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The balance of the evidence on acid-base homeostasis and progression of chronic kidney disease.
Kidney Int. 2015 Jul; 88(1):9-11.KI

Abstract

Normalization of acid-base homeostasis in chronic kidney disease (CKD) holds promise for mitigating disease progression, but whether efforts should focus on patients with low serum bicarbonate or high dietary acid load is unknown. Vallet et al. report that low urinary ammonia excretion independently associates with increased progression in moderate CKD. Whether this finding implicates differences in endogenous acid production or the ability to excrete an acid load in the pathogenesis of progression requires further study.

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Authors+Show Affiliations

Scialla JJ
1] Division of Nephrology, Duke University School of Medicine, Durham, North Carolina, USA [2] Duke Clinical Research Institute, Duke University School of Medicine, Durham, North Carolina, USA.

MeSH

AmmoniaCarbon DioxideFemaleHumansMaleRenal Insufficiency, Chronic

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Comment

Language

eng

PubMed ID

26126088

Citation

Scialla, Julia J.. "The Balance of the Evidence On Acid-base Homeostasis and Progression of Chronic Kidney Disease." Kidney International, vol. 88, no. 1, 2015, pp. 9-11.
Scialla JJ. The balance of the evidence on acid-base homeostasis and progression of chronic kidney disease. Kidney Int. 2015;88(1):9-11.
Scialla, J. J. (2015). The balance of the evidence on acid-base homeostasis and progression of chronic kidney disease. Kidney International, 88(1), 9-11. https://doi.org/10.1038/ki.2015.87
Scialla JJ. The Balance of the Evidence On Acid-base Homeostasis and Progression of Chronic Kidney Disease. Kidney Int. 2015;88(1):9-11. PubMed PMID: 26126088.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The balance of the evidence on acid-base homeostasis and progression of chronic kidney disease. A1 - Scialla,Julia J, PY - 2015/7/1/entrez PY - 2015/7/1/pubmed PY - 2016/5/24/medline SP - 9 EP - 11 JF - Kidney international JO - Kidney Int VL - 88 IS - 1 N2 - Normalization of acid-base homeostasis in chronic kidney disease (CKD) holds promise for mitigating disease progression, but whether efforts should focus on patients with low serum bicarbonate or high dietary acid load is unknown. Vallet et al. report that low urinary ammonia excretion independently associates with increased progression in moderate CKD. Whether this finding implicates differences in endogenous acid production or the ability to excrete an acid load in the pathogenesis of progression requires further study. SN - 1523-1755 UR - https://www.unboundmedicine.com/medline/citation/26126088/full_citation DB - PRIME DP - Unbound Medicine ER -