Tags

Type your tag names separated by a space and hit enter

Assessment of left ventricular function by tissue Doppler echocardiography in pediatric chronic kidney disease.
Ren Fail. 2015 Aug; 37(7):1094-9.RF

Abstract

BACKGROUND

Cardiovascular (CV) disease remains the most common cause of mortality in chronic kidney disease (CKD).

METHODS

In this cross-sectional study, 43 pediatric patients with CKD were divided into two groups according to their estimated glomerular filtration rate (eGFR): groups 1 and 2 (eGR; 29-75 and 15-29 mL/min/1.73 m(2), respectively). M - mode, conventional pulsed wave Doppler (cPWD) echocardiography and tissue Doppler imaging (TDI) were performed in all patients and 16 healthy controls. Maximal early (E wave) and late (A wave) diastolic flow velocities were assessed by cPWD. Using TDI, the early (E') and late (A') diastolic filling velocities were recorded. Early and late diastoles were evaluated using E' values and E/E' ratios, respectively.

RESULTS

Left ventricular hypertrophy (LVH) was determined in 19/43 (44.2%) patients. The E/E' ratio was significantly higher in group 2 than in group 1 and controls. E/E' was found to be positively correlated with left ventricular mass (LVM) index, and negatively with hemoglobin (Hb) levels. Low Hb levels were only independent predictor of E/E' (p = 0.001, β: -0.470, 95% CI: -0.764; -0.196). E' ratio was significantly lower in both patient groups compared to the controls.

CONCLUSIONS

LVH and diastolic dysfunction are already present in early stages of CKD. Treatment of risk factors, such as anemia, is important to improve the clinical outcome.

Authors+Show Affiliations

a Division of Pediatric Nephrology , University of Akdeniz , Antalya , Turkey .a Division of Pediatric Nephrology , University of Akdeniz , Antalya , Turkey .b Division of Pediatric Cardiology , University of Akdeniz , Antalya , Turkey , and.c Department of Medical Biochemistry , University of Akdeniz , Antalya , Turkey.a Division of Pediatric Nephrology , University of Akdeniz , Antalya , Turkey .a Division of Pediatric Nephrology , University of Akdeniz , Antalya , Turkey .b Division of Pediatric Cardiology , University of Akdeniz , Antalya , Turkey , and.a Division of Pediatric Nephrology , University of Akdeniz , Antalya , Turkey .

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

26123267

Citation

Dogan, Cagla Serpil, et al. "Assessment of Left Ventricular Function By Tissue Doppler Echocardiography in Pediatric Chronic Kidney Disease." Renal Failure, vol. 37, no. 7, 2015, pp. 1094-9.
Dogan CS, Akman S, Simsek A, et al. Assessment of left ventricular function by tissue Doppler echocardiography in pediatric chronic kidney disease. Ren Fail. 2015;37(7):1094-9.
Dogan, C. S., Akman, S., Simsek, A., Ozdem, S., Comak, E., Gokceoglu, A. U., Kardelen, F., & Koyun, M. (2015). Assessment of left ventricular function by tissue Doppler echocardiography in pediatric chronic kidney disease. Renal Failure, 37(7), 1094-9. https://doi.org/10.3109/0886022X.2015.1061301
Dogan CS, et al. Assessment of Left Ventricular Function By Tissue Doppler Echocardiography in Pediatric Chronic Kidney Disease. Ren Fail. 2015;37(7):1094-9. PubMed PMID: 26123267.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Assessment of left ventricular function by tissue Doppler echocardiography in pediatric chronic kidney disease. AU - Dogan,Cagla Serpil, AU - Akman,Sema, AU - Simsek,Ayse, AU - Ozdem,Sebahat, AU - Comak,Elif, AU - Gokceoglu,Arife Uslu, AU - Kardelen,Fırat, AU - Koyun,Mustafa, Y1 - 2015/06/30/ PY - 2015/7/1/entrez PY - 2015/7/1/pubmed PY - 2016/6/21/medline KW - Child KW - chronic kidney disease KW - conventional pulsed wave Doppler echocardiography KW - left ventricular function KW - tissue Doppler imaging SP - 1094 EP - 9 JF - Renal failure JO - Ren Fail VL - 37 IS - 7 N2 - BACKGROUND: Cardiovascular (CV) disease remains the most common cause of mortality in chronic kidney disease (CKD). METHODS: In this cross-sectional study, 43 pediatric patients with CKD were divided into two groups according to their estimated glomerular filtration rate (eGFR): groups 1 and 2 (eGR; 29-75 and 15-29 mL/min/1.73 m(2), respectively). M - mode, conventional pulsed wave Doppler (cPWD) echocardiography and tissue Doppler imaging (TDI) were performed in all patients and 16 healthy controls. Maximal early (E wave) and late (A wave) diastolic flow velocities were assessed by cPWD. Using TDI, the early (E') and late (A') diastolic filling velocities were recorded. Early and late diastoles were evaluated using E' values and E/E' ratios, respectively. RESULTS: Left ventricular hypertrophy (LVH) was determined in 19/43 (44.2%) patients. The E/E' ratio was significantly higher in group 2 than in group 1 and controls. E/E' was found to be positively correlated with left ventricular mass (LVM) index, and negatively with hemoglobin (Hb) levels. Low Hb levels were only independent predictor of E/E' (p = 0.001, β: -0.470, 95% CI: -0.764; -0.196). E' ratio was significantly lower in both patient groups compared to the controls. CONCLUSIONS: LVH and diastolic dysfunction are already present in early stages of CKD. Treatment of risk factors, such as anemia, is important to improve the clinical outcome. SN - 1525-6049 UR - https://www.unboundmedicine.com/medline/citation/26123267/Assessment_of_left_ventricular_function_by_tissue_Doppler_echocardiography_in_pediatric_chronic_kidney_disease_ L2 - https://www.tandfonline.com/doi/full/10.3109/0886022X.2015.1061301 DB - PRIME DP - Unbound Medicine ER -