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Severe sleep apnea-hypopnea syndrome is related to left ventricle dysfunction and hypertrophy in acromegalic patients.
Endocrinol Nutr. 2015 Oct; 62(8):366-72.EN

Abstract

OBJECTIVE

To assess whether sleep apnea-hypopnea syndrome (SAHS) is a risk factor for development of acromegalic cardiomyopathy.

METHODS

A descriptive, cross-sectional study of 32 patients with acromegaly (15 categorized as non-controlled-NCA and 17 as controlled-CA) compared to 20 matched controls (by sex, age, and BMI) referred to the pulmonology department for suspected SAHS. Polysomnography, echocardiography (M-mode, 2-dimensional, and Doppler), and 12-lead electrocardiography were performed in all participants. Development of cardiac morbidity (ischemia heart disease or heart failure) was evaluated after 7 years.

RESULTS

SAHS was diagnosed in 81.3% of patients with acromegaly and 85% of controls. Mild SAHS was more common in CA than in NCA patients (31.3% vs. 0%, p=0.048). There was a trend to greater prevalence of left ventricular diastolic dysfunction (LVDD) in acromegalic patients as compared to controls (58.1% vs. 30%, p=0.05). Presence of severe SAHS in patients with acromegaly was related to greater risk of LVDD (90.9% vs. 40%, p=0.008; OR 2.3 [1.3-4.0]), LV hypertrophy (55.6% vs. 10.5%, p=0.02; OR 5.3 [1.3-22.2]), and cardiac events (87.5% vs. 35.6%; p=0.01; OR 7.53 [1.07-53.24]).

CONCLUSION

SAHS is highly prevalent in patients with acromegaly. Only in these patients was severe SAHS associated to hypertrophy, LV diastolic dysfunction, and cardiac events.

Authors+Show Affiliations

Endocrine Department, Hospital General Universitario Alicante, Alicante, Spain. Electronic address: ruthsanchez@coma.es.Cardiology Department, Hospital General Universitario Alicante, Alicante, Spain.Endocrine Department, Hospital General Universitario Alicante, Alicante, Spain.Pneumology Department, Hospital General Universitario Alicante, Alicante, Spain.Endocrine Department, Hospital General Universitario Alicante, Alicante, Spain.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

26122359

Citation

Sanchez-Ortiga, Ruth, et al. "Severe Sleep Apnea-hypopnea Syndrome Is Related to Left Ventricle Dysfunction and Hypertrophy in Acromegalic Patients." Endocrinologia Y Nutricion : Organo De La Sociedad Espanola De Endocrinologia Y Nutricion, vol. 62, no. 8, 2015, pp. 366-72.
Sanchez-Ortiga R, Climent V, Sanchez-Tejada L, et al. Severe sleep apnea-hypopnea syndrome is related to left ventricle dysfunction and hypertrophy in acromegalic patients. Endocrinol Nutr. 2015;62(8):366-72.
Sanchez-Ortiga, R., Climent, V., Sanchez-Tejada, L., Candela, A., & Pico, A. (2015). Severe sleep apnea-hypopnea syndrome is related to left ventricle dysfunction and hypertrophy in acromegalic patients. Endocrinologia Y Nutricion : Organo De La Sociedad Espanola De Endocrinologia Y Nutricion, 62(8), 366-72. https://doi.org/10.1016/j.endonu.2015.05.007
Sanchez-Ortiga R, et al. Severe Sleep Apnea-hypopnea Syndrome Is Related to Left Ventricle Dysfunction and Hypertrophy in Acromegalic Patients. Endocrinol Nutr. 2015;62(8):366-72. PubMed PMID: 26122359.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Severe sleep apnea-hypopnea syndrome is related to left ventricle dysfunction and hypertrophy in acromegalic patients. AU - Sanchez-Ortiga,Ruth, AU - Climent,Vicente, AU - Sanchez-Tejada,Laura, AU - Candela,Alfredo, AU - Pico,Antonio, Y1 - 2015/06/27/ PY - 2014/12/17/received PY - 2015/04/30/revised PY - 2015/05/05/accepted PY - 2015/7/1/entrez PY - 2015/7/1/pubmed PY - 2017/4/30/medline KW - Acromegalia KW - Acromegaly KW - Cardiomiopatía KW - Cardiomyopathy KW - Sleep apnea–hypopnea syndrome KW - Sleep-disordered breathing KW - Síndrome de apnea-hipopnea del sueño KW - Transtorno respiratorio del sueño SP - 366 EP - 72 JF - Endocrinologia y nutricion : organo de la Sociedad Espanola de Endocrinologia y Nutricion JO - Endocrinol Nutr VL - 62 IS - 8 N2 - OBJECTIVE: To assess whether sleep apnea-hypopnea syndrome (SAHS) is a risk factor for development of acromegalic cardiomyopathy. METHODS: A descriptive, cross-sectional study of 32 patients with acromegaly (15 categorized as non-controlled-NCA and 17 as controlled-CA) compared to 20 matched controls (by sex, age, and BMI) referred to the pulmonology department for suspected SAHS. Polysomnography, echocardiography (M-mode, 2-dimensional, and Doppler), and 12-lead electrocardiography were performed in all participants. Development of cardiac morbidity (ischemia heart disease or heart failure) was evaluated after 7 years. RESULTS: SAHS was diagnosed in 81.3% of patients with acromegaly and 85% of controls. Mild SAHS was more common in CA than in NCA patients (31.3% vs. 0%, p=0.048). There was a trend to greater prevalence of left ventricular diastolic dysfunction (LVDD) in acromegalic patients as compared to controls (58.1% vs. 30%, p=0.05). Presence of severe SAHS in patients with acromegaly was related to greater risk of LVDD (90.9% vs. 40%, p=0.008; OR 2.3 [1.3-4.0]), LV hypertrophy (55.6% vs. 10.5%, p=0.02; OR 5.3 [1.3-22.2]), and cardiac events (87.5% vs. 35.6%; p=0.01; OR 7.53 [1.07-53.24]). CONCLUSION: SAHS is highly prevalent in patients with acromegaly. Only in these patients was severe SAHS associated to hypertrophy, LV diastolic dysfunction, and cardiac events. SN - 1579-2021 UR - https://www.unboundmedicine.com/medline/citation/26122359/Severe_sleep_apnea_hypopnea_syndrome_is_related_to_left_ventricle_dysfunction_and_hypertrophy_in_acromegalic_patients_ L2 - http://linkinghub.elsevier.com/retrieve/pii/S1575-0922(15)00151-5 DB - PRIME DP - Unbound Medicine ER -