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Whole Brain Volume Measured from 1.5T versus 3T MRI in Healthy Subjects and Patients with Multiple Sclerosis.
J Neuroimaging 2016 Jan-Feb; 26(1):62-7JN

Abstract

BACKGROUND

Whole brain atrophy is a putative outcome measure in monitoring relapsing-remitting multiple sclerosis (RRMS). With the ongoing MRI transformation from 1.5T to 3T, there is an unmet need to calibrate this change. We evaluated brain parenchymal volumes (BPVs) from 1.5T versus 3T in MS and normal controls (NC).

METHODS

We studied MS [n = 26, age (mean, range) 43 (21-55), 22 (85%) RRMS, Expanded Disability Status Scale (EDSS) 1.98 (0-6.5), timed 25 foot walk (T25FW) 5.95 (3.2-33.0 seconds)] and NC [n = 9, age 45 (31-53)]. Subjects underwent 1.5T (Phillips) and 3T (GE) 3-dimensional T1-weighted scans to derive normalized BPV from an automated SIENAX pipeline. Neuropsychological testing was according to consensus panel recommendations.

RESULTS

BPV-1.5T was higher than BPV-3T [mean (95% CI) + 45.7 mL (+35.3, +56.1), P < .00001], most likely due to improved tissue-CSF contrast at 3T. BPV-3T showed a larger volume decrease and larger effect size in detecting brain atrophy in MS versus NC [-74.5 mL (-126.5, -22.5), P = .006, d = .92] when compared to BPV-1.5T [-51.3.1 mL (-99.8, -2.8), P = .04, d = .67]. Correlations between BPV-1.5T and EDSS (r = -.43, P = .027) and BPV-3T and EDSS (r = -.49, P = .011) and between BPV-1.5T and T25FW (r = -.46, P = .018) and BPV-3T and T25FW (r = -.56, P = .003) slightly favored 3T. BPV-cognition correlations were significant (P < .05) for 6 of 11 subscales to a similar degree at 1.5T (r range = .44-.58) and 3T (r range = .43-.53).

CONCLUSIONS

Field strength may impact whole brain volume measurements in patients with MS though the differences are not too divergent between 1.5T and 3T.

Authors+Show Affiliations

Departments of Neurology, Brigham and Women's Hospital, Laboratory for Neuroimaging Research, Partners MS Center, Harvard Medical School, Boston, MA.Departments of Neurology, Brigham and Women's Hospital, Laboratory for Neuroimaging Research, Partners MS Center, Harvard Medical School, Boston, MA.Departments of Neurology, Brigham and Women's Hospital, Laboratory for Neuroimaging Research, Partners MS Center, Harvard Medical School, Boston, MA.Departments of Neurology, Brigham and Women's Hospital, Laboratory for Neuroimaging Research, Partners MS Center, Harvard Medical School, Boston, MA.Departments of Neurology, Brigham and Women's Hospital, Laboratory for Neuroimaging Research, Partners MS Center, Harvard Medical School, Boston, MA.Departments of Neurology, Brigham and Women's Hospital, Laboratory for Neuroimaging Research, Partners MS Center, Harvard Medical School, Boston, MA.Departments of Neurology, Brigham and Women's Hospital, Laboratory for Neuroimaging Research, Partners MS Center, Harvard Medical School, Boston, MA.Departments of Neurology, Brigham and Women's Hospital, Laboratory for Neuroimaging Research, Partners MS Center, Harvard Medical School, Boston, MA.Departments of Neurology, Brigham and Women's Hospital, Laboratory for Neuroimaging Research, Partners MS Center, Harvard Medical School, Boston, MA. Departments of Radiology, Brigham and Women's Hospital, Laboratory for Neuroimaging Research, Partners MS Center, Harvard Medical School, Boston, MA.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

