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The balance of the evidence on acid-base homeostasis and progression of chronic kidney disease.

Abstract

Normalization of acid-base homeostasis in chronic kidney disease (CKD) holds promise for mitigating disease progression, but whether efforts should focus on patients with low serum bicarbonate or high dietary acid load is unknown. Vallet et al. report that low urinary ammonia excretion independently associates with increased progression in moderate CKD. Whether this finding implicates differences in endogenous acid production or the ability to excrete an acid load in the pathogenesis of progression requires further study.

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  • Authors+Show Affiliations

    1] Division of Nephrology, Duke University School of Medicine, Durham, North Carolina, USA [2] Duke Clinical Research Institute, Duke University School of Medicine, Durham, North Carolina, USA.

    Source

    Kidney international 88:1 2015 Jul pg 9-11

    MeSH

    Ammonia
    Carbon Dioxide
    Female
    Humans
    Male
    Renal Insufficiency, Chronic

    Pub Type(s)

    Comment
    Journal Article
    Research Support, N.I.H., Extramural

    Language

    eng

    PubMed ID

    26126088

    Citation

    TY - JOUR T1 - The balance of the evidence on acid-base homeostasis and progression of chronic kidney disease. A1 - Scialla,Julia J, PY - 2015/7/1/entrez PY - 2015/7/1/pubmed PY - 2016/5/24/medline SP - 9 EP - 11 JF - Kidney international JO - Kidney Int. VL - 88 IS - 1 N2 - Normalization of acid-base homeostasis in chronic kidney disease (CKD) holds promise for mitigating disease progression, but whether efforts should focus on patients with low serum bicarbonate or high dietary acid load is unknown. Vallet et al. report that low urinary ammonia excretion independently associates with increased progression in moderate CKD. Whether this finding implicates differences in endogenous acid production or the ability to excrete an acid load in the pathogenesis of progression requires further study. SN - 1523-1755 UR - https://www.unboundmedicine.com/medline/citation/26126088/full_citation L2 - http://linkinghub.elsevier.com/retrieve/pii/S2157-1716(15)32152-3 ER -