Tags

Type your tag names separated by a space and hit enter

Relation of high plasma triglyceride levels associated with obesity and regional adipose tissue distribution to plasma lipoprotein-lipid composition in premenopausal women.
Clin Invest Med. 1989 Dec; 12(6):374-80.CI

Abstract

Abdominal obesity is associated with high plasma triglyceride (TG) and with low plasma high density lipoprotein (HDL)-cholesterol (CHOL) levels. As plasma TG and HDL-CHOL are negatively correlated, the associations between obesity, the regional distribution of body fat, plasma TG levels, and plasma lipoprotein concentration and composition were studied in a sample of 76 premenopausal women (52 obese and 24 non-obese). Obese women had significantly higher plasma levels of VLDL-TG, low density lipoprotein (LDL)-CHOL, LDL-TG, LDL-apolipoprotein (apo) B and reduced HDL-CHOL levels compared to non-obese controls (p less than 0.01). However, plasma concentrations of HDL-apo A-I and HDL-TG were not different between obese and non-obese women. Partial correlation analyses revealed that both fat mass and abdominal fat accumulation significantly contributed to VLDL-TG and HDL-CHOL variances. After control for body fat mass, the waist-to-hip circumference ratio (WHR) remained significantly correlated with plasma LDL-apo B levels and with the LDL-apo B/LDL-CHOL ratio (0.01 greater than p less than 0.05). Body fat mass was, however, associated with TG enrichment of LDL (p less than 0.01). After control for WHR, body fat mass showed no significant association with plasma HDL-TG levels, whereas the WHR was positively correlated with HDL-TG levels (p less than 0.05). Partial correlation analyses indicated that adjustment for fat mass or for the WHR failed to eliminate the associations between plasma VLDL-TG levels and lipoprotein lipid composition. This study emphasizes the importance of plasma VLDL-TG level as a correlate of plasma LDL and HDL lipid composition in abdominal obesity.

Authors+Show Affiliations

Physical Activity Sciences Laboratory, Laval University, Ste-Foy, Quebec.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

2612090

Citation

Després, J P., et al. "Relation of High Plasma Triglyceride Levels Associated With Obesity and Regional Adipose Tissue Distribution to Plasma Lipoprotein-lipid Composition in Premenopausal Women." Clinical and Investigative Medicine. Medecine Clinique Et Experimentale, vol. 12, no. 6, 1989, pp. 374-80.
Després JP, Moorjani S, Tremblay A, et al. Relation of high plasma triglyceride levels associated with obesity and regional adipose tissue distribution to plasma lipoprotein-lipid composition in premenopausal women. Clin Invest Med. 1989;12(6):374-80.
Després, J. P., Moorjani, S., Tremblay, A., Ferland, M., Lupien, P. J., Nadeau, A., & Bouchard, C. (1989). Relation of high plasma triglyceride levels associated with obesity and regional adipose tissue distribution to plasma lipoprotein-lipid composition in premenopausal women. Clinical and Investigative Medicine. Medecine Clinique Et Experimentale, 12(6), 374-80.
Després JP, et al. Relation of High Plasma Triglyceride Levels Associated With Obesity and Regional Adipose Tissue Distribution to Plasma Lipoprotein-lipid Composition in Premenopausal Women. Clin Invest Med. 1989;12(6):374-80. PubMed PMID: 2612090.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Relation of high plasma triglyceride levels associated with obesity and regional adipose tissue distribution to plasma lipoprotein-lipid composition in premenopausal women. AU - Després,J P, AU - Moorjani,S, AU - Tremblay,A, AU - Ferland,M, AU - Lupien,P J, AU - Nadeau,A, AU - Bouchard,C, PY - 1989/12/1/pubmed PY - 1989/12/1/medline PY - 1989/12/1/entrez SP - 374 EP - 80 JF - Clinical and investigative medicine. Medecine clinique et experimentale JO - Clin Invest Med VL - 12 IS - 6 N2 - Abdominal obesity is associated with high plasma triglyceride (TG) and with low plasma high density lipoprotein (HDL)-cholesterol (CHOL) levels. As plasma TG and HDL-CHOL are negatively correlated, the associations between obesity, the regional distribution of body fat, plasma TG levels, and plasma lipoprotein concentration and composition were studied in a sample of 76 premenopausal women (52 obese and 24 non-obese). Obese women had significantly higher plasma levels of VLDL-TG, low density lipoprotein (LDL)-CHOL, LDL-TG, LDL-apolipoprotein (apo) B and reduced HDL-CHOL levels compared to non-obese controls (p less than 0.01). However, plasma concentrations of HDL-apo A-I and HDL-TG were not different between obese and non-obese women. Partial correlation analyses revealed that both fat mass and abdominal fat accumulation significantly contributed to VLDL-TG and HDL-CHOL variances. After control for body fat mass, the waist-to-hip circumference ratio (WHR) remained significantly correlated with plasma LDL-apo B levels and with the LDL-apo B/LDL-CHOL ratio (0.01 greater than p less than 0.05). Body fat mass was, however, associated with TG enrichment of LDL (p less than 0.01). After control for WHR, body fat mass showed no significant association with plasma HDL-TG levels, whereas the WHR was positively correlated with HDL-TG levels (p less than 0.05). Partial correlation analyses indicated that adjustment for fat mass or for the WHR failed to eliminate the associations between plasma VLDL-TG levels and lipoprotein lipid composition. This study emphasizes the importance of plasma VLDL-TG level as a correlate of plasma LDL and HDL lipid composition in abdominal obesity. SN - 0147-958X UR - https://www.unboundmedicine.com/medline/citation/2612090/Relation_of_high_plasma_triglyceride_levels_associated_with_obesity_and_regional_adipose_tissue_distribution_to_plasma_lipoprotein_lipid_composition_in_premenopausal_women_ L2 - http://www.diseaseinfosearch.org/result/9028 DB - PRIME DP - Unbound Medicine ER -