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Usefulness of impulse oscillometry for the assessment of airway hyperresponsiveness in mild-to-moderate adult asthma.
Ann Allergy Asthma Immunol 2015; 115(1):17-20AA

Abstract

BACKGROUND

Impulse oscillometry (IOS) is a novel method of assessing airway resistance. IOS is rarely used in assessing airway resistance after bronchoprovocation in adult asthma.

OBJECTIVE

To ascertain the degree of change in IOS measurements seen in patients with asthma undergoing bronchial challenge testing.

METHODS

Patients 18 to 65 years old with mild to moderate asthma, forced expiratory volume in 1 second (FEV1) greater than 80% predicted, and diurnal FEV1 variation less than 30% and taking inhaled corticosteroid (≤1,000 μg/day of beclomethasone dipropionate equivalent dose) were recruited. Sequential spirometry and IOS results were measured during bronchial challenge testing to inhaled methacholine and histamine.

RESULTS

The magnitude of percentage of change demonstrated in total airway resistance at 5 Hz was greater than that observed for FEV1 in the 2 bronchial challenge tests. For example, at a methacholine provocation concentration that caused a decrease in FEV1 of 20%, a 43.5% change (95% confidence interval 29.4-57.5) was seen in total airway resistance at 5 Hz as measured by IOS compared with a 23.3% change (95% confidence interval 18.7-27.9) in FEV1. The magnitude of change seen with other IOS outcomes, including peripheral airway resistance, area under the curve, and resonant frequency, also was greater compared with spirometry.

CONCLUSION

The potential application of IOS in the assessment of airway hyperresponsiveness in adult asthma has been demonstrated. Further population studies are required.

TRIAL REGISTRATION

www.clinicaltrials.gov (NCT01074853).

Authors+Show Affiliations

Scottish Centre for Respiratory Research, Medical Research Institute, Ninewells Hospital, University of Dundee, Dundee, Scotland.Scottish Centre for Respiratory Research, Medical Research Institute, Ninewells Hospital, University of Dundee, Dundee, Scotland.Scottish Centre for Respiratory Research, Medical Research Institute, Ninewells Hospital, University of Dundee, Dundee, Scotland.Scottish Centre for Respiratory Research, Medical Research Institute, Ninewells Hospital, University of Dundee, Dundee, Scotland. Electronic address: b.j.lipworth@dundee.ac.uk.

Pub Type(s)

Comparative Study
Evaluation Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

26123421

Citation

Short, Philip M., et al. "Usefulness of Impulse Oscillometry for the Assessment of Airway Hyperresponsiveness in Mild-to-moderate Adult Asthma." Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology, vol. 115, no. 1, 2015, pp. 17-20.
Short PM, Anderson WJ, Manoharan A, et al. Usefulness of impulse oscillometry for the assessment of airway hyperresponsiveness in mild-to-moderate adult asthma. Ann Allergy Asthma Immunol. 2015;115(1):17-20.
Short, P. M., Anderson, W. J., Manoharan, A., & Lipworth, B. J. (2015). Usefulness of impulse oscillometry for the assessment of airway hyperresponsiveness in mild-to-moderate adult asthma. Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology, 115(1), pp. 17-20. doi:10.1016/j.anai.2015.04.022.
Short PM, et al. Usefulness of Impulse Oscillometry for the Assessment of Airway Hyperresponsiveness in Mild-to-moderate Adult Asthma. Ann Allergy Asthma Immunol. 2015;115(1):17-20. PubMed PMID: 26123421.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Usefulness of impulse oscillometry for the assessment of airway hyperresponsiveness in mild-to-moderate adult asthma. AU - Short,Philip M, AU - Anderson,William J, AU - Manoharan,Arvind, AU - Lipworth,Brian J, PY - 2015/02/04/received PY - 2015/04/02/revised PY - 2015/04/17/accepted PY - 2015/7/1/entrez PY - 2015/7/1/pubmed PY - 2015/9/12/medline SP - 17 EP - 20 JF - Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology JO - Ann. Allergy Asthma Immunol. VL - 115 IS - 1 N2 - BACKGROUND: Impulse oscillometry (IOS) is a novel method of assessing airway resistance. IOS is rarely used in assessing airway resistance after bronchoprovocation in adult asthma. OBJECTIVE: To ascertain the degree of change in IOS measurements seen in patients with asthma undergoing bronchial challenge testing. METHODS: Patients 18 to 65 years old with mild to moderate asthma, forced expiratory volume in 1 second (FEV1) greater than 80% predicted, and diurnal FEV1 variation less than 30% and taking inhaled corticosteroid (≤1,000 μg/day of beclomethasone dipropionate equivalent dose) were recruited. Sequential spirometry and IOS results were measured during bronchial challenge testing to inhaled methacholine and histamine. RESULTS: The magnitude of percentage of change demonstrated in total airway resistance at 5 Hz was greater than that observed for FEV1 in the 2 bronchial challenge tests. For example, at a methacholine provocation concentration that caused a decrease in FEV1 of 20%, a 43.5% change (95% confidence interval 29.4-57.5) was seen in total airway resistance at 5 Hz as measured by IOS compared with a 23.3% change (95% confidence interval 18.7-27.9) in FEV1. The magnitude of change seen with other IOS outcomes, including peripheral airway resistance, area under the curve, and resonant frequency, also was greater compared with spirometry. CONCLUSION: The potential application of IOS in the assessment of airway hyperresponsiveness in adult asthma has been demonstrated. Further population studies are required. TRIAL REGISTRATION: www.clinicaltrials.gov (NCT01074853). SN - 1534-4436 UR - https://www.unboundmedicine.com/medline/citation/26123421/Usefulness_of_impulse_oscillometry_for_the_assessment_of_airway_hyperresponsiveness_in_mild_to_moderate_adult_asthma_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1081-1206(15)00302-6 DB - PRIME DP - Unbound Medicine ER -