Tags

Type your tag names separated by a space and hit enter

Bronchial hyperresponsiveness, airway inflammation, and reversibility in patients with chronic obstructive pulmonary disease.

Abstract

BACKGROUND

Bronchial hyperresponsiveness (BHR), sputum eosinophilia, and bronchial reversibility are often thought to be a hallmark of asthma, yet it has been shown to occur in COPD as well.

OBJECTIVES

To evaluate the relationship between BHR, lung function, and airway inflammation in COPD patients.

METHODS

Thirty-one, steroid-free patients with stable, mild and moderate COPD were studied. The following tests were carried out: baseline lung function, reversibility, provocative dose of methacholine causing a 20% fall in forced expiratory volume in 1 second, a COPD symptom score, and sputum induction.

RESULTS

Twenty-nine patients completed the procedures. About 41.4% had BHR, 31.0% had increased sputum eosinophils, and 37.9% had bronchial reversibility. Some of the patients had only one of these characteristics while others had two or the three of them. Patients with BHR had higher sputum eosinophils than patients without BHR (P=0.046) and those with sputum eosinophils ≥3% had more exacerbations in the previous year and a higher COPD symptom score than patients with sputum eosinophils <3% (P=0.019 and P=0.031, respectively). In patients with BHR, the cumulative dose of methacholine was negatively related to the symptom score and the number of exacerbations in the previous year. When patients with bronchial reversibility were considered, bronchodilation was positively related to sputum eosinophils.

CONCLUSION

Our study showed that BHR, sputum eosinophilia, and bronchial reversibility were not clustered in one single phenotype of COPD but could be present alone or together. Of interest, BHR and airway eosinophilia were associated with clinical data in terms of exacerbations and symptoms. Further investigation is needed to clarify this topic.

Authors+Show Affiliations

Division of Pneumology, IRCCS Rehabilitation Institute of Tradate, Salvatore Maugeri Foundation (IRCCS), Tradate, Italy.Division of Pneumology, IRCCS Rehabilitation Institute of Tradate, Salvatore Maugeri Foundation (IRCCS), Tradate, Italy.Division of Pneumology, IRCCS Rehabilitation Institute of Tradate, Salvatore Maugeri Foundation (IRCCS), Tradate, Italy.Allergy and Immunology Unit, Salvatore Maugeri Foundation (IRCCS), Pavia, Italy.Allergy and Immunology Unit, Salvatore Maugeri Foundation (IRCCS), Pavia, Italy.Department of Clinical and Experimental Medicine, University of Insubria, Varese, Italy.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

26124655

Citation

Zanini, Andrea, et al. "Bronchial Hyperresponsiveness, Airway Inflammation, and Reversibility in Patients With Chronic Obstructive Pulmonary Disease." International Journal of Chronic Obstructive Pulmonary Disease, vol. 10, 2015, pp. 1155-61.
Zanini A, Cherubino F, Zampogna E, et al. Bronchial hyperresponsiveness, airway inflammation, and reversibility in patients with chronic obstructive pulmonary disease. Int J Chron Obstruct Pulmon Dis. 2015;10:1155-61.
Zanini, A., Cherubino, F., Zampogna, E., Croce, S., Pignatti, P., & Spanevello, A. (2015). Bronchial hyperresponsiveness, airway inflammation, and reversibility in patients with chronic obstructive pulmonary disease. International Journal of Chronic Obstructive Pulmonary Disease, 10, pp. 1155-61. doi:10.2147/COPD.S80992.
Zanini A, et al. Bronchial Hyperresponsiveness, Airway Inflammation, and Reversibility in Patients With Chronic Obstructive Pulmonary Disease. Int J Chron Obstruct Pulmon Dis. 2015;10:1155-61. PubMed PMID: 26124655.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Bronchial hyperresponsiveness, airway inflammation, and reversibility in patients with chronic obstructive pulmonary disease. AU - Zanini,Andrea, AU - Cherubino,Francesca, AU - Zampogna,Elisabetta, AU - Croce,Stefania, AU - Pignatti,Patrizia, AU - Spanevello,Antonio, Y1 - 2015/06/17/ PY - 2015/7/1/entrez PY - 2015/7/1/pubmed PY - 2016/3/22/medline KW - COPD KW - exacerbations KW - hyperreactivity KW - methacholine KW - sputum eosinophilia SP - 1155 EP - 61 JF - International journal of chronic obstructive pulmonary disease JO - Int J Chron Obstruct Pulmon Dis VL - 10 N2 - BACKGROUND: Bronchial hyperresponsiveness (BHR), sputum eosinophilia, and bronchial reversibility are often thought to be a hallmark of asthma, yet it has been shown to occur in COPD as well. OBJECTIVES: To evaluate the relationship between BHR, lung function, and airway inflammation in COPD patients. METHODS: Thirty-one, steroid-free patients with stable, mild and moderate COPD were studied. The following tests were carried out: baseline lung function, reversibility, provocative dose of methacholine causing a 20% fall in forced expiratory volume in 1 second, a COPD symptom score, and sputum induction. RESULTS: Twenty-nine patients completed the procedures. About 41.4% had BHR, 31.0% had increased sputum eosinophils, and 37.9% had bronchial reversibility. Some of the patients had only one of these characteristics while others had two or the three of them. Patients with BHR had higher sputum eosinophils than patients without BHR (P=0.046) and those with sputum eosinophils ≥3% had more exacerbations in the previous year and a higher COPD symptom score than patients with sputum eosinophils <3% (P=0.019 and P=0.031, respectively). In patients with BHR, the cumulative dose of methacholine was negatively related to the symptom score and the number of exacerbations in the previous year. When patients with bronchial reversibility were considered, bronchodilation was positively related to sputum eosinophils. CONCLUSION: Our study showed that BHR, sputum eosinophilia, and bronchial reversibility were not clustered in one single phenotype of COPD but could be present alone or together. Of interest, BHR and airway eosinophilia were associated with clinical data in terms of exacerbations and symptoms. Further investigation is needed to clarify this topic. SN - 1178-2005 UR - https://www.unboundmedicine.com/medline/citation/26124655/Bronchial_hyperresponsiveness_airway_inflammation_and_reversibility_in_patients_with_chronic_obstructive_pulmonary_disease_ L2 - https://dx.doi.org/10.2147/COPD.S80992 DB - PRIME DP - Unbound Medicine ER -