26118637

Citation

Chu, Renxin, et al. "Whole Brain Volume Measured From 1.5T Versus 3T MRI in Healthy Subjects and Patients With Multiple Sclerosis." Journal of Neuroimaging : Official Journal of the American Society of Neuroimaging, vol. 26, no. 1, 2016, pp. 62-7.
Chu R, Tauhid S, Glanz BI, et al. Whole Brain Volume Measured from 1.5T versus 3T MRI in Healthy Subjects and Patients with Multiple Sclerosis. J Neuroimaging. 2016;26(1):62-7.
Chu, R., Tauhid, S., Glanz, B. I., Healy, B. C., Kim, G., Oommen, V. V., ... Bakshi, R. (2016). Whole Brain Volume Measured from 1.5T versus 3T MRI in Healthy Subjects and Patients with Multiple Sclerosis. Journal of Neuroimaging : Official Journal of the American Society of Neuroimaging, 26(1), pp. 62-7. doi:10.1111/jon.12271.
Chu R, et al. Whole Brain Volume Measured From 1.5T Versus 3T MRI in Healthy Subjects and Patients With Multiple Sclerosis. J Neuroimaging. 2016;26(1):62-7. PubMed PMID: 26118637.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Whole Brain Volume Measured from 1.5T versus 3T MRI in Healthy Subjects and Patients with Multiple Sclerosis. AU - Chu,Renxin, AU - Tauhid,Shahamat, AU - Glanz,Bonnie I, AU - Healy,Brian C, AU - Kim,Gloria, AU - Oommen,Vinit V, AU - Khalid,Fariha, AU - Neema,Mohit, AU - Bakshi,Rohit, Y1 - 2015/06/28/ PY - 2015/01/27/received PY - 2015/03/16/revised PY - 2015/03/18/accepted PY - 2015/6/30/entrez PY - 2015/6/30/pubmed PY - 2017/1/19/medline KW - 3T KW - MRI KW - Multiple sclerosis KW - atrophy KW - brain volume KW - cognitive impairment KW - disability SP - 62 EP - 7 JF - Journal of neuroimaging : official journal of the American Society of Neuroimaging JO - J Neuroimaging VL - 26 IS - 1 N2 - BACKGROUND: Whole brain atrophy is a putative outcome measure in monitoring relapsing-remitting multiple sclerosis (RRMS). With the ongoing MRI transformation from 1.5T to 3T, there is an unmet need to calibrate this change. We evaluated brain parenchymal volumes (BPVs) from 1.5T versus 3T in MS and normal controls (NC). METHODS: We studied MS [n = 26, age (mean, range) 43 (21-55), 22 (85%) RRMS, Expanded Disability Status Scale (EDSS) 1.98 (0-6.5), timed 25 foot walk (T25FW) 5.95 (3.2-33.0 seconds)] and NC [n = 9, age 45 (31-53)]. Subjects underwent 1.5T (Phillips) and 3T (GE) 3-dimensional T1-weighted scans to derive normalized BPV from an automated SIENAX pipeline. Neuropsychological testing was according to consensus panel recommendations. RESULTS: BPV-1.5T was higher than BPV-3T [mean (95% CI) + 45.7 mL (+35.3, +56.1), P < .00001], most likely due to improved tissue-CSF contrast at 3T. BPV-3T showed a larger volume decrease and larger effect size in detecting brain atrophy in MS versus NC [-74.5 mL (-126.5, -22.5), P = .006, d = .92] when compared to BPV-1.5T [-51.3.1 mL (-99.8, -2.8), P = .04, d = .67]. Correlations between BPV-1.5T and EDSS (r = -.43, P = .027) and BPV-3T and EDSS (r = -.49, P = .011) and between BPV-1.5T and T25FW (r = -.46, P = .018) and BPV-3T and T25FW (r = -.56, P = .003) slightly favored 3T. BPV-cognition correlations were significant (P < .05) for 6 of 11 subscales to a similar degree at 1.5T (r range = .44-.58) and 3T (r range = .43-.53). CONCLUSIONS: Field strength may impact whole brain volume measurements in patients with MS though the differences are not too divergent between 1.5T and 3T. SN - 1552-6569 UR - https://www.unboundmedicine.com/medline/citation/26118637/Whole_Brain_Volume_Measured_from_1_5T_versus_3T_MRI_in_Healthy_Subjects_and_Patients_with_Multiple_Sclerosis_ L2 - https://doi.org/10.1111/jon.12271 DB - PRIME DP - Unbound Medicine ER -