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Effects of Selenium Supplementation on Spontaneous Autoimmune Thyroiditis in NOD.H-2h4 Mice.
Thyroid. 2015 Oct; 25(10):1137-44.T

Abstract

BACKGROUND

Recent clinical studies have demonstrated the suppressive effect of selenium (Se) treatment on serum thyroid-specific antibody titers in patients with autoimmune thyroiditis (AIT), but the mechanism underlying this process is not clear. The aim of the present study was to investigate the effects of selenium on the incidence and severity of AIT, titers of thyroid autoantibodies, and selenoprotein expression in thyroid in a spontaneous autoimmune thyroiditis (SAT) model.

METHODS

NOD.H-2(h4) mice at four weeks of age were randomly divided into control, iodine supplement (SAT), and selenium supplement groups (SAT+Se). Mice were given 0.005% sodium iodide water for eight weeks to induce SAT and then 0.3 mg/L sodium selenite in drinking water for 8 weeks and 16 weeks. The severity of lymphocytic infiltration in the thyroid, serum thyroglobulin antibody (TgAb) titers, serum selenium concentration, expression of glutathione peroxidase-1 (GPx1), thioredoxin reductase-1 (Txnrd1), and peroxiredoxin 5 were measured.

RESULTS

Serum selenium concentration significantly increased after selenium supplementation. Serum TgAb levels were significantly lower in the selenium group compared with the SAT group (p<0.05). The prevalence of thyroiditis and the degree of infiltration of lymphocytes decreased gradually over time in the group provided with selenium supplementation. The expression of GPx1 and Txnrd1 by Western blotting were found to be significantly higher in the SAT+Se group than in other groups (p<0.05).

CONCLUSIONS

These results indicate that selenium treatment can increase the function of antioxidation by upregulating the expression of selenoproteins in the thyroid and have an inhibitory effect on TgAb titers, which may have an impact on AIT.

Authors+Show Affiliations

1 The Endocrine Institute and The Liaoning Provincial Key Laboratory of Endocrine Diseases , Shenyang, P.R. China . 2 Department of Endocrinology and Metabolism, The First Hospital of China Medical University , Shenyang, P.R. China .1 The Endocrine Institute and The Liaoning Provincial Key Laboratory of Endocrine Diseases , Shenyang, P.R. China .1 The Endocrine Institute and The Liaoning Provincial Key Laboratory of Endocrine Diseases , Shenyang, P.R. China . 2 Department of Endocrinology and Metabolism, The First Hospital of China Medical University , Shenyang, P.R. China .1 The Endocrine Institute and The Liaoning Provincial Key Laboratory of Endocrine Diseases , Shenyang, P.R. China .1 The Endocrine Institute and The Liaoning Provincial Key Laboratory of Endocrine Diseases , Shenyang, P.R. China .1 The Endocrine Institute and The Liaoning Provincial Key Laboratory of Endocrine Diseases , Shenyang, P.R. China .1 The Endocrine Institute and The Liaoning Provincial Key Laboratory of Endocrine Diseases , Shenyang, P.R. China .1 The Endocrine Institute and The Liaoning Provincial Key Laboratory of Endocrine Diseases , Shenyang, P.R. China . 2 Department of Endocrinology and Metabolism, The First Hospital of China Medical University , Shenyang, P.R. China .1 The Endocrine Institute and The Liaoning Provincial Key Laboratory of Endocrine Diseases , Shenyang, P.R. China . 2 Department of Endocrinology and Metabolism, The First Hospital of China Medical University , Shenyang, P.R. China .

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

26121912

Citation

Wang, Weiwei, et al. "Effects of Selenium Supplementation On Spontaneous Autoimmune Thyroiditis in NOD.H-2h4 Mice." Thyroid : Official Journal of the American Thyroid Association, vol. 25, no. 10, 2015, pp. 1137-44.
Wang W, Xue H, Li Y, et al. Effects of Selenium Supplementation on Spontaneous Autoimmune Thyroiditis in NOD.H-2h4 Mice. Thyroid. 2015;25(10):1137-44.
Wang, W., Xue, H., Li, Y., Hou, X., Fan, C., Wang, H., Zhang, H., Shan, Z., & Teng, W. (2015). Effects of Selenium Supplementation on Spontaneous Autoimmune Thyroiditis in NOD.H-2h4 Mice. Thyroid : Official Journal of the American Thyroid Association, 25(10), 1137-44. https://doi.org/10.1089/thy.2014.0568
Wang W, et al. Effects of Selenium Supplementation On Spontaneous Autoimmune Thyroiditis in NOD.H-2h4 Mice. Thyroid. 2015;25(10):1137-44. PubMed PMID: 26121912.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effects of Selenium Supplementation on Spontaneous Autoimmune Thyroiditis in NOD.H-2h4 Mice. AU - Wang,Weiwei, AU - Xue,Haibo, AU - Li,Yushu, AU - Hou,Xin, AU - Fan,Chenling, AU - Wang,Hong, AU - Zhang,Hongmei, AU - Shan,Zhongyan, AU - Teng,Weiping, Y1 - 2015/08/26/ PY - 2015/7/1/entrez PY - 2015/7/1/pubmed PY - 2016/7/1/medline SP - 1137 EP - 44 JF - Thyroid : official journal of the American Thyroid Association JO - Thyroid VL - 25 IS - 10 N2 - BACKGROUND: Recent clinical studies have demonstrated the suppressive effect of selenium (Se) treatment on serum thyroid-specific antibody titers in patients with autoimmune thyroiditis (AIT), but the mechanism underlying this process is not clear. The aim of the present study was to investigate the effects of selenium on the incidence and severity of AIT, titers of thyroid autoantibodies, and selenoprotein expression in thyroid in a spontaneous autoimmune thyroiditis (SAT) model. METHODS: NOD.H-2(h4) mice at four weeks of age were randomly divided into control, iodine supplement (SAT), and selenium supplement groups (SAT+Se). Mice were given 0.005% sodium iodide water for eight weeks to induce SAT and then 0.3 mg/L sodium selenite in drinking water for 8 weeks and 16 weeks. The severity of lymphocytic infiltration in the thyroid, serum thyroglobulin antibody (TgAb) titers, serum selenium concentration, expression of glutathione peroxidase-1 (GPx1), thioredoxin reductase-1 (Txnrd1), and peroxiredoxin 5 were measured. RESULTS: Serum selenium concentration significantly increased after selenium supplementation. Serum TgAb levels were significantly lower in the selenium group compared with the SAT group (p<0.05). The prevalence of thyroiditis and the degree of infiltration of lymphocytes decreased gradually over time in the group provided with selenium supplementation. The expression of GPx1 and Txnrd1 by Western blotting were found to be significantly higher in the SAT+Se group than in other groups (p<0.05). CONCLUSIONS: These results indicate that selenium treatment can increase the function of antioxidation by upregulating the expression of selenoproteins in the thyroid and have an inhibitory effect on TgAb titers, which may have an impact on AIT. SN - 1557-9077 UR - https://www.unboundmedicine.com/medline/citation/26121912/Effects_of_Selenium_Supplementation_on_Spontaneous_Autoimmune_Thyroiditis_in_NOD_H_2h4_Mice_ L2 - https://www.liebertpub.com/doi/full/10.1089/thy.2014.0568?url_ver=Z39.88-2003&amp;rfr_id=ori:rid:crossref.org&amp;rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -