptoms Rating Scale (ESRS). The scale showed good inter-rater and intra-rater reliability. Both the CAINS overall and the subscales for motivation/pleasure (CAINS-Map) and expression (CAINS-Exp) scores correlated significantly with the SANS and PANSS negative symptom scale. Significant correlations with positive symptoms and general psychopathology were also found, but these reduced and mostly became insignificant when overall severity of illness was controlled for. Significant correlations with depression also disappeared when severity was controlled for. There was a trend-level correlation between the CAINS total score and Parkinsonism, which reflected an association with the CAINS-Exp subscale only. Factor analysis revealed a two-dimensional structure that explained the 67.44% of the variance. Overall, the Spanish version of the CAINS appears to be a valid tool for measuring negative symptoms in schizophrenia.

Authors+Show Affiliations

FIDMAG Germanes Hospitalàries Research Foundation, Barcelona, Spain; Benito Menni Complex Assistencial en Salut Mental, Sant Boi de Llobregat, Spain; Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Barcelona, Spain.; Programa de Doctorat. Universitat de Barcelona, Barcelona, Spain.Programa de Doctorat. Universitat de Barcelona, Barcelona, Spain; Barcelona Clinic Schizophrenia Unit, Neuroscience Institute, Hospital Clinic of Barcelona, Barcelona, Spain.FIDMAG Germanes Hospitalàries Research Foundation, Barcelona, Spain; Benito Menni Complex Assistencial en Salut Mental, Sant Boi de Llobregat, Spain; Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Barcelona, Spain.Barcelona Clinic Schizophrenia Unit, Neuroscience Institute, Hospital Clinic of Barcelona, Barcelona, Spain.Centro Neuropsiquiátrico Nuestra Señora del Carmen. Hermanas Hospitalarias, Zaragoza, Spain.Centro Neuropsiquiátrico Nuestra Señora del Carmen. Hermanas Hospitalarias, Zaragoza, Spain.Centro Neuropsiquiátrico Nuestra Señora del Carmen. Hermanas Hospitalarias, Zaragoza, Spain.FIDMAG Germanes Hospitalàries Research Foundation, Barcelona, Spain; Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Barcelona, Spain.FIDMAG Germanes Hospitalàries Research Foundation, Barcelona, Spain; Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Barcelona, Spain.FIDMAG Germanes Hospitalàries Research Foundation, Barcelona, Spain; Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Barcelona, Spain.. Electronic address: ssarro@fidmag.com.Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Barcelona, Spain.; Programa de Doctorat. Universitat de Barcelona, Barcelona, Spain; Barcelona Clinic Schizophrenia Unit, Neuroscience Institute, Hospital Clinic of Barcelona, Barcelona, Spain; Department of Psychiatry and Clinical Psychobiology, University of Barcelona. Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Validation Studies

Language

eng

PubMed ID

26116328

Citation

Valiente-Gómez, Alicia, et al. "Validation of the Spanish Version of the Clinical Assessment for Negative Symptoms (CAINS)." Schizophrenia Research, vol. 166, no. 1-3, 2015, pp. 104-9.
Valiente-Gómez A, Mezquida G, Romaguera A, et al. Validation of the Spanish version of the Clinical Assessment for Negative Symptoms (CAINS). Schizophr Res. 2015;166(1-3):104-9.
Valiente-Gómez, A., Mezquida, G., Romaguera, A., Vilardebò, I., Andrés, H., Granados, B., ... Bernardo, M. (2015). Validation of the Spanish version of the Clinical Assessment for Negative Symptoms (CAINS). Schizophrenia Research, 166(1-3), pp. 104-9. doi:10.1016/j.schres.2015.06.006.
Valiente-Gómez A, et al. Validation of the Spanish Version of the Clinical Assessment for Negative Symptoms (CAINS). Schizophr Res. 2015;166(1-3):104-9. PubMed PMID: 26116328.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Validation of the Spanish version of the Clinical Assessment for Negative Symptoms (CAINS). AU - Valiente-Gómez,Alicia, AU - Mezquida,Gisela, AU - Romaguera,Anna, AU - Vilardebò,Irene, AU - Andrés,Helena, AU - Granados,Bianca, AU - Larrubia,Jesús, AU - Pomarol-Clotet,Edith, AU - McKenna,Peter J, AU - Sarró,Salvador, AU - Bernardo,Miguel, Y1 - 2015/06/23/ PY - 2015/02/19/received PY - 2015/05/21/revised PY - 2015/06/07/accepted PY - 2015/6/28/entrez PY - 2015/6/28/pubmed PY - 2016/5/3/medline KW - Assessment KW - Negative symptoms KW - Rating scale KW - Schizophrenia KW - Validation SP - 104 EP - 9 JF - Schizophrenia research JO - Schizophr. Res. VL - 166 IS - 1-3 N2 - Negative symptoms are a core feature of schizophrenia and their reliable and valid assessment is a prerequisite for developing effective therapeutic interventions. This study examined the psychometric properties and validity of the Spanish version of a new rating instrument, the Clinical Assessment Interview for Negative Symptoms (CAINS). Outpatients and inpatients (N=100) with DSM-IV schizophrenia were administered the translated CAINS, the Positive and Negative Syndrome Scale (PANSS), the Scale for the Assessment of Negative Symptoms (SANS), and the Calgary Depression Scale for Schizophrenia (CDSS). A subsample (N=46) was rated for Parkinsonism using the Extrapyramidal Symptoms Rating Scale (ESRS). The scale showed good inter-rater and intra-rater reliability. Both the CAINS overall and the subscales for motivation/pleasure (CAINS-Map) and expression (CAINS-Exp) scores correlated significantly with the SANS and PANSS negative symptom scale. Significant correlations with positive symptoms and general psychopathology were also found, but these reduced and mostly became insignificant when overall severity of illness was controlled for. Significant correlations with depression also disappeared when severity was controlled for. There was a trend-level correlation between the CAINS total score and Parkinsonism, which reflected an association with the CAINS-Exp subscale only. Factor analysis revealed a two-dimensional structure that explained the 67.44% of the variance. Overall, the Spanish version of the CAINS appears to be a valid tool for measuring negative symptoms in schizophrenia. SN - 1573-2509 UR - https://www.unboundmedicine.com/medline/citation/26116328/Validation_of_the_Spanish_version_of_the_Clinical_Assessment_for_Negative_Symptoms__CAINS__ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0920-9964(15)00321-7 DB - PRIME DP - Unbound Medicine ER -