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The significance of caudate volume for age-related associative memory decline.
Brain Res 2015; 1622:137-48BR

Abstract

Aging comes along with reduced gray matter (GM) volume in several cerebral areas and with cognitive performance decline in different cognitive domains. Moreover, regional GM volume is linked to specific cognitive sub processes in older adults. However, it remains unclear which regional changes in older individuals are directly associated with decreased cognitive performance. Moreover, most of the studies on this topic focused on hippocampal and prefrontal brain regions and their relation to memory and executive functioning. Interestingly, there are only a few studies that reported an association between striatal brain volume and cognitive performance. This is insofar surprising that striatal structures are (1) highly affected by age and (2) involved in different neural circuits that serve intact cognition. To address these issues, voxel-based morphometry (VBM) was used to analyze GM volume in 18 younger and 18 older adults. Moreover, several neuropsychological tests from different neuropsychological test batteries were applied to assess a broad range of cognitive domains. Older adults showed less GM volume than younger adults within frontal, striatal, and cerebellar brain regions. In the group of older adults, significant correlations were found between striatal GM volume and memory performance and between prefrontal/temporal GM volume and executive functioning. The only direct overlap between brain regions associated with regional atrophy and cognitive performance in older adults was found for the right caudate: older adults showed reduced caudate volume relative to younger adults. Moreover, caudate volume was positively correlated with associative memory accuracy in older adults and older adults showed poorer performances than younger adults in the respective associative memory task. Taken together, the current findings indicate the relevance of the caudate for associative memory decline in the aging brain.

Authors+Show Affiliations

CognitiveNeuroScience at the Centre for Psychiatry, Justus Liebig University Giessen, Am Steg 24, 35385 Giessen, Germany. Electronic address: eva.bauer@psychiat.med.uni-giessen.de.Evangelic Hospital Bielefeld (EvKB), Department of Psychiatry and Psychotherapy Bethel, Research Department, Remterweg 69-71, 33617 Bielefeld, Germany; Evangelic Hospital Bielefeld (EvKB), Department of Psychiatry and Psychotherapy Bethel, Department of Geriatric Psychiatry, Bethesdaweg 12, 33617 Bielefeld, Germany.CognitiveNeuroScience at the Centre for Psychiatry, Justus Liebig University Giessen, Am Steg 24, 35385 Giessen, Germany.CognitiveNeuroScience at the Centre for Psychiatry, Justus Liebig University Giessen, Am Steg 24, 35385 Giessen, Germany.CognitiveNeuroScience at the Centre for Psychiatry, Justus Liebig University Giessen, Am Steg 24, 35385 Giessen, Germany; Department of Psychology, Justus Liebig University Giessen, Otto-Behaghel-Straβe 10, 35394 Giessen, Germany; Bender Institute of Neuroimaging, University of Giessen, Otto-Behaghel-Str. 10H, 35394 Giessen, Germany.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

26119913

Citation

Bauer, E, et al. "The Significance of Caudate Volume for Age-related Associative Memory Decline." Brain Research, vol. 1622, 2015, pp. 137-48.
Bauer E, Toepper M, Gebhardt H, et al. The significance of caudate volume for age-related associative memory decline. Brain Res. 2015;1622:137-48.
Bauer, E., Toepper, M., Gebhardt, H., Gallhofer, B., & Sammer, G. (2015). The significance of caudate volume for age-related associative memory decline. Brain Research, 1622, pp. 137-48. doi:10.1016/j.brainres.2015.06.026.
Bauer E, et al. The Significance of Caudate Volume for Age-related Associative Memory Decline. Brain Res. 2015 Oct 5;1622:137-48. PubMed PMID: 26119913.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The significance of caudate volume for age-related associative memory decline. AU - Bauer,E, AU - Toepper,M, AU - Gebhardt,H, AU - Gallhofer,B, AU - Sammer,G, Y1 - 2015/06/25/ PY - 2015/02/26/received PY - 2015/06/03/revised PY - 2015/06/18/accepted PY - 2015/6/30/entrez PY - 2015/6/30/pubmed PY - 2016/6/3/medline KW - Aging KW - Associative memory KW - Caudate KW - Striatal KW - VBM SP - 137 EP - 48 JF - Brain research JO - Brain Res. VL - 1622 N2 - Aging comes along with reduced gray matter (GM) volume in several cerebral areas and with cognitive performance decline in different cognitive domains. Moreover, regional GM volume is linked to specific cognitive sub processes in older adults. However, it remains unclear which regional changes in older individuals are directly associated with decreased cognitive performance. Moreover, most of the studies on this topic focused on hippocampal and prefrontal brain regions and their relation to memory and executive functioning. Interestingly, there are only a few studies that reported an association between striatal brain volume and cognitive performance. This is insofar surprising that striatal structures are (1) highly affected by age and (2) involved in different neural circuits that serve intact cognition. To address these issues, voxel-based morphometry (VBM) was used to analyze GM volume in 18 younger and 18 older adults. Moreover, several neuropsychological tests from different neuropsychological test batteries were applied to assess a broad range of cognitive domains. Older adults showed less GM volume than younger adults within frontal, striatal, and cerebellar brain regions. In the group of older adults, significant correlations were found between striatal GM volume and memory performance and between prefrontal/temporal GM volume and executive functioning. The only direct overlap between brain regions associated with regional atrophy and cognitive performance in older adults was found for the right caudate: older adults showed reduced caudate volume relative to younger adults. Moreover, caudate volume was positively correlated with associative memory accuracy in older adults and older adults showed poorer performances than younger adults in the respective associative memory task. Taken together, the current findings indicate the relevance of the caudate for associative memory decline in the aging brain. SN - 1872-6240 UR - https://www.unboundmedicine.com/medline/citation/26119913/The_significance_of_caudate_volume_for_age_related_associative_memory_decline_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0006-8993(15)00497-7 DB - PRIME DP - Unbound Medicine ER -