Tags

Type your tag names separated by a space and hit enter

HbA1c, Fructosamine, and Glycated Albumin in the Detection of Dysglycaemic Conditions.
Curr Diabetes Rev. 2016; 12(1):14-9.CD

Abstract

Glycated haemoglobin (HbA1c) is currently the gold standard for glucose monitoring in patients with diabetes, and has been increasingly adopted as a criteria for diabetes diagnosis. However, conditions that determine alterations in haemoglobin metabolism can interfere with the reliability of HbA1c measurements. Glycated albumin and fructosamine (total glycated serum proteins) are alternative markers of glycaemia, which have been recognised to provide additional information to HbA1c or to provide a reliable measure when HbA1c is observed not to be dependable. Additionally, while HbA1c monitors the exposure to circulating glycaemia in the previous 3 months, glycated albumin and fructosamine represent exposure for a shorter period, which may be beneficial to monitor rapid metabolic alterations or changes in diabetes treatment. The present review further discusses the relative value of HbA1c, glycated albumin, and fructosamine, in prediabetes and diabetes diagnosis, evaluation of glucose variability, and complications risk prediction. Also, a novel molecular role for albumin is presented by which glycated albumin contributes to glucose intolerance development and thus to progression to diabetes, besides the role of glycated albumin as a pro-atherogenic factor.

Authors+Show Affiliations

Ribeiro RT
No affiliation info available
Macedo MP
No affiliation info available
Raposo JF
APDP - Diabetes Portugal, Rua Rodrigo da Fonseca, 1, 1250-189 Lisboa, Portugal. filipe.raposo@apdp.pt.

MeSH

BiomarkersBlood GlucoseDiabetes MellitusFructosamineGlucose IntoleranceGlycated HemoglobinGlycation End Products, AdvancedHumansReproducibility of ResultsSerum AlbuminGlycated Serum Albumin

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

26126638

Clinical Trial Links

Obesity in Pediatric Sickle Cell Disease: A New Phenomenon

Citation

Ribeiro, Rogério Tavares, et al. "HbA1c, Fructosamine, and Glycated Albumin in the Detection of Dysglycaemic Conditions." Current Diabetes Reviews, vol. 12, no. 1, 2016, pp. 14-9.
Ribeiro RT, Macedo MP, Raposo JF. HbA1c, Fructosamine, and Glycated Albumin in the Detection of Dysglycaemic Conditions. Curr Diabetes Rev. 2016;12(1):14-9.
Ribeiro, R. T., Macedo, M. P., & Raposo, J. F. (2016). HbA1c, Fructosamine, and Glycated Albumin in the Detection of Dysglycaemic Conditions. Current Diabetes Reviews, 12(1), 14-9.
Ribeiro RT, Macedo MP, Raposo JF. HbA1c, Fructosamine, and Glycated Albumin in the Detection of Dysglycaemic Conditions. Curr Diabetes Rev. 2016;12(1):14-9. PubMed PMID: 26126638.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - HbA1c, Fructosamine, and Glycated Albumin in the Detection of Dysglycaemic Conditions. AU - Ribeiro,Rogério Tavares, AU - Macedo,Maria Paula, AU - Raposo,João Filipe, PY - 2015/03/18/received PY - 2015/05/27/revised PY - 2015/06/11/accepted PY - 2015/7/2/entrez PY - 2015/7/2/pubmed PY - 2016/6/14/medline SP - 14 EP - 9 JF - Current diabetes reviews JO - Curr Diabetes Rev VL - 12 IS - 1 N2 - Glycated haemoglobin (HbA1c) is currently the gold standard for glucose monitoring in patients with diabetes, and has been increasingly adopted as a criteria for diabetes diagnosis. However, conditions that determine alterations in haemoglobin metabolism can interfere with the reliability of HbA1c measurements. Glycated albumin and fructosamine (total glycated serum proteins) are alternative markers of glycaemia, which have been recognised to provide additional information to HbA1c or to provide a reliable measure when HbA1c is observed not to be dependable. Additionally, while HbA1c monitors the exposure to circulating glycaemia in the previous 3 months, glycated albumin and fructosamine represent exposure for a shorter period, which may be beneficial to monitor rapid metabolic alterations or changes in diabetes treatment. The present review further discusses the relative value of HbA1c, glycated albumin, and fructosamine, in prediabetes and diabetes diagnosis, evaluation of glucose variability, and complications risk prediction. Also, a novel molecular role for albumin is presented by which glycated albumin contributes to glucose intolerance development and thus to progression to diabetes, besides the role of glycated albumin as a pro-atherogenic factor. SN - 1875-6417 UR - https://www.unboundmedicine.com/medline/citation/26126638/HbA1c_Fructosamine_and_Glycated_Albumin_in_the_Detection_of_Dysglycaemic_Conditions_ DB - PRIME DP - Unbound Medicine ER -