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Dietary vitamin E intake could reduce the risk of lung cancer: evidence from a meta-analysis.

Abstract

BACKGROUND

Quantification of the association between the intake of vitamin E and risk of lung cancer is still conflicting. Thus, we conducted a meta-analysis to summarize the evidence from epidemiological studies of vitamin E intake with the risk of lung cancer.

METHODS

Pertinent studies were identified by a search in PubMed and Web of Knowledge up to October 2014. Random-effect model was used to combine study-specific results. Publication bias was estimated using Egger's regression asymmetry test.

RESULTS

Ten articles reporting 11 studies (10 prospective studies and 1 case-control studies) involving 4434 lung cancer cases were used in this meta-analysis. The combined relative risk (RR) of lung cancer associated with vitamin E intake was 0.858 (95% CI=0.742-0.991) overall, significant protective associations were also found in America population (RR=0.862, 95% CI=0.715-0.996) and prospective studies (RR=0.913, 95% CI=0.827-0.996). No publication bias was found.

CONCLUSIONS

Our analysis indicated that vitamin E intake might decrease the risk of lung cancer, especially in America.

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  • Authors+Show Affiliations

    ,

    Department of Thoracic Surgery, East Hospital, Tongji University School of Medicine 150 Jimo Road, Shanghai 200120, China.

    ,

    Department of Thoracic Surgery, East Hospital, Tongji University School of Medicine 150 Jimo Road, Shanghai 200120, China.

    ,

    Department of Thoracic Surgery, East Hospital, Tongji University School of Medicine 150 Jimo Road, Shanghai 200120, China.

    ,

    Department of Thoracic Surgery, East Hospital, Tongji University School of Medicine 150 Jimo Road, Shanghai 200120, China.

    Department of Thoracic Surgery, East Hospital, Tongji University School of Medicine 150 Jimo Road, Shanghai 200120, China.

    Source

    Pub Type(s)

    Journal Article

    Language

    eng

    PubMed ID

    26131295

    Citation

    Chen, Guohan, et al. "Dietary Vitamin E Intake Could Reduce the Risk of Lung Cancer: Evidence From a Meta-analysis." International Journal of Clinical and Experimental Medicine, vol. 8, no. 4, 2015, pp. 6631-7.
    Chen G, Wang J, Hong X, et al. Dietary vitamin E intake could reduce the risk of lung cancer: evidence from a meta-analysis. Int J Clin Exp Med. 2015;8(4):6631-7.
    Chen, G., Wang, J., Hong, X., Chai, Z., & Li, Q. (2015). Dietary vitamin E intake could reduce the risk of lung cancer: evidence from a meta-analysis. International Journal of Clinical and Experimental Medicine, 8(4), pp. 6631-7.
    Chen G, et al. Dietary Vitamin E Intake Could Reduce the Risk of Lung Cancer: Evidence From a Meta-analysis. Int J Clin Exp Med. 2015;8(4):6631-7. PubMed PMID: 26131295.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Dietary vitamin E intake could reduce the risk of lung cancer: evidence from a meta-analysis. AU - Chen,Guohan, AU - Wang,Jinyi, AU - Hong,Xuan, AU - Chai,Zhengjun, AU - Li,Qinchuan, Y1 - 2015/04/15/ PY - 2015/01/04/received PY - 2015/03/01/accepted PY - 2015/7/2/entrez PY - 2015/7/2/pubmed PY - 2015/7/2/medline KW - Vitamin E KW - lung cancer KW - meta-analysis SP - 6631 EP - 7 JF - International journal of clinical and experimental medicine JO - Int J Clin Exp Med VL - 8 IS - 4 N2 - BACKGROUND: Quantification of the association between the intake of vitamin E and risk of lung cancer is still conflicting. Thus, we conducted a meta-analysis to summarize the evidence from epidemiological studies of vitamin E intake with the risk of lung cancer. METHODS: Pertinent studies were identified by a search in PubMed and Web of Knowledge up to October 2014. Random-effect model was used to combine study-specific results. Publication bias was estimated using Egger's regression asymmetry test. RESULTS: Ten articles reporting 11 studies (10 prospective studies and 1 case-control studies) involving 4434 lung cancer cases were used in this meta-analysis. The combined relative risk (RR) of lung cancer associated with vitamin E intake was 0.858 (95% CI=0.742-0.991) overall, significant protective associations were also found in America population (RR=0.862, 95% CI=0.715-0.996) and prospective studies (RR=0.913, 95% CI=0.827-0.996). No publication bias was found. CONCLUSIONS: Our analysis indicated that vitamin E intake might decrease the risk of lung cancer, especially in America. SN - 1940-5901 UR - https://www.unboundmedicine.com/medline/citation/26131295/Dietary_vitamin_E_intake_could_reduce_the_risk_of_lung_cancer:_evidence_from_a_meta_analysis_ L2 - https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/26131295/ DB - PRIME DP - Unbound Medicine ER -