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Human leukocyte antigen-B27 alleles in Xinjiang Uygur patients with ankylosing spondylitis.
Genet Mol Res. 2015 May 25; 14(2):5652-7.GM

Abstract

We investigated the distribution of human leukocyte antigen (HLA)-B27 subtypes in Uygur ankylosing spondylitis patients in Xinjiang. B27-positive patients with ankylosing spondylitis were subtyped by using polymerase chain reaction-sequence-based typing. The HLA-B27 subtype frequencies of Uygur patients were compared with those in Han patients in Xinjiang and the other areas of China. B*2705 was the predominant subtype in Uygur patients with a frequency of 58.95%, which was much higher than that in Han patients in Xinjiang (31.58%, P < 0.05) and the other areas of China (excluding the Shandong region, which was 63.89%). The frequency of B*2704 (27.37%) in Uygur patients was the lowest and significantly lower than that in Han patients (61.18%, P < 0.05) and in 8 other areas of China. B*2710 has not been previously reported in Uygur ankylosing spondylitis patients; B*2704 was the main (61.18%) subtype in Han patients in Xinjiang, followed by B*2705 (31.58%) and was similar to the characteristics of Han patients in the other areas of China. B*2724 in Han ankylosing spondylitis patients has not been previously reported. Additionally, the B*2702/B*2705 homozygote was identified in Uygur patients. B*2702/B*2704, B*2704/B*2705, and B*2705/B*2705 homozygotes were identified in 3 Han patients. The distribution of HLAB27 subtypes in Uygur ankylosing spondylitis patients in Xinjiang significantly differed from that in Han patients. Understanding the distribution of HLAB27 subtypes in ethnic minority populations of Xinjiang is important for anthropological genetic studies and for analyzing the impact of genetic background on ankylosing spondylitis susceptibility.

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Publisher Full Text (DOI)

Authors+Show Affiliations

Institute of Clinical Medicine, Urumqi General Hospital, Lanzhou Military Area Command, Urumqi, Xinjiang, China.

Institute of Clinical Medicine, Urumqi General Hospital, Lanzhou Military Area Command, Urumqi, Xinjiang, China.

Institute of Clinical Medicine, Urumqi General Hospital, Lanzhou Military Area Command, Urumqi, Xinjiang, China.

Institute of Clinical Medicine, Urumqi General Hospital, Lanzhou Military Area Command, Urumqi, Xinjiang, China.

Institute of Clinical Medicine, Urumqi General Hospital, Lanzhou Military Area Command, Urumqi, Xinjiang, China.

MeSH

AdolescentAdultAgedAllelesAsian PeopleChinaEthnicityFemaleGenetic Predisposition to DiseaseHLA-B27 AntigenHumansMaleMiddle AgedPolymorphism, Single NucleotideSpondylitis, Ankylosing

Pub Type(s)

Journal Article

Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

26125763

Citation

Zou, H-Y, et al. "Human Leukocyte antigen-B27 Alleles in Xinjiang Uygur Patients With Ankylosing Spondylitis." Genetics and Molecular Research : GMR, vol. 14, no. 2, 2015, pp. 5652-7.

Zou HY, Yu WZ, Wang Z, et al. Human leukocyte antigen-B27 alleles in Xinjiang Uygur patients with ankylosing spondylitis. Genet Mol Res. 2015;14(2):5652-7.

Zou, H. Y., Yu, W. Z., Wang, Z., He, J., & Jiao, M. (2015). Human leukocyte antigen-B27 alleles in Xinjiang Uygur patients with ankylosing spondylitis. Genetics and Molecular Research : GMR, 14(2), 5652-7. https://doi.org/10.4238/2015.May.25.17

Zou HY, et al. Human Leukocyte antigen-B27 Alleles in Xinjiang Uygur Patients With Ankylosing Spondylitis. Genet Mol Res. 2015 May 25;14(2):5652-7. PubMed PMID: 26125763.

* Article titles in AMA citation format should be in sentence-case

TY - JOUR T1 - Human leukocyte antigen-B27 alleles in Xinjiang Uygur patients with ankylosing spondylitis. AU - Zou,H-Y, AU - Yu,W-Z, AU - Wang,Z, AU - He,J, AU - Jiao,M, Y1 - 2015/05/25/ PY - 2015/7/1/entrez PY - 2015/7/1/pubmed PY - 2016/4/12/medline SP - 5652 EP - 7 JF - Genetics and molecular research : GMR JO - Genet Mol Res VL - 14 IS - 2 N2 - We investigated the distribution of human leukocyte antigen (HLA)-B27 subtypes in Uygur ankylosing spondylitis patients in Xinjiang. B27-positive patients with ankylosing spondylitis were subtyped by using polymerase chain reaction-sequence-based typing. The HLA-B27 subtype frequencies of Uygur patients were compared with those in Han patients in Xinjiang and the other areas of China. B*2705 was the predominant subtype in Uygur patients with a frequency of 58.95%, which was much higher than that in Han patients in Xinjiang (31.58%, P < 0.05) and the other areas of China (excluding the Shandong region, which was 63.89%). The frequency of B*2704 (27.37%) in Uygur patients was the lowest and significantly lower than that in Han patients (61.18%, P < 0.05) and in 8 other areas of China. B*2710 has not been previously reported in Uygur ankylosing spondylitis patients; B*2704 was the main (61.18%) subtype in Han patients in Xinjiang, followed by B*2705 (31.58%) and was similar to the characteristics of Han patients in the other areas of China. B*2724 in Han ankylosing spondylitis patients has not been previously reported. Additionally, the B*2702/B*2705 homozygote was identified in Uygur patients. B*2702/B*2704, B*2704/B*2705, and B*2705/B*2705 homozygotes were identified in 3 Han patients. The distribution of HLAB27 subtypes in Uygur ankylosing spondylitis patients in Xinjiang significantly differed from that in Han patients. Understanding the distribution of HLAB27 subtypes in ethnic minority populations of Xinjiang is important for anthropological genetic studies and for analyzing the impact of genetic background on ankylosing spondylitis susceptibility. SN - 1676-5680 UR - https://www.unboundmedicine.com/medline/citation/26125763/Human_leukocyte_antigen_B27_alleles_in_Xinjiang_Uygur_patients_with_ankylosing_spondylitis_ DB - PRIME DP - Unbound Medicine ER -